7kyl - Revision history

OCA at 15:34, 18 October 2023

OCA — Wed, 18 Oct 2023 15:34:07 GMT

←Older revision		Revision as of 15:34, 18 October 2023
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-	====	+	==Powassan virus Envelope protein DIII in complex with neutralizing Fab POWV-80==
-	<StructureSection load='7kyl' size='340' side='right'caption='[[7kyl]]' scene=''>	+	<StructureSection load='7kyl' size='340' side='right'caption='[[7kyl]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7kyl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Deer_tick_virus Deer tick virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KYL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kyl OCA], [https://pdbe.org/7kyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kyl RCSB], [https://www.ebi.ac.uk/pdbsum/7kyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kyl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kyl OCA], [https://pdbe.org/7kyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kyl RCSB], [https://www.ebi.ac.uk/pdbsum/7kyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kyl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/E2I7G7_9FLAV E2I7G7_9FLAV] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although Powassan virus (POWV) is an emerging tick-transmitted flavivirus that causes severe or fatal neuroinvasive disease in humans, medical countermeasures have not yet been developed. Here, we developed a panel of neutralizing anti-POWV mAbs recognizing six distinct antigenic sites. The most potent of these mAbs bind sites within domain II or III of the envelope (E) protein and inhibit postattachment viral entry steps. A subset of these mAbs cross-react with other flaviviruses. Both POWV type-specific and cross-reactive neutralizing mAbs confer protection in mice against POWV infection when given as prophylaxis or postexposure therapy. Several cross-reactive mAbs mapping to either domain II or III also protect in vivo against heterologous tick-transmitted flaviviruses including Langat and tick-borne encephalitis virus. Our experiments define structural and functional correlates of antibody protection against POWV infection and identify epitopes targeted by broadly neutralizing antibodies with therapeutic potential against multiple tick-borne flaviviruses.
		+
		+	Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses.,VanBlargan LA, Errico JM, Kafai NM, Burgomaster KE, Jethva PN, Broeckel RM, Meade-White K, Nelson CA, Himansu S, Wang D, Handley SA, Gross ML, Best SM, Pierson TC, Fremont DH, Diamond MS J Exp Med. 2021 May 3;218(5):e20210174. doi: 10.1084/jem.20210174. PMID:33831142<ref>PMID:33831142</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7kyl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Deer tick virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Errico JM]]
		+	[[Category: Fremont DH]]
		+	[[Category: Nelson CA]]

OCA at 06:52, 7 April 2021

OCA — Wed, 07 Apr 2021 06:52:48 GMT

←Older revision		Revision as of 06:52, 7 April 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7kyl ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7kyl' size='340' side='right'caption='[[7kyl]]' scene=''>
-	~~Authors~~: ~~Errico, J~~.M.~~, Nelson, C~~.A.~~, Fremont, D~~.H.~~, Center for Structural Genomics of Infectious Diseases (CSGID)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Powassan virus Envelope protein DIII in complex with neutralizing Fab POWV-80~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kyl OCA], [https://pdbe.org/7kyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kyl RCSB], [https://www.ebi.ac.uk/pdbsum/7kyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kyl ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Fremont~~, D.H]]	+	__TOC__
-	[~~[Category~~: ~~Errico, J~~.M]]	+	</StructureSection>
-	[[Category: ~~Center For Structural Genomics Of Infectious Diseases (Csgid)~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Nelson, C.A~~]]	+	[[Category: Z-disk]]

OCA at 09:19, 31 March 2021

OCA — Wed, 31 Mar 2021 09:19:41 GMT

←Older revision		Revision as of 09:19, 31 March 2021
Line 3:		Line 3:
	The entry 7kyl is ON HOLD		The entry 7kyl is ON HOLD

-	Authors:	+	Authors: Errico, J.M., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID)

-	Description:	+	Description: Powassan virus Envelope protein DIII in complex with neutralizing Fab POWV-80
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Fremont, D.H]]
		+	[[Category: Errico, J.M]]
		+	[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
		+	[[Category: Nelson, C.A]]

OCA: Protected "7kyl" [edit=sysop:move=sysop]

OCA — Wed, 16 Dec 2020 11:15:52 GMT

Protected "7kyl" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:15, 16 December 2020

OCA: New page: '''Unreleased structure''' The entry 7kyl is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Dec 2020 11:15:50 GMT

New page: '''Unreleased structure''' The entry 7kyl is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7kyl is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]