7k1e - Revision history

OCA at 15:15, 18 October 2023

OCA — Wed, 18 Oct 2023 15:15:56 GMT

←Older revision		Revision as of 15:15, 18 October 2023
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	==Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646==		==Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646==
-	<StructureSection load='7k1e' size='340' side='right'caption='[[7k1e]]' scene=''>	+	<StructureSection load='7k1e' size='340' side='right'caption='[[7k1e]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K1E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7k1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K1E FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1e OCA], [https://pdbe.org/7k1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1e RCSB], [https://www.ebi.ac.uk/pdbsum/7k1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1e ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=VQG:3,4-difluoro-N-[(1S)-1-{1-[(2R)-4-(hydroxyamino)-4-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}ethyl]benzamide'>VQG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1e OCA], [https://pdbe.org/7k1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1e RCSB], [https://www.ebi.ac.uk/pdbsum/7k1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1e ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
		+
		+	==See Also==
		+	*[[Insulin-degrading enzyme 3D structures\|Insulin-degrading enzyme 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bosc D]]		[[Category: Bosc D]]

OCA at 06:50, 22 September 2021

OCA — Wed, 22 Sep 2021 06:50:18 GMT

←Older revision		Revision as of 06:50, 22 September 2021
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-	'''Unreleased structure'''

-	~~The entry 7k1e is ON HOLD until Sep 07 2022~~	+	==Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646==
-		+	<StructureSection load='7k1e' size='340' side='right'caption='[[7k1e]]' scene=''>
-	~~Authors: Liang, W.G., Deprez, R., Bosc, D., Tang, W.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K1E FirstGlance]. <br>
-	~~Description:~~ Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1e OCA], [https://pdbe.org/7k1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1e RCSB], [https://www.ebi.ac.uk/pdbsum/7k1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1e ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Deprez~~, R]]	+	__TOC__
-	[[Category: ~~Tang, W~~]]	+	</StructureSection>
-	[[Category: Bosc, D]]	+	[[Category: Large Structures]]
-	[[Category: Liang, W.G]]	+	[[Category: Bosc D]]
		+	[[Category: Deprez R]]
		+	[[Category: Liang WG]]
		+	[[Category: Tang W]]

OCA at 04:56, 18 August 2021

OCA — Wed, 18 Aug 2021 04:56:45 GMT

←Older revision		Revision as of 04:56, 18 August 2021
Line 5:		Line 5:
	Authors: Liang, W.G., Deprez, R., Bosc, D., Tang, W.		Authors: Liang, W.G., Deprez, R., Bosc, D., Tang, W.

-	Description: Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 3	+	Description: Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bosc, D]]
-	[[Category: Liang, W.G]]
	[[Category: Deprez, R]]		[[Category: Deprez, R]]
	[[Category: Tang, W]]		[[Category: Tang, W]]
		+	[[Category: Bosc, D]]
		+	[[Category: Liang, W.G]]

OCA at 09:09, 23 September 2020

OCA — Wed, 23 Sep 2020 09:09:18 GMT

←Older revision		Revision as of 09:09, 23 September 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7k1e is ON HOLD	+	The entry 7k1e is ON HOLD until Sep 07 2022

	Authors: Liang, W.G., Deprez, R., Bosc, D., Tang, W.		Authors: Liang, W.G., Deprez, R., Bosc, D., Tang, W.
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	Description: Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 3		Description: Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 3
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Deprez, R]]
-	[[Category: Tang, W]]
	[[Category: Bosc, D]]		[[Category: Bosc, D]]
	[[Category: Liang, W.G]]		[[Category: Liang, W.G]]
		+	[[Category: Deprez, R]]
		+	[[Category: Tang, W]]

OCA: Protected "7k1e" [edit=sysop:move=sysop]

OCA — Wed, 16 Sep 2020 07:05:56 GMT

Protected "7k1e" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:05, 16 September 2020

OCA: New page: '''Unreleased structure''' The entry 7k1e is ON HOLD Authors: Liang, W.G., Deprez, R., Bosc, D., Tang, W. Description: Crystal structure of human insulin degrading enzyme (IDE) in comp...

OCA — Wed, 16 Sep 2020 07:05:55 GMT

New page: '''Unreleased structure''' The entry 7k1e is ON HOLD Authors: Liang, W.G., Deprez, R., Bosc, D., Tang, W. Description: Crystal structure of human insulin degrading enzyme (IDE) in comp...

New page

'''Unreleased structure'''

The entry 7k1e is ON HOLD

Authors: Liang, W.G., Deprez, R., Bosc, D., Tang, W.

Description: Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 3
[[Category: Unreleased Structures]]
[[Category: Deprez, R]]
[[Category: Tang, W]]
[[Category: Bosc, D]]
[[Category: Liang, W.G]]