7k4g - Revision history

OCA at 15:17, 18 October 2023

OCA — Wed, 18 Oct 2023 15:17:21 GMT

←Older revision		Revision as of 15:17, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='7k4g' size='340' side='right'caption='[[7k4g]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='7k4g' size='340' side='right'caption='[[7k4g]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7k4g]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7k4g]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K4G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=VUV:3-[(2~{S},3~{R})-2-carboxypyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide'>VUV</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Arginase Arginase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=VUV:3-[(2~{S},3~{R})-2-carboxypyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide'>VUV</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k4g OCA], [https://pdbe.org/7k4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k4g RCSB], [https://www.ebi.ac.uk/pdbsum/7k4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k4g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k4g OCA], [https://pdbe.org/7k4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k4g RCSB], [https://www.ebi.ac.uk/pdbsum/7k4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k4g ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>	+	[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 7k4g" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7k4g" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Arginase 3D structures\|Arginase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arginase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Palte~~, R L]]~~	+	[[Category: Palte RL]]
-	~~[[Category: Arginine]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Urea cycle~~]]	+

OCA at 10:04, 8 December 2021

OCA — Wed, 08 Dec 2021 10:04:41 GMT

←Older revision		Revision as of 10:04, 8 December 2021
Line 1:		Line 1:

	==Human Arginase 1 in complex with compound 01.==		==Human Arginase 1 in complex with compound 01.==
-	<StructureSection load='7k4g' size='340' side='right'caption='[[7k4g]]' scene=''>	+	<StructureSection load='7k4g' size='340' side='right'caption='[[7k4g]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7k4g]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K4G FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k4g OCA], [https://pdbe.org/7k4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k4g RCSB], [https://www.ebi.ac.uk/pdbsum/7k4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k4g ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=VUV:3-[(2~{S},3~{R})-2-carboxypyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide'>VUV</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Arginase Arginase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k4g OCA], [https://pdbe.org/7k4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k4g RCSB], [https://www.ebi.ac.uk/pdbsum/7k4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k4g ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Comprehensive synthetic strategies afforded a diverse set of structurally unique bicyclic proline-containing arginase inhibitors with a high degree of three-dimensionality. The analogs that favored the Cgamma-exo conformation of the proline improved the arginase potency over the initial lead. The novel synthetic strategies reported here not only enable access to previously unknown stereochemically complex proline derivatives but also provide a foundation for the future synthesis of bicyclic proline analogs, which incorporate inherent three-dimensional character into building blocks, medicine, and catalysts and could have a profound impact on the conformation of proline-containing peptides and macrocycles.
		+
		+	Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.,Li D, Zhang H, Lyons TW, Lu M, Achab A, Pu Q, Childers M, Mitcheltree MJ, Wang J, Martinot TA, McMinn SE, Sloman DL, Palani A, Beard A, Nogle L, Gathiaka S, Sauri J, Kim HY, Adpressa D, Spacciapoli P, Miller JR, Palte RL, Lesburg CA, Cumming J, Fischer C ACS Med Chem Lett. 2021 Oct 13;12(11):1678-1688. doi:, 10.1021/acsmedchemlett.1c00258. eCollection 2021 Nov 11. PMID:34795856<ref>PMID:34795856</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7k4g" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arginase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Palte RL]]	+	[[Category: Palte, R L]]
		+	[[Category: Arginine]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Urea cycle]]

OCA at 06:19, 1 December 2021

OCA — Wed, 01 Dec 2021 06:19:17 GMT

←Older revision		Revision as of 06:19, 1 December 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7k4g ~~is ON HOLD until Paper Publication~~	+	==Human Arginase 1 in complex with compound 01.==
-		+	<StructureSection load='7k4g' size='340' side='right'caption='[[7k4g]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K4G FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k4g OCA], [https://pdbe.org/7k4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k4g RCSB], [https://www.ebi.ac.uk/pdbsum/7k4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k4g ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Palte RL]]

OCA at 05:21, 17 March 2021

OCA — Wed, 17 Mar 2021 05:21:02 GMT

←Older revision		Revision as of 05:21, 17 March 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7k4g is ON HOLD	+	The entry 7k4g is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7k4g" [edit=sysop:move=sysop]

OCA — Wed, 23 Sep 2020 09:13:31 GMT

Protected "7k4g" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:13, 23 September 2020

OCA: New page: '''Unreleased structure''' The entry 7k4g is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 23 Sep 2020 09:13:29 GMT

New page: '''Unreleased structure''' The entry 7k4g is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7k4g is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]