7ktw - Revision history

OCA at 14:57, 6 March 2024

OCA — Wed, 06 Mar 2024 14:57:49 GMT

←Older revision		Revision as of 14:57, 6 March 2024
Line 1:		Line 1:

	==Cryogenic electron microscopy model of full-length human metavinculin H1'-parallel conformation 2==		==Cryogenic electron microscopy model of full-length human metavinculin H1'-parallel conformation 2==
-	<StructureSection load='7ktw' size='340' side='right'caption='[[7ktw]]' scene=''>	+	<StructureSection load='7ktw' size='340' side='right'caption='[[7ktw]], [[Resolution\|resolution]] 4.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KTW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ktw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KTW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ktw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ktw OCA], [https://pdbe.org/7ktw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ktw RCSB], [https://www.ebi.ac.uk/pdbsum/7ktw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ktw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.27Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ktw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ktw OCA], [https://pdbe.org/7ktw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ktw RCSB], [https://www.ebi.ac.uk/pdbsum/7ktw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ktw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/VINC_HUMAN VINC_HUMAN] Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) [MIM:[https://omim.org/entry/611407 611407]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:11815424</ref> <ref>PMID:16236538</ref> Defects in VCL are the cause of familial hypertrophic cardiomyopathy type 15 (CMH15) [MIM:[https://omim.org/entry/613255 613255]. It is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:16712796</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/VINC_HUMAN VINC_HUMAN] Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.<ref>PMID:20484056</ref>
		+
		+	==See Also==
		+	*[[Vinculin\|Vinculin]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Izard T]]		[[Category: Izard T]]
	[[Category: Rangarajan ES]]		[[Category: Rangarajan ES]]

OCA at 07:58, 27 January 2021

OCA — Wed, 27 Jan 2021 07:58:54 GMT

←Older revision		Revision as of 07:58, 27 January 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7ktw ~~is ON HOLD until Paper Publication~~	+	==Cryogenic electron microscopy model of full-length human metavinculin H1'-parallel conformation 2==
-		+	<StructureSection load='7ktw' size='340' side='right'caption='[[7ktw]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KTW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ktw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ktw OCA], [https://pdbe.org/7ktw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ktw RCSB], [https://www.ebi.ac.uk/pdbsum/7ktw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ktw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Izard T]]
		+	[[Category: Rangarajan ES]]

OCA at 05:27, 30 December 2020

OCA — Wed, 30 Dec 2020 05:27:19 GMT

←Older revision		Revision as of 05:27, 30 December 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ktw is ON HOLD	+	The entry 7ktw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ktw" [edit=sysop:move=sysop]

OCA — Wed, 02 Dec 2020 05:53:44 GMT

Protected "7ktw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:53, 2 December 2020

OCA: New page: '''Unreleased structure''' The entry 7ktw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Dec 2020 05:53:43 GMT

New page: '''Unreleased structure''' The entry 7ktw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ktw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]