OCA at 15:13, 18 October 2023

OCA — Wed, 18 Oct 2023 15:13:44 GMT

←Older revision		Revision as of 15:13, 18 October 2023
Line 1:		Line 1:

-	====	+	==Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology==
-	<StructureSection load='7jxd' size='340' side='right'caption='[[7jxd]]' scene=''>	+	<StructureSection load='7jxd' size='340' side='right'caption='[[7jxd]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jxd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JXD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7jxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jxd OCA], [~~http~~://pdbe.org/7jxd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7jxd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7jxd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7jxd ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jxd OCA], [https://pdbe.org/7jxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jxd RCSB], [https://www.ebi.ac.uk/pdbsum/7jxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jxd ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2 infection is crucial for understanding immune protection and identifying targets for vaccine design. In a cohort of 647 SARS-CoV-2-infected subjects, we found that both the magnitude of Ab responses to SARS-CoV-2 spike (S) and nucleoprotein and nAb titers correlate with clinical scores. The receptor-binding domain (RBD) is immunodominant and the target of 90% of the neutralizing activity present in SARS-CoV-2 immune sera. Whereas overall RBD-specific serum IgG titers waned with a half-life of 49 days, nAb titers and avidity increased over time for some individuals, consistent with affinity maturation. We structurally defined an RBD antigenic map and serologically quantified serum Abs specific for distinct RBD epitopes leading to the identification of two major receptor-binding motif antigenic sites. Our results explain the immunodominance of the receptor-binding motif and will guide the design of COVID-19 vaccines and therapeutics.
		+
		+	Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.,Piccoli L, Park YJ, Tortorici MA, Czudnochowski N, Walls AC, Beltramello M, Silacci-Fregni C, Pinto D, Rosen LE, Bowen JE, Acton OJ, Jaconi S, Guarino B, Minola A, Zatta F, Sprugasci N, Bassi J, Peter A, De Marco A, Nix JC, Mele F, Jovic S, Rodriguez BF, Gupta SV, Jin F, Piumatti G, Lo Presti G, Pellanda AF, Biggiogero M, Tarkowski M, Pizzuto MS, Cameroni E, Havenar-Daughton C, Smithey M, Hong D, Lepori V, Albanese E, Ceschi A, Bernasconi E, Elzi L, Ferrari P, Garzoni C, Riva A, Snell G, Sallusto F, Fink K, Virgin HW, Lanzavecchia A, Corti D, Veesler D Cell. 2020 Sep 16. pii: S0092-8674(20)31234-4. doi: 10.1016/j.cell.2020.09.037. PMID:32991844<ref>PMID:32991844</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7jxd" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Czudnochowski N]]
		+	[[Category: Park YJ]]
		+	[[Category: Snell G]]
		+	[[Category: Tortorici MA]]
		+	[[Category: Veesler D]]
		+	[[Category: Walls AC]]

OCA at 05:53, 14 October 2020

OCA — Wed, 14 Oct 2020 05:53:09 GMT

←Older revision		Revision as of 05:53, 14 October 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7jxd ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7jxd' size='340' side='right'caption='[[7jxd]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jxd OCA], [http://pdbe.org/7jxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jxd RCSB], [http://www.ebi.ac.uk/pdbsum/7jxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jxd ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7jxd" [edit=sysop:move=sysop]

OCA — Wed, 02 Sep 2020 05:27:24 GMT

Protected "7jxd" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:27, 2 September 2020

OCA: New page: '''Unreleased structure''' The entry 7jxd is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Sep 2020 05:27:22 GMT

New page: '''Unreleased structure''' The entry 7jxd is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7jxd is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7jxd - Revision history

OCA at 15:13, 18 October 2023

OCA at 05:53, 14 October 2020

OCA: Protected "7jxd" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7jxd is ON HOLD Authors: Description: Category: Unreleased Structures