OCA at 12:32, 26 July 2023

OCA — Wed, 26 Jul 2023 12:32:26 GMT

←Older revision		Revision as of 12:32, 26 July 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7g9u ~~is ON HOLD~~	+	==PanDDA analysis group deposition -- Crystal Structure of Zika virus NS3 Helicase in complex with Z55222357==
-		+	<StructureSection load='7g9u' size='340' side='right'caption='[[7g9u]], [[Resolution\|resolution]] 1.69Å' scene=''>
-	~~Authors~~: ~~Godoy, A~~.S.~~, Noske, G~~.D., ~~Fairhead, M~~., ~~Lithgo~~, ~~R.M.~~, ~~Koekemoer~~, L., ~~Aschenbrenner~~, J.C., ~~Balcomb, B~~.H., ~~Marples~~, P.G., ~~Ni, X~~., ~~Tomlinson, C~~.W.E., ~~Wild, C~~., ~~Mesquita, N~~.C.M.R., ~~Oliva, G~~.~~, Fearon, D~~., ~~Walsh, M~~.A., ~~von Delft, F~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7g9u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7G9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7G9U FirstGlance]. <br>
-	~~Description: THE CRYSTAL STRUCTURE OF ZIKA VIRUS NS3 HELICASE DOMAIN~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.689Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZV2:2-(2-azanyl-1,3-thiazol-3-yl)-~{N}-(4-fluorophenyl)ethanamide'>ZV2</scene></td></tr>
-	[[Category: ~~Noske, G.D~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7g9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7g9u OCA], [https://pdbe.org/7g9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7g9u RCSB], [https://www.ebi.ac.uk/pdbsum/7g9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7g9u ProSAT]</span></td></tr>
-	[[Category: Balcomb~~, B.H~~]]	+	</table>
-	[[Category: ~~Mesquita, N.C.~~M.R]]	+	== Function ==
-	[[Category: ~~Lithgo, R.M~~]]	+	[https://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763] prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763] Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763] Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763] Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732] Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763] Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]
-	[[Category: Godoy~~, A.S~~]]	+	__TOC__
-	[[Category: ~~Fearon, D~~]]	+	</StructureSection>
-	[[Category: ~~Walsh, M.A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Oliva, G~~]]	+	[[Category: Zika virus]]
-	[[Category: ~~Fairhead, M~~]]	+	[[Category: Aschenbrenner JC]]
-	[[Category: ~~Von Delft, F~~]]	+	[[Category: Balcomb BH]]
-	[[Category: ~~Marples, P.G~~]]	+	[[Category: Fairhead M]]
-	[[Category: ~~Koekemoer, L~~]]	+	[[Category: Fearon D]]
-	[[Category: ~~Wild, C~~]]	+	[[Category: Godoy AS]]
-	[[Category: ~~Ni, X~~]]	+	[[Category: Koekemoer L]]
-	[[Category: ~~Aschenbrenner, J.~~C]]	+	[[Category: Lithgo RM]]
-	[[Category: ~~Tomlinson, C.W.E~~]]	+	[[Category: Marples PG]]
		+	[[Category: Mesquita NCMR]]
		+	[[Category: Ni X]]
		+	[[Category: Noske GD]]
		+	[[Category: Oliva G]]
		+	[[Category: Tomlinson CWE]]
		+	[[Category: Walsh MA]]
		+	[[Category: Wild C]]
		+	[[Category: Von Delft F]]

OCA: Protected "7g9u" [edit=sysop:move=sysop]

OCA — Wed, 12 Jul 2023 03:40:41 GMT

Protected "7g9u" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:40, 12 July 2023

OCA: New page: '''Unreleased structure''' The entry 7g9u is ON HOLD Authors: Godoy, A.S., Noske, G.D., Fairhead, M., Lithgo, R.M., Koekemoer, L., Aschenbrenner, J.C., Balcomb, B.H., Marples, P.G., Ni,...

OCA — Wed, 12 Jul 2023 03:40:37 GMT

New page: '''Unreleased structure''' The entry 7g9u is ON HOLD Authors: Godoy, A.S., Noske, G.D., Fairhead, M., Lithgo, R.M., Koekemoer, L., Aschenbrenner, J.C., Balcomb, B.H., Marples, P.G., Ni,...

New page

'''Unreleased structure'''

The entry 7g9u is ON HOLD

Authors: Godoy, A.S., Noske, G.D., Fairhead, M., Lithgo, R.M., Koekemoer, L., Aschenbrenner, J.C., Balcomb, B.H., Marples, P.G., Ni, X., Tomlinson, C.W.E., Wild, C., Mesquita, N.C.M.R., Oliva, G., Fearon, D., Walsh, M.A., von Delft, F.

Description: THE CRYSTAL STRUCTURE OF ZIKA VIRUS NS3 HELICASE DOMAIN
[[Category: Unreleased Structures]]
[[Category: Noske, G.D]]
[[Category: Balcomb, B.H]]
[[Category: Mesquita, N.C.M.R]]
[[Category: Lithgo, R.M]]
[[Category: Godoy, A.S]]
[[Category: Fearon, D]]
[[Category: Walsh, M.A]]
[[Category: Oliva, G]]
[[Category: Fairhead, M]]
[[Category: Von Delft, F]]
[[Category: Marples, P.G]]
[[Category: Koekemoer, L]]
[[Category: Wild, C]]
[[Category: Ni, X]]
[[Category: Aschenbrenner, J.C]]
[[Category: Tomlinson, C.W.E]]

7g9u - Revision history

OCA at 12:32, 26 July 2023

OCA: Protected "7g9u" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7g9u is ON HOLD Authors: Godoy, A.S., Noske, G.D., Fairhead, M., Lithgo, R.M., Koekemoer, L., Aschenbrenner, J.C., Balcomb, B.H., Marples, P.G., Ni,...