7la5 - Revision history

OCA at 15:42, 18 October 2023

OCA — Wed, 18 Oct 2023 15:42:06 GMT

←Older revision		Revision as of 15:42, 18 October 2023
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-	====	+	==Structure of human GGT1 in complex with Lnt1-172 compound.==
-	<StructureSection load='7la5' size='340' side='right'caption='[[7la5]]' scene=''>	+	<StructureSection load='7la5' size='340' side='right'caption='[[7la5]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7la5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LA5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7la5 OCA], [https://pdbe.org/7la5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7la5 RCSB], [https://www.ebi.ac.uk/pdbsum/7la5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7la5 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.07Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=XSM:(2R)-4-borono-2-{[(1H-imidazol-4-yl)methyl]amino}butanoic+acid'>XSM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7la5 OCA], [https://pdbe.org/7la5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7la5 RCSB], [https://www.ebi.ac.uk/pdbsum/7la5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7la5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN] Gamma-glutamyl transpeptidase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN] Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.<ref>PMID:7689219</ref> <ref>PMID:20622017</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Hanigan M]]
		+	[[Category: Nguen L]]
		+	[[Category: Terzyan SS]]

OCA at 09:56, 12 January 2022

OCA — Wed, 12 Jan 2022 09:56:42 GMT

←Older revision		Revision as of 09:56, 12 January 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7la5 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7la5' size='340' side='right'caption='[[7la5]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7la5 OCA], [https://pdbe.org/7la5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7la5 RCSB], [https://www.ebi.ac.uk/pdbsum/7la5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7la5 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7la5" [edit=sysop:move=sysop]

OCA — Wed, 20 Jan 2021 06:53:20 GMT

Protected "7la5" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:53, 20 January 2021

OCA: New page: '''Unreleased structure''' The entry 7la5 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Jan 2021 06:53:19 GMT

New page: '''Unreleased structure''' The entry 7la5 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7la5 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]