7jxa - Revision history

OCA at 10:38, 22 May 2024

OCA — Wed, 22 May 2024 10:38:19 GMT

←Older revision		Revision as of 10:38, 22 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7jxa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JXA FirstGlance]. <br>		<table><tr><td colspan='2'>[[7jxa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JXA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETX:2-ETHOXYETHANOL'>ETX</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETX:2-ETHOXYETHANOL'>ETX</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jxa OCA], [https://pdbe.org/7jxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jxa RCSB], [https://www.ebi.ac.uk/pdbsum/7jxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jxa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jxa OCA], [https://pdbe.org/7jxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jxa RCSB], [https://www.ebi.ac.uk/pdbsum/7jxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jxa ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/ARRS_BOVIN ARRS_BOVIN]] Note=S-antigen induces autoimmune uveitis.	+	[https://www.uniprot.org/uniprot/ARRS_BOVIN ARRS_BOVIN] Note=S-antigen induces autoimmune uveitis.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ARRS_BOVIN ARRS_BOVIN]] Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Isoform B plays a role in the phototransduction cascade.	+	[https://www.uniprot.org/uniprot/ARRS_BOVIN ARRS_BOVIN] Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Isoform B plays a role in the phototransduction cascade.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7jxa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7jxa" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Arrestin 3D structures\|Arrestin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kiser~~, P D~~]]	+	[[Category: Kiser PD]]
-	[[Category: Palczewski, K]]	+	[[Category: Palczewski K]]
-	[[Category: Sander~~, C L]]~~	+	[[Category: Sander CL]]
-	~~[[Category: Gpcr]]~~	+
-	~~[[Category: Inositol]]~~	+
-	~~[[Category: Inositol triphosphate]]~~	+
-	~~[[Category: Insp3]]~~	+
-	~~[[Category: Ip3]]~~	+
-	~~[[Category: Phototransduction]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Rhodopsin~~]]	+

OCA at 15:58, 3 November 2021

OCA — Wed, 03 Nov 2021 15:58:30 GMT

←Older revision		Revision as of 15:58, 3 November 2021
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	==CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH INOSITOL 1,4,5-TRIPHOSPHATE==		==CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH INOSITOL 1,4,5-TRIPHOSPHATE==
-	<StructureSection load='7jxa' size='340' side='right'caption='[[7jxa]]' scene=''>	+	<StructureSection load='7jxa' size='340' side='right'caption='[[7jxa]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JXA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jxa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JXA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jxa OCA], [https://pdbe.org/7jxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jxa RCSB], [https://www.ebi.ac.uk/pdbsum/7jxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jxa ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETX:2-ETHOXYETHANOL'>ETX</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jxa OCA], [https://pdbe.org/7jxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jxa RCSB], [https://www.ebi.ac.uk/pdbsum/7jxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jxa ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/ARRS_BOVIN ARRS_BOVIN]] Note=S-antigen induces autoimmune uveitis.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/ARRS_BOVIN ARRS_BOVIN]] Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Isoform B plays a role in the phototransduction cascade.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Visual arrestin (Arr1) terminates rhodopsin signaling by blocking its interaction with transducin. To do this, Arr1 translocates from the inner to the outer segment of photoreceptors upon light stimulation. Mounting evidence indicates that inositol phosphates (InsPs) affect Arr1 activity, but the Arr1-InsP molecular interaction remains poorly defined. We report the structure of bovine Arr1 in a ligand-free state featuring a near-complete model of the previously unresolved C-tail, which plays a crucial role in regulating Arr1 activity. InsPs bind to the N-domain basic patch thus displacing the C-tail, suggesting that they prime Arr1 for interaction with rhodopsin and help direct Arr1 translocation. These structures exhibit intact polar cores, suggesting that C-tail removal by InsP binding is insufficient to activate Arr1. These results show how Arr1 activity can be controlled by endogenous InsPs in molecular detail.
		+
		+	Structural evidence for visual arrestin priming via complexation of phosphoinositols.,Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD Structure. 2021 Oct 21. pii: S0969-2126(21)00370-1. doi:, 10.1016/j.str.2021.10.002. PMID:34678158<ref>PMID:34678158</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7jxa" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kiser PD]]	+	[[Category: Kiser, P D]]
-	[[Category: Palczewski K]]	+	[[Category: Palczewski, K]]
-	[[Category: Sander CL]]	+	[[Category: Sander, C L]]
		+	[[Category: Gpcr]]
		+	[[Category: Inositol]]
		+	[[Category: Inositol triphosphate]]
		+	[[Category: Insp3]]
		+	[[Category: Ip3]]
		+	[[Category: Phototransduction]]
		+	[[Category: Protein binding]]
		+	[[Category: Rhodopsin]]

