7fjc - Revision history

OCA at 17:16, 29 November 2023

OCA — Wed, 29 Nov 2023 17:16:51 GMT

←Older revision		Revision as of 17:16, 29 November 2023
Line 1:		Line 1:

-	====	+	==Crystal structure of SARS-CoV-2 Beta RBD complexed with P36-5D2 Fab==
-	<StructureSection load='7fjc' size='340' side='right'caption='[[7fjc]]' scene=''>	+	<StructureSection load='7fjc' size='340' side='right'caption='[[7fjc]], [[Resolution\|resolution]] 2.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7fjc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FJC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fjc OCA], [https://pdbe.org/7fjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fjc RCSB], [https://www.ebi.ac.uk/pdbsum/7fjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fjc ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.96Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fjc OCA], [https://pdbe.org/7fjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fjc RCSB], [https://www.ebi.ac.uk/pdbsum/7fjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fjc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Lan J]]
		+	[[Category: Shan SS]]
		+	[[Category: Wang XQ]]
		+	[[Category: Zhang LQ]]

OCA at 04:58, 10 August 2022

OCA — Wed, 10 Aug 2022 04:58:08 GMT

←Older revision		Revision as of 04:58, 10 August 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7fjc ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7fjc' size='340' side='right'caption='[[7fjc]]' scene=''>
-	~~Authors~~: ~~Zhang, L~~.Q.~~, Wang, X~~.Q.~~, Shan, S~~.S.~~, Lan, J~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of SARS-CoV-2 Beta RBD complexed with P36-5D2 Fab~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fjc OCA], [https://pdbe.org/7fjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fjc RCSB], [https://www.ebi.ac.uk/pdbsum/7fjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fjc ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Lan, J~~]]	+	__TOC__
-	[~~[Category~~: ~~Shan~~, S.S]]	+	</StructureSection>
-	[[Category: ~~Wang, X.Q~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Zhang, L.Q~~]]	+	[[Category: Z-disk]]

OCA at 11:45, 29 December 2021

OCA — Wed, 29 Dec 2021 11:45:09 GMT

←Older revision		Revision as of 11:45, 29 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7fjc is ON HOLD	+	The entry 7fjc is ON HOLD until Paper Publication

	Authors: Zhang, L.Q., Wang, X.Q., Shan, S.S., Lan, J.		Authors: Zhang, L.Q., Wang, X.Q., Shan, S.S., Lan, J.

OCA: Protected "7fjc" [edit=sysop:move=sysop]

OCA — Wed, 11 Aug 2021 04:59:23 GMT

Protected "7fjc" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:59, 11 August 2021

OCA: New page: '''Unreleased structure''' The entry 7fjc is ON HOLD Authors: Zhang, L.Q., Wang, X.Q., Shan, S.S., Lan, J. Description: Crystal structure of SARS-CoV-2 Beta RBD complexed with P36-5D2 ...

OCA — Wed, 11 Aug 2021 04:59:23 GMT

New page: '''Unreleased structure''' The entry 7fjc is ON HOLD Authors: Zhang, L.Q., Wang, X.Q., Shan, S.S., Lan, J. Description: Crystal structure of SARS-CoV-2 Beta RBD complexed with P36-5D2 ...

New page

'''Unreleased structure'''

The entry 7fjc is ON HOLD

Authors: Zhang, L.Q., Wang, X.Q., Shan, S.S., Lan, J.

Description: Crystal structure of SARS-CoV-2 Beta RBD complexed with P36-5D2 Fab
[[Category: Unreleased Structures]]
[[Category: Lan, J]]
[[Category: Shan, S.S]]
[[Category: Wang, X.Q]]
[[Category: Zhang, L.Q]]