OCA at 08:26, 9 May 2024

OCA — Thu, 09 May 2024 08:26:34 GMT

←Older revision		Revision as of 08:26, 9 May 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7h29 ~~is ON HOLD~~	+	==PanDDA analysis group deposition -- Crystal Structure of ZIKV NS2B-NS3 protease in complex with Z1269184613==
-		+	<StructureSection load='7h29' size='340' side='right'caption='[[7h29]], [[Resolution\|resolution]] 1.77Å' scene=''>
-	~~Authors~~: ~~Ni, X~~.~~, Godoy, A~~.S.~~, Marples, P~~.G., ~~Fairhead, M~~., ~~Balcomb~~, B.H., ~~Tomlinson, C~~.W.E., ~~Koekemoer, L~~., ~~Aschenbrenner, J~~.C., ~~Lithgo, R~~.M.~~, Thompson, W~~., ~~Wild,~~ C.~~, Williams,~~ E.P., ~~Winokan,~~ M.~~, Chandran, A~~.V.~~, Fearon, D~~., ~~Walsh,~~ M.A., ~~von Delft, F~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7h29]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7H29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7H29 FirstGlance]. <br>
-	~~Description~~: ~~PanDDA analysis group deposition~~ --~~Crystal Structure~~ of ~~ZIKV NS2B~~-~~NS3 protease in complex with Z1269184613~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.77Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z2F:1,3-benzothiazole-6-sulfonamide'>Z2F</scene></td></tr>
-	[[Category: ~~Balcomb, B.H~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7h29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7h29 OCA], [https://pdbe.org/7h29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7h29 RCSB], [https://www.ebi.ac.uk/pdbsum/7h29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7h29 ProSAT]</span></td></tr>
-	[[Category: ~~Chandran, A.V~~]]	+	</table>
-	[[Category: ~~Williams, E.P~~]]	+	== Function ==
-	[[Category: ~~Lithgo, R.M~~]]	+	[https://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763] prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763] Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763] Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763] Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732] Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763] Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]
-	[[Category: ~~Godoy, A.S~~]]	+	__TOC__
-	[[Category: Fearon, D]]	+	</StructureSection>
-	[[Category: ~~Walsh, M.A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Thompson, W~~]]	+	[[Category: Zika virus]]
-	[[Category: ~~Fairhead, M~~]]	+	[[Category: Aschenbrenner JC]]
-	[[Category: ~~Von Delft, F~~]]	+	[[Category: Balcomb BH]]
-	[[Category: ~~Marples, P.G~~]]	+	[[Category: Chandran AV]]
-	[[Category: ~~Koekemoer, L~~]]	+	[[Category: Fairhead M]]
-	[[Category: ~~Wild, C~~]]	+	[[Category: Fearon D]]
-	[[Category: ~~Ni, X~~]]	+	[[Category: Godoy AS]]
-	[[Category: ~~Aschenbrenner, J.~~C]]	+	[[Category: Koekemoer L]]
-	[[Category: Winokan, M]]	+	[[Category: Lithgo RM]]
-	[[Category: ~~Tomlinson, C.W.E~~]]	+	[[Category: Marples PG]]
		+	[[Category: Ni X]]
		+	[[Category: Thompson W]]
		+	[[Category: Tomlinson CWE]]
		+	[[Category: Walsh MA]]
		+	[[Category: Wild C]]
		+	[[Category: Williams EP]]
		+	[[Category: Winokan M]]
		+	[[Category: Von Delft F]]

OCA: Protected "7h29" [edit=sysop:move=sysop]

OCA — Wed, 10 Apr 2024 06:17:51 GMT

Protected "7h29" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:17, 10 April 2024

OCA: New page: '''Unreleased structure''' The entry 7h29 is ON HOLD Authors: Ni, X., Godoy, A.S., Marples, P.G., Fairhead, M., Balcomb, B.H., Tomlinson, C.W.E., Koekemoer, L., Aschenbrenner, J.C., Lit...

OCA — Wed, 10 Apr 2024 06:17:49 GMT

New page: '''Unreleased structure''' The entry 7h29 is ON HOLD Authors: Ni, X., Godoy, A.S., Marples, P.G., Fairhead, M., Balcomb, B.H., Tomlinson, C.W.E., Koekemoer, L., Aschenbrenner, J.C., Lit...

New page

'''Unreleased structure'''

The entry 7h29 is ON HOLD

Authors: Ni, X., Godoy, A.S., Marples, P.G., Fairhead, M., Balcomb, B.H., Tomlinson, C.W.E., Koekemoer, L., Aschenbrenner, J.C., Lithgo, R.M., Thompson, W., Wild, C., Williams, E.P., Winokan, M., Chandran, A.V., Fearon, D., Walsh, M.A., von Delft, F.

Description: PanDDA analysis group deposition --Crystal Structure of ZIKV NS2B-NS3 protease in complex with Z1269184613
[[Category: Unreleased Structures]]
[[Category: Balcomb, B.H]]
[[Category: Chandran, A.V]]
[[Category: Williams, E.P]]
[[Category: Lithgo, R.M]]
[[Category: Godoy, A.S]]
[[Category: Fearon, D]]
[[Category: Walsh, M.A]]
[[Category: Thompson, W]]
[[Category: Fairhead, M]]
[[Category: Von Delft, F]]
[[Category: Marples, P.G]]
[[Category: Koekemoer, L]]
[[Category: Wild, C]]
[[Category: Ni, X]]
[[Category: Aschenbrenner, J.C]]
[[Category: Winokan, M]]
[[Category: Tomlinson, C.W.E]]

7h29 - Revision history

OCA at 08:26, 9 May 2024

OCA: Protected "7h29" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7h29 is ON HOLD Authors: Ni, X., Godoy, A.S., Marples, P.G., Fairhead, M., Balcomb, B.H., Tomlinson, C.W.E., Koekemoer, L., Aschenbrenner, J.C., Lit...