7jvg - Revision history

OCA at 15:12, 18 October 2023

OCA — Wed, 18 Oct 2023 15:12:08 GMT

←Older revision		Revision as of 15:12, 18 October 2023
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	<StructureSection load='7jvg' size='340' side='right'caption='[[7jvg]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='7jvg' size='340' side='right'caption='[[7jvg]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7jvg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JVG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jvg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JVG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=1AG:(2S)~~-2,~~3-DIHYDROXYPROPYL+(5Z,8Z,11Z,14Z)-ICOSA-5,8,11,14-TETRAENOATE'>1AG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~RBP2~~, ~~CRBP2~~ (~~[https:~~/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1AG:(2S)-2,3-DIHYDROXYPROPYL+(5Z,8Z,11Z,14Z)-ICOSA-5,8,11,14-TETRAENOATE'>1AG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jvg OCA], [https://pdbe.org/7jvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jvg RCSB], [https://www.ebi.ac.uk/pdbsum/7jvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jvg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jvg OCA], [https://pdbe.org/7jvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jvg RCSB], [https://www.ebi.ac.uk/pdbsum/7jvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jvg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN]] Intracellular transport of retinol.	+	[https://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN] Intracellular transport of retinol.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 7jvg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7jvg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Retinol-binding protein 3D structures\|Retinol-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Golczak, M]]	+	[[Category: Golczak M]]
-	[[Category: Silvaroli~~, J A]]~~	+	[[Category: Silvaroli JA]]
-	~~[[Category: Arachidonoylglycerol]]~~	+
-	~~[[Category: Lipid binding]]~~	+
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: Monoacylglycerol]]~~	+
-	~~[[Category: Retinol-binding protein~~]]	+

OCA at 07:13, 7 April 2021

OCA — Wed, 07 Apr 2021 07:13:07 GMT

←Older revision		Revision as of 07:13, 7 April 2021
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	==Cellular retinol-binding protein 2 (CRBP2) in complex with 1-arachidonoylglycerol==		==Cellular retinol-binding protein 2 (CRBP2) in complex with 1-arachidonoylglycerol==
-	<StructureSection load='7jvg' size='340' side='right'caption='[[7jvg]]' scene=''>	+	<StructureSection load='7jvg' size='340' side='right'caption='[[7jvg]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JVG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jvg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JVG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jvg OCA], [https://pdbe.org/7jvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jvg RCSB], [https://www.ebi.ac.uk/pdbsum/7jvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jvg ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1AG:(2S)-2,3-DIHYDROXYPROPYL+(5Z,8Z,11Z,14Z)-ICOSA-5,8,11,14-TETRAENOATE'>1AG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBP2, CRBP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jvg OCA], [https://pdbe.org/7jvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jvg RCSB], [https://www.ebi.ac.uk/pdbsum/7jvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jvg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN]] Intracellular transport of retinol.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Present in the small intestine, cellular retinol-binding protein 2 (CRBP2) plays an important role in the uptake, transport, and metabolism of dietary retinoids. However, the recent discovery of the interactions of CRBP2 with 2-arachidonoylglycerol (2-AG) and other monoacylglycerols (MAGs) suggests the broader involvement of this protein in lipid metabolism and signaling. To better understand the physiological role of CRBP2, we determined its protein-lipid interactome using a fluorescence-based retinol replacement assay adapted for a high-throughput screening format. By examining chemical libraries of bioactive lipids, we provided evidence for the selective interaction of CRBP2 with a subset of non-retinoid ligands with the highest affinity for sn-1 and sn-2 MAGs that contain polyunsaturated C18-C20 acyl chains. We also elucidated the structure-affinity relationship for non-retinoid ligands of this protein. We further dissect the molecular basis for this ligand's specificity by analyzing high-resolution crystal structures of CRBP2 in complex with selected derivatives of MAGs. Finally, we identify T51 and V61 as key amino acids that enable the broadening of ligand selectivity to MAGs in CRBP2 as compared to retinoid-specific CRBP1. Thus, our study provides the molecular framework for understanding the lipid selectivity and diverse functions of CRBPs in controlling lipid homeostasis.'
		+
		+	Molecular basis for the interaction of cellular retinol-binding protein 2 (CRBP2) with non-retinoid ligands.,Silvaroli JA, Plau J, Adams CH, Banerjee S, Widjaja-Adhi MAK, Blaner WS, Golczak M J Lipid Res. 2021 Feb 22:100054. doi: 10.1016/j.jlr.2021.100054. PMID:33631211<ref>PMID:33631211</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7jvg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Golczak M]]	+	[[Category: Golczak, M]]
-	[[Category: Silvaroli JA]]	+	[[Category: Silvaroli, J A]]
		+	[[Category: Arachidonoylglycerol]]
		+	[[Category: Lipid binding]]
		+	[[Category: Lipid binding protein]]
		+	[[Category: Monoacylglycerol]]
		+	[[Category: Retinol-binding protein]]

OCA at 17:21, 10 March 2021

OCA — Wed, 10 Mar 2021 17:21:00 GMT

←Older revision		Revision as of 17:21, 10 March 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7jvg ~~is ON HOLD until Paper Publication~~	+	==Cellular retinol-binding protein 2 (CRBP2) in complex with 1-arachidonoylglycerol==
-		+	<StructureSection load='7jvg' size='340' side='right'caption='[[7jvg]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JVG FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jvg OCA], [https://pdbe.org/7jvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jvg RCSB], [https://www.ebi.ac.uk/pdbsum/7jvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jvg ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Golczak M]]
		+	[[Category: Silvaroli JA]]

OCA: Protected "7jvg" [edit=sysop:move=sysop]

OCA — Wed, 02 Sep 2020 05:22:07 GMT

Protected "7jvg" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:22, 2 September 2020

OCA: New page: '''Unreleased structure''' The entry 7jvg is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Sep 2020 05:22:06 GMT

New page: '''Unreleased structure''' The entry 7jvg is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7jvg is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]