OCA at 08:51, 21 February 2024

OCA — Wed, 21 Feb 2024 08:51:56 GMT

←Older revision		Revision as of 08:51, 21 February 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 7ful is ~~ON HOLD~~	+	==Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-4-methylphenyl)-3-[3-(methanesulfonamido)propyl]benzimidazole-4-carboxylic acid==
-		+	<StructureSection load='7ful' size='340' side='right'caption='[[7ful]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7ful]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FUL FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.296Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YUO:(5M)-5-(2-chloro-4-methylphenyl)-1-{3-[(methanesulfonyl)amino]propyl}-1H-benzimidazole-7-carboxylic+acid'>YUO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ful OCA], [https://pdbe.org/7ful PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ful RCSB], [https://www.ebi.ac.uk/pdbsum/7ful PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ful ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Benz J]]
		+	[[Category: Galley G]]
		+	[[Category: Groebke-Zbinden K]]
		+	[[Category: Leibrock L]]
		+	[[Category: Rudolph MG]]

OCA: Protected "7ful" [edit=sysop:move=sysop]

OCA — Wed, 15 Feb 2023 08:20:27 GMT

Protected "7ful" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:20, 15 February 2023

OCA: New page: '''Unreleased structure''' The entry 7ful is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Feb 2023 08:20:26 GMT

New page: '''Unreleased structure''' The entry 7ful is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ful is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7ful - Revision history

OCA at 08:51, 21 February 2024

OCA: Protected "7ful" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ful is ON HOLD Authors: Description: Category: Unreleased Structures