OCA at 15:06, 18 October 2023

OCA — Wed, 18 Oct 2023 15:06:25 GMT

←Older revision		Revision as of 15:06, 18 October 2023
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-	====	+	==Crystal structure of glVRC01 Fab in complex with anti-idiotype iv9 Fab==
-	<StructureSection load='7jln' size='340' side='right'caption='[[7jln]]' scene=''>	+	<StructureSection load='7jln' size='340' side='right'caption='[[7jln]], [[Resolution\|resolution]] 2.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jln]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JLN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jln OCA], [https://pdbe.org/7jln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jln RCSB], [https://www.ebi.ac.uk/pdbsum/7jln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jln ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.57Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jln OCA], [https://pdbe.org/7jln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jln RCSB], [https://www.ebi.ac.uk/pdbsum/7jln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jln ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An effective HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs). Broad and potent VRC01-class bNAbs have been isolated from multiple infected individuals, suggesting that they could be reproducibly elicited by vaccination. Several HIV-1 envelope-derived germline-targeting immunogens have been designed to engage naive VRC01-class precursor B cells. However, they also present off-target epitopes that could hinder development of VRC01-class bNAbs. We characterize a panel of anti-idiotypic monoclonal antibodies (ai-mAbs) raised against inferred-germline (iGL) VRC01-class antibodies. By leveraging binding, structural, and B cell sorting data, we engineered a bispecific molecule derived from two ai-mAbs; one specific for VRC01-class heavy chains and one specific for VRC01-class light chains. The bispecific molecule preferentially activates iGL-VRC01 B cells in vitro and induces specific antibody responses in a murine adoptive transfer model with a diverse polyclonal B cell repertoire. This molecule represents an alternative non-envelope-derived germline-targeting immunogen that can selectively activate VRC01-class precursors in vivo.
		+
		+	Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.,Seydoux E, Wan YH, Feng J, Wall A, Aljedani S, Homad LJ, MacCamy AJ, Weidle C, Gray MD, Brumage L, Taylor JJ, Pancera M, Stamatatos L, McGuire AT Cell Rep. 2021 May 4;35(5):109084. doi: 10.1016/j.celrep.2021.109084. PMID:33951425<ref>PMID:33951425</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7jln" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Pancera M]]
		+	[[Category: Weidle C]]

OCA at 10:33, 31 March 2021

OCA — Wed, 31 Mar 2021 10:33:24 GMT

←Older revision		Revision as of 10:33, 31 March 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7jln ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7jln' size='340' side='right'caption='[[7jln]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jln OCA], [https://pdbe.org/7jln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jln RCSB], [https://www.ebi.ac.uk/pdbsum/7jln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jln ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:20, 2 September 2020

OCA — Wed, 02 Sep 2020 05:20:18 GMT

←Older revision		Revision as of 05:20, 2 September 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7jln is ON HOLD	+	The entry 7jln is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7jln" [edit=sysop:move=sysop]

OCA — Wed, 05 Aug 2020 04:20:15 GMT

Protected "7jln" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:20, 5 August 2020

OCA: New page: '''Unreleased structure''' The entry 7jln is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Aug 2020 04:20:14 GMT

New page: '''Unreleased structure''' The entry 7jln is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7jln is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7jln - Revision history

OCA at 15:06, 18 October 2023

OCA at 10:33, 31 March 2021

OCA at 05:20, 2 September 2020

OCA: Protected "7jln" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7jln is ON HOLD Authors: Description: Category: Unreleased Structures