OCA at 11:41, 13 October 2021

OCA — Wed, 13 Oct 2021 11:41:31 GMT

←Older revision		Revision as of 11:41, 13 October 2021
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-	'''Unreleased structure'''

-	~~The entry 7jxa is ON HOLD until Paper Publication~~	+	==CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH INOSITOL 1,4,5-TRIPHOSPHATE==
-		+	<StructureSection load='7jxa' size='340' side='right'caption='[[7jxa]]' scene=''>
-	~~Authors: Sander, C.L., Palczewski, K., Kiser, P.D.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JXA FirstGlance]. <br>
-	~~Description:~~ CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH INOSITOL 1,4,5-TRIPHOSPHATE	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jxa OCA], [https://pdbe.org/7jxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jxa RCSB], [https://www.ebi.ac.uk/pdbsum/7jxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jxa ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Kiser~~, P.D]]	+	__TOC__
-	[[Category: ~~Sander, C.L~~]]	+	</StructureSection>
-	[[Category: Palczewski, K]]	+	[[Category: Large Structures]]
		+	[[Category: Kiser PD]]
		+	[[Category: Palczewski K]]
		+	[[Category: Sander CL]]

OCA at 07:02, 16 September 2020

OCA — Wed, 16 Sep 2020 07:02:15 GMT

←Older revision		Revision as of 07:02, 16 September 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7jxa is ON HOLD	+	The entry 7jxa is ON HOLD until Paper Publication

	Authors: Sander, C.L., Palczewski, K., Kiser, P.D.		Authors: Sander, C.L., Palczewski, K., Kiser, P.D.
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	Description: CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH INOSITOL 1,4,5-TRIPHOSPHATE		Description: CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH INOSITOL 1,4,5-TRIPHOSPHATE
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Sander, C.L]]
	[[Category: Kiser, P.D]]		[[Category: Kiser, P.D]]
		+	[[Category: Sander, C.L]]
	[[Category: Palczewski, K]]		[[Category: Palczewski, K]]

OCA: Protected "7jxa" [edit=sysop:move=sysop]

OCA — Wed, 02 Sep 2020 05:27:11 GMT

Protected "7jxa" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:27, 2 September 2020

OCA: New page: '''Unreleased structure''' The entry 7jxa is ON HOLD Authors: Sander, C.L., Palczewski, K., Kiser, P.D. Description: CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH INOSI...

OCA — Wed, 02 Sep 2020 05:27:10 GMT

New page: '''Unreleased structure''' The entry 7jxa is ON HOLD Authors: Sander, C.L., Palczewski, K., Kiser, P.D. Description: CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH INOSI...

New page

'''Unreleased structure'''

The entry 7jxa is ON HOLD

Authors: Sander, C.L., Palczewski, K., Kiser, P.D.

Description: CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH INOSITOL 1,4,5-TRIPHOSPHATE
[[Category: Unreleased Structures]]
[[Category: Sander, C.L]]
[[Category: Kiser, P.D]]
[[Category: Palczewski, K]]