7jkz - Revision history

OCA at 15:06, 18 October 2023

OCA — Wed, 18 Oct 2023 15:06:03 GMT

←Older revision		Revision as of 15:06, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='7jkz' size='340' side='right'caption='[[7jkz]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='7jkz' size='340' side='right'caption='[[7jkz]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7jkz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jkz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JKZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YF6:N-(1-[1,1-di(pyridin-2-yl)ethyl]-6-{1-methyl-6-oxo-5-[(piperidin-4-yl)amino]-1,6-dihydropyridin-3-yl}-1H-indol-4-yl)ethanesulfonamide'>YF6</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.49Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YF6:N-(1-[1,1-di(pyridin-2-yl)ethyl]-6-{1-methyl-6-oxo-5-[(piperidin-4-yl)amino]-1,6-dihydropyridin-3-yl}-1H-indol-4-yl)ethanesulfonamide'>YF6</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jkz OCA], [https://pdbe.org/7jkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jkz RCSB], [https://www.ebi.ac.uk/pdbsum/7jkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jkz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jkz OCA], [https://pdbe.org/7jkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jkz RCSB], [https://www.ebi.ac.uk/pdbsum/7jkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jkz ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7jkz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7jkz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dubrovyskyii, O]]	+	[[Category: Dubrovyskyii O]]
-	[[Category: Huang, F]]	+	[[Category: Huang F]]
-	[[Category: Li, Y]]	+	[[Category: Li Y]]
-	[[Category: Ratia~~, K M~~]]	+	[[Category: Ratia KM]]
-	[[Category: Shen, Z]]	+	[[Category: Shen Z]]
-	[[Category: Thatcher~~, G R~~]]	+	[[Category: Thatcher GR]]
-	[[Category: Xiong, R]]	+	[[Category: Xiong R]]
-	[[Category: Zhao, J]]	+	[[Category: Zhao J]]
-	~~[[Category: Selective brd4-bd1 inhibitor]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:16, 16 March 2022

OCA — Wed, 16 Mar 2022 07:16:22 GMT

←Older revision		Revision as of 07:16, 16 March 2022
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	==Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with YF3-126==		==Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with YF3-126==
-	<StructureSection load='7jkz' size='340' side='right'caption='[[7jkz]]' scene=''>	+	<StructureSection load='7jkz' size='340' side='right'caption='[[7jkz]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jkz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JKZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jkz OCA], [https://pdbe.org/7jkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jkz RCSB], [https://www.ebi.ac.uk/pdbsum/7jkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jkz ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YF6:N-(1-[1,1-di(pyridin-2-yl)ethyl]-6-{1-methyl-6-oxo-5-[(piperidin-4-yl)amino]-1,6-dihydropyridin-3-yl}-1H-indol-4-yl)ethanesulfonamide'>YF6</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jkz OCA], [https://pdbe.org/7jkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jkz RCSB], [https://www.ebi.ac.uk/pdbsum/7jkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jkz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Acquired resistance to fulvestrant and palbociclib is a new challenge to treatment of estrogen receptor positive (ER+) breast cancer. ER is expressed in most resistance settings; thus, bromodomain and extra-terminal protein inhibitors (BETi) that target BET-amplified ER-mediated transcription have therapeutic potential. Novel pyrrolopyridone BETi leveraged novel interactions with L92/L94 confirmed by a cocrystal structure of 27 with BRD4. Optimization of BETi using growth inhibition in fulvestrant-resistant (MCF-7:CFR) cells was confirmed in endocrine-resistant, palbociclib-resistant, and ESR1 mutant cell lines. 27 was more potent in MCF-7:CFR cells than six BET inhibitors in clinical trials. Transcriptomic analysis differentiated 27 from the benchmark BETi, JQ-1, showing downregulation of oncogenes and upregulation of tumor suppressors and apoptosis. The therapeutic approach was validated by oral administration of 27 in orthotopic xenografts of endocrine-resistant breast cancer in monotherapy and in combination with fulvestrant. Importantly, at an equivalent dose in rats, thrombocytopenia was mitigated.
		+
		+	Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.,Li Y, Zhao J, Gutgesell LM, Shen Z, Ratia K, Dye K, Dubrovskyi O, Zhao H, Huang F, Tonetti DA, Thatcher GRJ, Xiong R J Med Chem. 2020 Jun 15. doi: 10.1021/acs.jmedchem.0c00456. PMID:32453591<ref>PMID:32453591</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7jkz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dubrovyskyii O]]	+	[[Category: Dubrovyskyii, O]]
-	[[Category: Huang F]]	+	[[Category: Huang, F]]
-	[[Category: Li Y]]	+	[[Category: Li, Y]]
-	[[Category: Ratia KM]]	+	[[Category: Ratia, K M]]
-	[[Category: Shen Z]]	+	[[Category: Shen, Z]]
-	[[Category: Thatcher GR]]	+	[[Category: Thatcher, G R]]
-	[[Category: Xiong R]]	+	[[Category: Xiong, R]]
-	[[Category: Zhao J]]	+	[[Category: Zhao, J]]
		+	[[Category: Selective brd4-bd1 inhibitor]]
		+	[[Category: Transcription]]

OCA at 06:18, 25 August 2021

OCA — Wed, 25 Aug 2021 06:18:56 GMT

←Older revision		Revision as of 06:18, 25 August 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7jkz is ~~ON HOLD until Paper Publication~~	+	==Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with YF3-126==
-		+	<StructureSection load='7jkz' size='340' side='right'caption='[[7jkz]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JKZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jkz OCA], [https://pdbe.org/7jkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jkz RCSB], [https://www.ebi.ac.uk/pdbsum/7jkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jkz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Dubrovyskyii O]]
		+	[[Category: Huang F]]
		+	[[Category: Li Y]]
		+	[[Category: Ratia KM]]
		+	[[Category: Shen Z]]
		+	[[Category: Thatcher GR]]
		+	[[Category: Xiong R]]
		+	[[Category: Zhao J]]

OCA: Protected "7jkz" [edit=sysop:move=sysop]

OCA — Wed, 05 Aug 2020 04:18:36 GMT

Protected "7jkz" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 5 August 2020

OCA: New page: '''Unreleased structure''' The entry 7jkz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Aug 2020 04:18:35 GMT

New page: '''Unreleased structure''' The entry 7jkz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7jkz is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]