7g8k - Revision history

OCA at 10:34, 22 May 2024

OCA — Wed, 22 May 2024 10:34:48 GMT

←Older revision		Revision as of 10:34, 22 May 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>		[https://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
		+
		+	==See Also==
		+	*[[Rho guanine nucleotide exchange factor 3D structures\|Rho guanine nucleotide exchange factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:06, 12 July 2023

OCA — Wed, 12 Jul 2023 07:06:58 GMT

←Older revision		Revision as of 07:06, 12 July 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7g8k is ~~ON HOLD~~	+	==ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1217131798==
-		+	<StructureSection load='7g8k' size='340' side='right'caption='[[7g8k]], [[Resolution\|resolution]] 1.49Å' scene=''>
-	~~Authors~~: ~~Bradshaw~~, W.J., ~~Katis, V~~.L., ~~Bountra~~, C., ~~von Delft, F~~., ~~Brennan, P~~.E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7g8k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7G8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7G8K FirstGlance]. <br>
-	~~Description~~: ~~ARHGEF2 PanDDA analysis group deposition~~ --ARHGEF2 and ~~RhoA~~ in ~~complex with Z1217131798~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.491Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=YZK:(3M)-3-(2-methyl-1H-imidazol-1-yl)pyridine'>YZK</scene></td></tr>
-	[[Category: ~~Katis, V.L~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7g8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7g8k OCA], [https://pdbe.org/7g8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7g8k RCSB], [https://www.ebi.ac.uk/pdbsum/7g8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7g8k ProSAT]</span></td></tr>
-	[[Category: ~~Von Delft, F~~]]	+	</table>
-	[[Category: ~~Bountra, C~~]]	+	== Function ==
-	[[Category: Brennan~~, P.E~~]]	+	[https://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
-	[[Category: ~~Bradshaw, W.J~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Bountra C]]
		+	[[Category: Bradshaw WJ]]
		+	[[Category: Brennan PE]]
		+	[[Category: Katis VL]]
		+	[[Category: Von Delft F]]

OCA: Protected "7g8k" [edit=sysop:move=sysop]

OCA — Wed, 28 Jun 2023 19:32:18 GMT

Protected "7g8k" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:32, 28 June 2023

OCA: New page: '''Unreleased structure''' The entry 7g8k is ON HOLD Authors: Bradshaw, W.J., Katis, V.L., Bountra, C., von Delft, F., Brennan, P.E. Description: ARHGEF2 PanDDA analysis group depositi...

OCA — Wed, 28 Jun 2023 19:32:17 GMT

New page: '''Unreleased structure''' The entry 7g8k is ON HOLD Authors: Bradshaw, W.J., Katis, V.L., Bountra, C., von Delft, F., Brennan, P.E. Description: ARHGEF2 PanDDA analysis group depositi...

New page

'''Unreleased structure'''

The entry 7g8k is ON HOLD

Authors: Bradshaw, W.J., Katis, V.L., Bountra, C., von Delft, F., Brennan, P.E.

Description: ARHGEF2 PanDDA analysis group deposition --ARHGEF2 and RhoA in complex with Z1217131798
[[Category: Unreleased Structures]]
[[Category: Katis, V.L]]
[[Category: Von Delft, F]]
[[Category: Bountra, C]]
[[Category: Brennan, P.E]]
[[Category: Bradshaw, W.J]]