7k1n - Revision history

OCA at 14:54, 6 March 2024

OCA — Wed, 06 Mar 2024 14:54:51 GMT

←Older revision		Revision as of 14:54, 6 March 2024
Line 1:		Line 1:

-	====	+	==CryoEM structure of inactivated-form DNA-PK (Complex V)==
-	<StructureSection load='7k1n' size='340' side='right'caption='[[7k1n]]' scene=''>	+	<StructureSection load='7k1n' size='340' side='right'caption='[[7k1n]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7k1n]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K1N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1n OCA], [https://pdbe.org/7k1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1n RCSB], [https://www.ebi.ac.uk/pdbsum/7k1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1n ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1n OCA], [https://pdbe.org/7k1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1n RCSB], [https://www.ebi.ac.uk/pdbsum/7k1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1n ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PRKDC_HUMAN PRKDC_HUMAN] Severe combined immunodeficiency due to DNA-PKcs deficiency. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PRKDC_HUMAN PRKDC_HUMAN] Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation.<ref>PMID:12649176</ref> <ref>PMID:14734805</ref> <ref>PMID:15574326</ref> <ref>PMID:9679063</ref>
		+
		+	==See Also==
		+	*[[Ku protein\|Ku protein]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: Chen X]]
		+	[[Category: Gellert M]]
		+	[[Category: Yang W]]

OCA at 15:03, 3 March 2021

OCA — Wed, 03 Mar 2021 15:03:15 GMT

←Older revision		Revision as of 15:03, 3 March 2021
Line 3:		Line 3:
	<StructureSection load='7k1n' size='340' side='right'caption='[[7k1n]]' scene=''>		<StructureSection load='7k1n' size='340' side='right'caption='[[7k1n]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7k1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1n OCA], [~~http~~://pdbe.org/7k1n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7k1n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7k1n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1n ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1n OCA], [https://pdbe.org/7k1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1n RCSB], [https://www.ebi.ac.uk/pdbsum/7k1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1n ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 08:55, 6 January 2021

OCA — Wed, 06 Jan 2021 08:55:54 GMT

←Older revision		Revision as of 08:55, 6 January 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7k1n ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7k1n' size='340' side='right'caption='[[7k1n]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7k1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1n OCA], [http://pdbe.org/7k1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7k1n RCSB], [http://www.ebi.ac.uk/pdbsum/7k1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1n ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 19:06, 28 October 2020

OCA — Wed, 28 Oct 2020 19:06:21 GMT

←Older revision		Revision as of 19:06, 28 October 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7k1n is ON HOLD	+	The entry 7k1n is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7k1n" [edit=sysop:move=sysop]

OCA — Wed, 16 Sep 2020 07:06:24 GMT

Protected "7k1n" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:06, 16 September 2020

OCA: New page: '''Unreleased structure''' The entry 7k1n is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Sep 2020 07:06:23 GMT

New page: '''Unreleased structure''' The entry 7k1n is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7k1n is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]