OCA at 15:38, 18 October 2023

OCA — Wed, 18 Oct 2023 15:38:49 GMT

←Older revision		Revision as of 15:38, 18 October 2023
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	==C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Lewis-a==		==C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Lewis-a==
-	<StructureSection load='7l64' size='340' side='right'caption='[[7l64]]' scene=''>	+	<StructureSection load='7l64' size='340' side='right'caption='[[7l64]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L64 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7l64]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L64 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l64 OCA], [https://pdbe.org/7l64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l64 RCSB], [https://www.ebi.ac.uk/pdbsum/7l64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l64 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l64 OCA], [https://pdbe.org/7l64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l64 RCSB], [https://www.ebi.ac.uk/pdbsum/7l64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l64 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MRC1_HUMAN MRC1_HUMAN] Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human mannose receptor expressed on macrophages and hepatic endothelial cells scavenges released lysosomal enzymes, glycopeptide fragments of collagen, and pathogenic microorganisms and thus reduces damage following tissue injury. The receptor binds mannose, fucose, or N-acetylglucosamine (GlcNAc) residues on these targets. C-type carbohydrate-recognition domain 4 (CRD4) of the receptor contains the site for Ca(2+)-dependent interaction with sugars. To investigate the details of CRD4 binding, glycan array screening was used to identify oligosaccharide ligands. The strongest signals were for glycans that contain either Manalpha1-2Man constituents or fucose in various linkages. The mechanisms of binding to monosaccharides and oligosaccharide substructures present in many of these ligands were examined in multiple crystal structures of CRD4. Binding of mannose residues to CRD4 results primarily from interaction of the equatorial 3- and 4-OH groups with a conserved principal Ca(2+) common to almost all sugar-binding C-type CRDs. In the Manalpha1-2Man complex, supplementary interactions with the reducing mannose residue explain the enhanced affinity for this disaccharide. Bound GlcNAc also interacts with the principal Ca(2+) through equatorial 3- and 4-OH groups, whereas fucose residues can bind in several orientations, through either the 2- and 3-OH groups or the 3- and 4-OH groups. Secondary contacts with additional sugars in fucose-containing oligosaccharides, such as the Lewis-a trisaccharide, provide enhanced affinity for these glycans. These results explain many of the biologically important interactions of the mannose receptor with both mammalian glycoproteins and microbes such as yeast and suggest additional classes of ligands that have not been previously identified.
		+
		+	Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206.,Feinberg H, Jegouzo SAF, Lasanajak Y, Smith DF, Drickamer K, Weis WI, Taylor ME J Biol Chem. 2021 Jan-Jun;296:100368. doi: 10.1016/j.jbc.2021.100368. Epub 2021 , Feb 2. PMID:33545173<ref>PMID:33545173</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7l64" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Feinberg H]]		[[Category: Feinberg H]]
	[[Category: Weis WI]]		[[Category: Weis WI]]

OCA at 11:13, 3 February 2021

OCA — Wed, 03 Feb 2021 11:13:11 GMT

←Older revision		Revision as of 11:13, 3 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7l64 ~~is ON HOLD until Paper Publication~~	+	==C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Lewis-a==
-		+	<StructureSection load='7l64' size='340' side='right'caption='[[7l64]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L64 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l64 OCA], [https://pdbe.org/7l64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l64 RCSB], [https://www.ebi.ac.uk/pdbsum/7l64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l64 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Feinberg H]]
		+	[[Category: Weis WI]]

OCA at 06:45, 27 January 2021

OCA — Wed, 27 Jan 2021 06:45:04 GMT

←Older revision		Revision as of 06:45, 27 January 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7l64 is ON HOLD	+	The entry 7l64 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7l64" [edit=sysop:move=sysop]

OCA — Wed, 30 Dec 2020 05:32:53 GMT

Protected "7l64" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:32, 30 December 2020

OCA: New page: '''Unreleased structure''' The entry 7l64 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 30 Dec 2020 05:32:52 GMT

New page: '''Unreleased structure''' The entry 7l64 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7l64 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7l64 - Revision history

OCA at 15:38, 18 October 2023

OCA at 11:13, 3 February 2021

OCA at 06:45, 27 January 2021

OCA: Protected "7l64" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7l64 is ON HOLD Authors: Description: Category: Unreleased Structures