7koh - Revision history

OCA at 09:19, 25 October 2023

OCA — Wed, 25 Oct 2023 09:19:06 GMT

←Older revision		Revision as of 09:19, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7koh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KOH FirstGlance]. <br>		<table><tr><td colspan='2'>[[7koh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KOH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.98Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7koh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7koh OCA], [https://pdbe.org/7koh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7koh RCSB], [https://www.ebi.ac.uk/pdbsum/7koh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7koh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7koh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7koh OCA], [https://pdbe.org/7koh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7koh RCSB], [https://www.ebi.ac.uk/pdbsum/7koh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7koh ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:32, 22 March 2023

OCA — Wed, 22 Mar 2023 07:32:24 GMT

←Older revision		Revision as of 07:32, 22 March 2023
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	==Crystal structure of antigen 43 from Escherichia coli EDL933==		==Crystal structure of antigen 43 from Escherichia coli EDL933==
-	<StructureSection load='7koh' size='340' side='right'caption='[[7koh]]' scene=''>	+	<StructureSection load='7koh' size='340' side='right'caption='[[7koh]], [[Resolution\|resolution]] 2.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KOH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7koh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KOH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7koh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7koh OCA], [https://pdbe.org/7koh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7koh RCSB], [https://www.ebi.ac.uk/pdbsum/7koh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7koh ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7koh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7koh OCA], [https://pdbe.org/7koh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7koh RCSB], [https://www.ebi.ac.uk/pdbsum/7koh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7koh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8X9L4_ECO57 Q8X9L4_ECO57]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The formation of aggregates and biofilms enhances bacterial colonisation and infection progression by affording protection from antibiotics and host immune factors. Despite these advantages there is a trade-off, whereby bacterial dissemination is reduced. As such, biofilm development needs to be controlled to suit adaptation to different environments. Here we investigate members from one of largest groups of bacterial adhesins, the autotransporters, for their critical role in the assembly of bacterial aggregates and biofilms. We describe the structural and functional characterisation of autotransporter Ag43 variants from different Escherichia coli pathotypes. We show that specific interactions between amino acids on the contacting interfaces of adjacent Ag43 proteins drives a common mode of trans-association that leads to cell clumping. Furthermore, subtle variation of these interactions alters aggregation kinetics and the degree of compacting within cell clusters. Together, our structure-function investigation reveals an underlying molecular basis for variations in the density of bacterial communities.
		+
		+	Variation of Antigen 43 self-association modulates bacterial compacting within aggregates and biofilms.,Vo JL, Ortiz GCM, Totsika M, Lo AW, Hancock SJ, Whitten AE, Hor L, Peters KM, Ageorges V, Caccia N, Desvaux M, Schembri MA, Paxman JJ, Heras B NPJ Biofilms Microbiomes. 2022 Apr 8;8(1):20. doi: 10.1038/s41522-022-00284-1. PMID:35396507<ref>PMID:35396507</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7koh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli O157:H7]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Heras B]]		[[Category: Heras B]]
	[[Category: Paxman JJ]]		[[Category: Paxman JJ]]
	[[Category: Vo JL]]		[[Category: Vo JL]]

OCA at 06:05, 9 March 2022

OCA — Wed, 09 Mar 2022 06:05:23 GMT

←Older revision		Revision as of 06:05, 9 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7koh is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of antigen 43 from Escherichia coli EDL933==
-		+	<StructureSection load='7koh' size='340' side='right'caption='[[7koh]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KOH FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7koh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7koh OCA], [https://pdbe.org/7koh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7koh RCSB], [https://www.ebi.ac.uk/pdbsum/7koh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7koh ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Heras B]]
		+	[[Category: Paxman JJ]]
		+	[[Category: Vo JL]]

OCA at 11:11, 16 December 2020

OCA — Wed, 16 Dec 2020 11:11:26 GMT

←Older revision		Revision as of 11:11, 16 December 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7koh is ON HOLD	+	The entry 7koh is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7koh" [edit=sysop:move=sysop]

OCA — Wed, 18 Nov 2020 08:10:04 GMT

Protected "7koh" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:10, 18 November 2020

OCA: New page: '''Unreleased structure''' The entry 7koh is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Nov 2020 08:10:02 GMT

New page: '''Unreleased structure''' The entry 7koh is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7koh is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]