7l6k - Revision history

OCA at 11:14, 14 June 2023

OCA — Wed, 14 Jun 2023 11:14:29 GMT

←Older revision		Revision as of 11:14, 14 June 2023
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	==ApoL1 N-terminal domain==		==ApoL1 N-terminal domain==
-	<StructureSection load='7l6k' size='340' side='right'caption='[[7l6k~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='7l6k' size='340' side='right'caption='[[7l6k]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7l6k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7l6k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L6K FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APOL1, APOL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l6k OCA], [https://pdbe.org/7l6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l6k RCSB], [https://www.ebi.ac.uk/pdbsum/7l6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l6k ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l6k OCA], [https://pdbe.org/7l6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l6k RCSB], [https://www.ebi.ac.uk/pdbsum/7l6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l6k ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN]] Genetic steroid-resistant nephrotic syndrome. The disease is caused by variants affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN] Genetic steroid-resistant nephrotic syndrome. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN]] May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.	+	[https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN] May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fairbrother~~, W J~~]]	+	[[Category: Fairbrother WJ]]
-	[[Category: Holliday~~, M J~~]]	+	[[Category: Holliday MJ]]
-	[[Category: Kirchhofer, D]]	+	[[Category: Kirchhofer D]]
-	[[Category: Moran, P]]	+	[[Category: Moran P]]
-	[[Category: Ultsch, M]]	+	[[Category: Ultsch M]]
-	~~[[Category: Ion channel]]~~	+
-	~~[[Category: Kidney disease]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 06:32, 25 August 2021

OCA — Wed, 25 Aug 2021 06:32:22 GMT

←Older revision		Revision as of 06:32, 25 August 2021
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	==ApoL1 N-terminal domain==		==ApoL1 N-terminal domain==
-	<StructureSection load='7l6k' size='340' side='right'caption='[[7l6k]]' scene=''>	+	<StructureSection load='7l6k' size='340' side='right'caption='[[7l6k]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7l6k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L6K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l6k OCA], [https://pdbe.org/7l6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l6k RCSB], [https://www.ebi.ac.uk/pdbsum/7l6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l6k ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APOL1, APOL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l6k OCA], [https://pdbe.org/7l6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l6k RCSB], [https://www.ebi.ac.uk/pdbsum/7l6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l6k ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN]] Genetic steroid-resistant nephrotic syndrome. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN]] May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Apolipoprotein L1 (ApoL1) is a circulating innate immunity protein protecting against trypanosome infection. However, two ApoL1 coding variants are associated with a highly increased risk of chronic kidney disease. Here we present X-ray and NMR structures of the N-terminal domain (NTD) of ApoL1 and of its closest relative ApoL2. In both proteins, four of the five NTD helices form a four-helix core structure which is different from the classical four-helix bundle and from the pore-forming domain of colicin A. The reactivity with a conformation-specific antibody and structural models predict that this four-helix motif is also present in the NTDs of ApoL3 and ApoL4, suggesting related functions within the small ApoL family. The long helix 5 of ApoL1 is conformationally flexible and contains the BH3-like region. This BH3-like alpha-helix resembles true BH3 domains only in sequence and structure but not in function, since it does not bind to the pro-survival members of the Bcl-2 family, suggesting a Bcl-2-independent role in cytotoxicity. These findings should expedite a more comprehensive structural and functional understanding of the ApoL immune protein family.
		+
		+	Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif.,Ultsch M, Holliday MJ, Gerhardy S, Moran P, Scales SJ, Gupta N, Oltrabella F, Chiu C, Fairbrother W, Eigenbrot C, Kirchhofer D Commun Biol. 2021 Jul 27;4(1):916. doi: 10.1038/s42003-021-02387-5. PMID:34316015<ref>PMID:34316015</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7l6k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fairbrother WJ]]	+	[[Category: Fairbrother, W J]]
-	[[Category: Holliday MJ]]	+	[[Category: Holliday, M J]]
-	[[Category: Kirchhofer D]]	+	[[Category: Kirchhofer, D]]
-	[[Category: Moran P]]	+	[[Category: Moran, P]]
-	[[Category: Ultsch M]]	+	[[Category: Ultsch, M]]
		+	[[Category: Ion channel]]
		+	[[Category: Kidney disease]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Membrane protein]]

OCA at 10:19, 4 August 2021

OCA — Wed, 04 Aug 2021 10:19:26 GMT

←Older revision		Revision as of 10:19, 4 August 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7l6k is ~~ON HOLD until Paper Publication~~	+	==ApoL1 N-terminal domain==
-		+	<StructureSection load='7l6k' size='340' side='right'caption='[[7l6k]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L6K FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l6k OCA], [https://pdbe.org/7l6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l6k RCSB], [https://www.ebi.ac.uk/pdbsum/7l6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l6k ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fairbrother WJ]]
		+	[[Category: Holliday MJ]]
		+	[[Category: Kirchhofer D]]
		+	[[Category: Moran P]]
		+	[[Category: Ultsch M]]

OCA at 06:53, 20 January 2021

OCA — Wed, 20 Jan 2021 06:53:04 GMT

←Older revision		Revision as of 06:53, 20 January 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7l6k is ON HOLD	+	The entry 7l6k is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7l6k" [edit=sysop:move=sysop]

OCA — Wed, 30 Dec 2020 05:33:36 GMT

Protected "7l6k" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:33, 30 December 2020

OCA: New page: '''Unreleased structure''' The entry 7l6k is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 30 Dec 2020 05:33:35 GMT

New page: '''Unreleased structure''' The entry 7l6k is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7l6k is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]