7kyo - Revision history

OCA at 15:34, 18 October 2023

OCA — Wed, 18 Oct 2023 15:34:08 GMT

←Older revision		Revision as of 15:34, 18 October 2023
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-	====	+	==PsaBC from Streptococcus pneumoniae in complex with Fab==
-	<StructureSection load='7kyo' size='340' side='right'caption='[[7kyo]]' scene=''>	+	<StructureSection load='7kyo' size='340' side='right'caption='[[7kyo]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7kyo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_D39 Streptococcus pneumoniae D39]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KYO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kyo OCA], [https://pdbe.org/7kyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kyo RCSB], [https://www.ebi.ac.uk/pdbsum/7kyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kyo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.85Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kyo OCA], [https://pdbe.org/7kyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kyo RCSB], [https://www.ebi.ac.uk/pdbsum/7kyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kyo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H2ZNF3_STRP2 A0A0H2ZNF3_STRP2]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC) permeases serve as the primary import pathway for many micronutrients including the first-row transition metal manganese. However, the structural features of ionic metal transporting ABC permeases have remained undefined. Here, we present the crystal structure of the manganese transporter PsaBC from Streptococcus pneumoniae in an open-inward conformation. The type II transporter has a tightly closed transmembrane channel due to "extracellular gating" residues that prevent water permeation or ion reflux. Below these residues, the channel contains a hitherto unreported metal coordination site, which is essential for manganese translocation. Mutagenesis of the extracellular gate perturbs manganese uptake, while coordination site mutagenesis abolishes import. These structural features are highly conserved in metal-specific ABC transporters and are represented throughout the kingdoms of life. Collectively, our results define the structure of PsaBC and reveal the features required for divalent cation transport.
		+
		+	The structural basis of bacterial manganese import.,Neville SL, Sjohamn J, Watts JA, MacDermott-Opeskin H, Fairweather SJ, Ganio K, Carey Hulyer A, McGrath AP, Hayes AJ, Malcolm TR, Davies MR, Nomura N, Iwata S, O'Mara ML, Maher MJ, McDevitt CA Sci Adv. 2021 Aug 6;7(32):eabg3980. doi: 10.1126/sciadv.abg3980. Print 2021 Aug. PMID:34362732<ref>PMID:34362732</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7kyo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ABC transporter 3D structures\|ABC transporter 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Streptococcus pneumoniae D39]]
		+	[[Category: Maher MJ]]
		+	[[Category: Sjohamn J]]

OCA at 06:19, 25 August 2021

OCA — Wed, 25 Aug 2021 06:19:06 GMT

←Older revision		Revision as of 06:19, 25 August 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7kyo ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7kyo' size='340' side='right'caption='[[7kyo]]' scene=''>
-	~~Authors~~: ~~Maher, M~~.J.~~, Sjohamn, J~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~PsaBC from Streptococcus pneumoniae in complex with Fab~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kyo OCA], [https://pdbe.org/7kyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kyo RCSB], [https://www.ebi.ac.uk/pdbsum/7kyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kyo ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Maher~~, M.J]]	+	__TOC__
-	[[Category: ~~Sjohamn, J~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:48, 6 January 2021

OCA — Wed, 06 Jan 2021 05:48:42 GMT

←Older revision		Revision as of 05:48, 6 January 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7kyo is ON HOLD	+	The entry 7kyo is ON HOLD until Paper Publication

	Authors: Maher, M.J., Sjohamn, J.		Authors: Maher, M.J., Sjohamn, J.

OCA: Protected "7kyo" [edit=sysop:move=sysop]

OCA — Wed, 16 Dec 2020 11:15:59 GMT

Protected "7kyo" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:15, 16 December 2020

OCA: New page: '''Unreleased structure''' The entry 7kyo is ON HOLD Authors: Maher, M.J., Sjohamn, J. Description: PsaBC from Streptococcus pneumoniae in complex with Fab [[Category: Unreleased Struc...

OCA — Wed, 16 Dec 2020 11:15:58 GMT

New page: '''Unreleased structure''' The entry 7kyo is ON HOLD Authors: Maher, M.J., Sjohamn, J. Description: PsaBC from Streptococcus pneumoniae in complex with Fab [[Category: Unreleased Struc...

New page

'''Unreleased structure'''

The entry 7kyo is ON HOLD

Authors: Maher, M.J., Sjohamn, J.

Description: PsaBC from Streptococcus pneumoniae in complex with Fab
[[Category: Unreleased Structures]]
[[Category: Maher, M.J]]
[[Category: Sjohamn, J]]