7kgq - Revision history

OCA at 15:24, 18 October 2023

OCA — Wed, 18 Oct 2023 15:24:37 GMT

←Older revision		Revision as of 15:24, 18 October 2023
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-	====	+	==Crystal Structure of HLA-A*0201in complex with SARS-CoV-2 N222-230==
-	<StructureSection load='7kgq' size='340' side='right'caption='[[7kgq]]' scene=''>	+	<StructureSection load='7kgq' size='340' side='right'caption='[[7kgq]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7kgq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KGQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kgq OCA], [https://pdbe.org/7kgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kgq RCSB], [https://www.ebi.ac.uk/pdbsum/7kgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kgq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.34Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kgq OCA], [https://pdbe.org/7kgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kgq RCSB], [https://www.ebi.ac.uk/pdbsum/7kgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kgq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q861F7_HUMAN Q861F7_HUMAN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CD8+ T cells are crucial for anti-viral immunity; however, understanding T cell responses requires the identification of epitopes presented by human leukocyte antigens (HLA). To date, few SARS-CoV-2-specific CD8+ T cell epitopes have been described. Internal viral proteins are typically more conserved than surface proteins and are often the target of CD8+ T cells. Therefore, we have characterized eight peptides derived from the internal SARS-CoV-2 nucleocapsid protein predicted to bind HLA-A( )02:01, the most common HLA molecule in the global population. We determined not all peptides could form a complex with HLA-A( )02:01, and the six crystal structures determined revealed that some peptides adopted a mobile conformation. We therefore provide a molecular understanding of SARS-CoV-2 CD8+ T cell epitopes. Furthermore, we show that there is limited pre-existing CD8+ T cell response toward these epitopes in unexposed individuals. Together, these data show that SARS-CoV-2 nucleocapsid might not contain potent epitopes restricted to HLA-A( *)02:01.
		+
		+	The presentation of SARS-CoV-2 peptides by the common HLA-A( *)02:01 molecule.,Szeto C, Chatzileontiadou DSM, Nguyen AT, Sloane H, Lobos CA, Jayasinghe D, Halim H, Smith C, Riboldi-Tunnicliffe A, Grant EJ, Gras S iScience. 2021 Feb 19;24(2):102096. doi: 10.1016/j.isci.2021.102096. Epub 2021 , Jan 22. PMID:33521593<ref>PMID:33521593</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7kgq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Chatzileontiadou DSM]]
		+	[[Category: Gras S]]
		+	[[Category: Riboldi-Tunnicliffe A]]
		+	[[Category: Szeto C]]

OCA at 10:05, 17 February 2021

OCA — Wed, 17 Feb 2021 10:05:47 GMT

←Older revision		Revision as of 10:05, 17 February 2021
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	<StructureSection load='7kgq' size='340' side='right'caption='[[7kgq]]' scene=''>		<StructureSection load='7kgq' size='340' side='right'caption='[[7kgq]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kgq OCA], [~~http~~://pdbe.org/7kgq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7kgq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7kgq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7kgq ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kgq OCA], [https://pdbe.org/7kgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kgq RCSB], [https://www.ebi.ac.uk/pdbsum/7kgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kgq ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 08:14, 20 January 2021

OCA — Wed, 20 Jan 2021 08:14:52 GMT

←Older revision		Revision as of 08:14, 20 January 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7kgq ~~is ON HOLD until Oct 18 2022~~	+	====
-		+	<StructureSection load='7kgq' size='340' side='right'caption='[[7kgq]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kgq OCA], [http://pdbe.org/7kgq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7kgq RCSB], [http://www.ebi.ac.uk/pdbsum/7kgq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7kgq ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:30, 25 November 2020

OCA — Wed, 25 Nov 2020 05:30:01 GMT

←Older revision		Revision as of 05:30, 25 November 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7kgq is ON HOLD	+	The entry 7kgq is ON HOLD until Oct 18 2022

	Authors:		Authors:

OCA: Protected "7kgq" [edit=sysop:move=sysop]

OCA — Wed, 28 Oct 2020 19:10:55 GMT

Protected "7kgq" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:10, 28 October 2020

OCA: New page: '''Unreleased structure''' The entry 7kgq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Oct 2020 19:10:54 GMT

New page: '''Unreleased structure''' The entry 7kgq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7kgq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]