7l53 - Revision history

OCA at 11:14, 14 June 2023

OCA — Wed, 14 Jun 2023 11:14:21 GMT

←Older revision		Revision as of 11:14, 14 June 2023
Line 1:		Line 1:

	==Solution NMR structure of the monomeric form of the cyclic plant protein PDP-23 in CD3CN/H2O==		==Solution NMR structure of the monomeric form of the cyclic plant protein PDP-23 in CD3CN/H2O==
-	<StructureSection load='7l53' size='340' side='right'caption='[[7l53~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='7l53' size='340' side='right'caption='[[7l53]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7l53]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L53 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7l53]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zinnia_elegans Zinnia elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L53 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7l51\|7l51]], [[7l55\|7l55]], [[7l54\|7l54]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l53 OCA], [https://pdbe.org/7l53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l53 RCSB], [https://www.ebi.ac.uk/pdbsum/7l53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l53 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l53 OCA], [https://pdbe.org/7l53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l53 RCSB], [https://www.ebi.ac.uk/pdbsum/7l53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l53 ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Payne, C D~~]]	+	[[Category: Zinnia elegans]]
-	[[Category: ~~Rosengren, K J~~]]	+	[[Category: Payne CD]]
-	[[Category: ~~Hydrophobic core]]~~	+	[[Category: Rosengren KJ]]
-	~~[[Category: Macrocyclic peptide]]~~	+
-	~~[[Category: Plant protein~~]]	+

OCA at 12:33, 9 June 2021

OCA — Wed, 09 Jun 2021 12:33:57 GMT

←Older revision		Revision as of 12:33, 9 June 2021
Line 1:		Line 1:

	==Solution NMR structure of the monomeric form of the cyclic plant protein PDP-23 in CD3CN/H2O==		==Solution NMR structure of the monomeric form of the cyclic plant protein PDP-23 in CD3CN/H2O==
-	<StructureSection load='7l53' size='340' side='right'caption='[[7l53]]' scene=''>	+	<StructureSection load='7l53' size='340' side='right'caption='[[7l53]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L53 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7L53 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7l53]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L53 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7l53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l53 OCA], [~~http~~://pdbe.org/7l53 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7l53 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7l53 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7l53 ProSAT]</span></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7l51\|7l51]], [[7l55\|7l55]], [[7l54\|7l54]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l53 OCA], [https://pdbe.org/7l53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l53 RCSB], [https://www.ebi.ac.uk/pdbsum/7l53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l53 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Head-to-tail cyclized peptides are intriguing natural products with unusual properties. The PawS-Derived Peptides (PDPs) are ribosomally synthesized as part of precursors for seed storage albumins in species of the daisy family, and are post-translationally excised and cyclized during proteolytic processing. Here we report a PDP twice the typical size and with two disulfide bonds, identified from seeds of Zinnia elegans. In water, synthetic PDP-23 forms a unique dimeric structure in which two monomers containing two beta-hairpins cross-clasp and enclose a hydrophobic core, creating a square prism. This dimer can be split by addition of micelles or organic solvent and in monomeric form PDP-23 adopts open or closed V-shapes, exposing different levels of hydrophobicity dependent on conditions. This chameleonic character is unusual for disulfide-rich peptides and engenders PDP-23 with potential for cell delivery and accessing novel targets. We demonstrate this by conjugating a rhodamine dye to PDP-23, creating a stable, cell-penetrating inhibitor of the P-glycoprotein drug efflux pump.
		+
		+	A chameleonic macrocyclic peptide with drug delivery applications.,Payne CD, Franke B, Fisher MF, Hajiaghaalipour F, McAleese CE, Song A, Eliasson C, Zhang J, Jayasena AS, Vadlamani G, Clark RJ, Minchin RF, Mylne JS, Rosengren KJ Chem Sci. 2021 Apr 11;12(19):6670-6683. doi: 10.1039/d1sc00692d. PMID:34040741<ref>PMID:34040741</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7l53" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Payne CD]]	+	[[Category: Payne, C D]]
-	[[Category: Rosengren KJ]]	+	[[Category: Rosengren, K J]]
		+	[[Category: Hydrophobic core]]
		+	[[Category: Macrocyclic peptide]]
		+	[[Category: Plant protein]]

OCA at 08:15, 20 January 2021

OCA — Wed, 20 Jan 2021 08:15:27 GMT

←Older revision		Revision as of 08:15, 20 January 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7l53 is ON HOLD~~	+	==Solution NMR structure of the monomeric form of the cyclic plant protein PDP-23 in CD3CN/H2O==
-		+	<StructureSection load='7l53' size='340' side='right'caption='[[7l53]]' scene=''>
-	~~Authors: Payne, C.D., Rosengren, K.J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L53 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7L53 FirstGlance]. <br>
-	~~Description:~~ Solution NMR structure of the monomeric form of the cyclic plant protein PDP-23 in CD3CN/H2O	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7l53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l53 OCA], [http://pdbe.org/7l53 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7l53 RCSB], [http://www.ebi.ac.uk/pdbsum/7l53 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7l53 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Rosengren~~, K.J]]	+	__TOC__
-	[[Category: Payne~~, C.D~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Payne CD]]
		+	[[Category: Rosengren KJ]]

OCA: Protected "7l53" [edit=sysop:move=sysop]

OCA — Wed, 30 Dec 2020 05:31:00 GMT

Protected "7l53" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:31, 30 December 2020

OCA: New page: '''Unreleased structure''' The entry 7l53 is ON HOLD Authors: Payne, C.D., Rosengren, K.J. Description: Solution NMR structure of the monomeric form of the cyclic plant protein PDP-23 ...

OCA — Wed, 30 Dec 2020 05:30:59 GMT

New page: '''Unreleased structure''' The entry 7l53 is ON HOLD Authors: Payne, C.D., Rosengren, K.J. Description: Solution NMR structure of the monomeric form of the cyclic plant protein PDP-23 ...

New page

'''Unreleased structure'''

The entry 7l53 is ON HOLD

Authors: Payne, C.D., Rosengren, K.J.

Description: Solution NMR structure of the monomeric form of the cyclic plant protein PDP-23 in CD3CN/H2O
[[Category: Unreleased Structures]]
[[Category: Rosengren, K.J]]
[[Category: Payne, C.D]]