7k5e - Revision history

OCA at 15:17, 18 October 2023

OCA — Wed, 18 Oct 2023 15:17:51 GMT

←Older revision		Revision as of 15:17, 18 October 2023
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	<StructureSection load='7k5e' size='340' side='right'caption='[[7k5e]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='7k5e' size='340' side='right'caption='[[7k5e]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7k5e]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K5E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7K5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7k5e]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K5E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=VXM:4-{[(5-fluoro-2-hydroxyphenyl)methyl]amino}-1H-isoindole-1,3(2H)-dione'>VXM</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bfrB, PA3531 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=VXM:4-{[(5-fluoro-2-hydroxyphenyl)methyl]amino}-1H-isoindole-1,3(2H)-dione'>VXM</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k5e OCA], [https://pdbe.org/7k5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k5e RCSB], [https://www.ebi.ac.uk/pdbsum/7k5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k5e ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7k5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k5e OCA], [~~http~~://pdbe.org/7k5e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7k5e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7k5e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7k5e ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q9HY79_PSEAE Q9HY79_PSEAE]] Iron-storage protein (By similarity). Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex (By similarity).[PIRNR:PIRNR002560]	+	[https://www.uniprot.org/uniprot/Q9HY79_PSEAE Q9HY79_PSEAE] Iron-storage protein (By similarity). Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex (By similarity).[PIRNR:PIRNR002560]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7k5e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7k5e" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ferroxidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Annor-Gyamfi~~, J K~~]]	+	[[Category: Annor-Gyamfi JK]]
-	[[Category: Battaile~~, K P~~]]	+	[[Category: Battaile KP]]
-	[[Category: Bunce~~, R A~~]]	+	[[Category: Bunce RA]]
-	[[Category: Lovell, S]]	+	[[Category: Lovell S]]
-	[[Category: Meraz, K]]	+	[[Category: Meraz K]]
-	[[Category: Punchi-Hewage, A]]	+	[[Category: Punchi-Hewage A]]
-	[[Category: Rivera, M]]	+	[[Category: Rivera M]]
-	[[Category: Soldano, A]]	+	[[Category: Soldano A]]
-	[[Category: Yao, H]]	+	[[Category: Yao H]]
-	~~[[Category: Biofilm]]~~	+
-	~~[[Category: Electron transport]]~~	+
-	~~[[Category: Iron binding]]~~	+
-	~~[[Category: Iron mobilization]]~~	+
-	~~[[Category: Iron storage]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Protein-protein interaction inhibitor~~]]	+

OCA at 08:30, 20 January 2021

OCA — Wed, 20 Jan 2021 08:30:21 GMT

←Older revision		Revision as of 08:30, 20 January 2021
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	==1.75 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor JAG-5-7==		==1.75 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor JAG-5-7==
-	<StructureSection load='7k5e' size='340' side='right'caption='[[7k5e]]' scene=''>	+	<StructureSection load='7k5e' size='340' side='right'caption='[[7k5e]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K5E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7K5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7k5e]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K5E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7K5E FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7k5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k5e OCA], [http://pdbe.org/7k5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7k5e RCSB], [http://www.ebi.ac.uk/pdbsum/7k5e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7k5e ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=VXM:4-{[(5-fluoro-2-hydroxyphenyl)methyl]amino}-1H-isoindole-1,3(2H)-dione'>VXM</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bfrB, PA3531 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7k5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k5e OCA], [http://pdbe.org/7k5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7k5e RCSB], [http://www.ebi.ac.uk/pdbsum/7k5e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7k5e ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q9HY79_PSEAE Q9HY79_PSEAE]] Iron-storage protein (By similarity). Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex (By similarity).[PIRNR:PIRNR002560]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacteria depend on a well-regulated iron homeostasis to survive adverse environments. A key component of the iron homeostasis machinery is the compartmentalization of Fe(3+) in bacterioferritin and its subsequent mobilization as Fe(2+) to satisfy metabolic requirements. In Pseudomonas aeruginosa Fe(3+) is compartmentalized in bacterioferritin (BfrB), and its mobilization to the cytosol requires binding of a ferredoxin (Bfd) to reduce the stored Fe(3+) and release the soluble Fe(2+). Blocking the BfrB-Bfd complex in P. aeruginosa by deletion of the bfd gene triggers an irreversible accumulation of Fe(3+) in BfrB, concomitant cytosolic iron deficiency and significant impairment of biofilm development. Herein we report that small molecules developed to bind BfrB at the Bfd binding site block the BfrB-Bfd complex, inhibit the mobilization of iron from BfrB in P. aeruginosa cells, elicit a bacteriostatic effect on planktonic cells, and are bactericidal to cells embedded in mature biofilms.
		+
		+	Small Molecule Inhibitors of the Bacterioferritin (BfrB)-Ferredoxin (Bfd) Complex Kill Biofilm-Embedded Pseudomonas aeruginosa Cells.,Soldano A, Yao H, Punchi Hewage AND, Meraz K, Annor-Gyamfi JK, Bunce RA, Battaile KP, Lovell S, Rivera M ACS Infect Dis. 2020 Dec 3. doi: 10.1021/acsinfecdis.0c00669. PMID:33269912<ref>PMID:33269912</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7k5e" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ferroxidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Annor-Gyamfi JK]]	+	[[Category: Pseae]]
-	[[Category: Battaile KP]]	+	[[Category: Annor-Gyamfi, J K]]
-	[[Category: Bunce RA]]	+	[[Category: Battaile, K P]]
-	[[Category: Lovell S]]	+	[[Category: Bunce, R A]]
-	[[Category: Meraz K]]	+	[[Category: Lovell, S]]
-	[[Category: Punchi-Hewage A]]	+	[[Category: Meraz, K]]
-	[[Category: Rivera M]]	+	[[Category: Punchi-Hewage, A]]
-	[[Category: Soldano A]]	+	[[Category: Rivera, M]]
-	[[Category: Yao H]]	+	[[Category: Soldano, A]]
		+	[[Category: Yao, H]]
		+	[[Category: Biofilm]]
		+	[[Category: Electron transport]]
		+	[[Category: Iron binding]]
		+	[[Category: Iron mobilization]]
		+	[[Category: Iron storage]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Protein-protein interaction inhibitor]]

OCA at 12:36, 16 December 2020

OCA — Wed, 16 Dec 2020 12:36:22 GMT

←Older revision		Revision as of 12:36, 16 December 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7k5e is ON HOLD~~	+	==1.75 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor JAG-5-7==
-		+	<StructureSection load='7k5e' size='340' side='right'caption='[[7k5e]]' scene=''>
-	~~Authors: Lovell, S., Battaile, K.P., Soldano, A., Punchi-Hewage, A., Meraz, K., Annor-Gyamfi, J.K., Yao, H., Bunce, R.A., Rivera, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K5E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7K5E FirstGlance]. <br>
-	~~Description:~~ 1.75 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor JAG-5-7	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7k5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k5e OCA], [http://pdbe.org/7k5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7k5e RCSB], [http://www.ebi.ac.uk/pdbsum/7k5e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7k5e ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Rivera~~, M]]	+	__TOC__
-	[[Category: ~~Bunce, R.A~~]]	+	</StructureSection>
-	[[Category: ~~Battaile, K.P~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Yao, H~~]]	+	[[Category: Annor-Gyamfi JK]]
-	[[Category: ~~Soldano, A~~]]	+	[[Category: Battaile KP]]
-	[[Category: ~~Annor-Gyamfi, J.K~~]]	+	[[Category: Bunce RA]]
-	[[Category: Meraz, K]]	+	[[Category: Lovell S]]
-	[[Category: ~~Lovell, S~~]]	+	[[Category: Meraz K]]
-	[[Category: ~~Punchi-Hewage,~~ A]]	+	[[Category: Punchi-Hewage A]]
		+	[[Category: Rivera M]]
		+	[[Category: Soldano A]]
		+	[[Category: Yao H]]

OCA: Protected "7k5e" [edit=sysop:move=sysop]

OCA — Wed, 23 Sep 2020 09:16:00 GMT

Protected "7k5e" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:16, 23 September 2020

OCA: New page: '''Unreleased structure''' The entry 7k5e is ON HOLD Authors: Lovell, S., Battaile, K.P., Soldano, A., Punchi-Hewage, A., Meraz, K., Annor-Gyamfi, J.K., Yao, H., Bunce, R.A., Rivera, M....

OCA — Wed, 23 Sep 2020 09:15:59 GMT

New page: '''Unreleased structure''' The entry 7k5e is ON HOLD Authors: Lovell, S., Battaile, K.P., Soldano, A., Punchi-Hewage, A., Meraz, K., Annor-Gyamfi, J.K., Yao, H., Bunce, R.A., Rivera, M....

New page

'''Unreleased structure'''

The entry 7k5e is ON HOLD

Authors: Lovell, S., Battaile, K.P., Soldano, A., Punchi-Hewage, A., Meraz, K., Annor-Gyamfi, J.K., Yao, H., Bunce, R.A., Rivera, M.

Description: 1.75 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor JAG-5-7
[[Category: Unreleased Structures]]
[[Category: Rivera, M]]
[[Category: Bunce, R.A]]
[[Category: Battaile, K.P]]
[[Category: Yao, H]]
[[Category: Soldano, A]]
[[Category: Annor-Gyamfi, J.K]]
[[Category: Meraz, K]]
[[Category: Lovell, S]]
[[Category: Punchi-Hewage, A]]