OCA at 15:46, 18 October 2023

OCA — Wed, 18 Oct 2023 15:46:35 GMT

←Older revision		Revision as of 15:46, 18 October 2023
Line 1:		Line 1:

-	====	+	==Fab 7D6 bound to ApoL1 NTD==
-	<StructureSection load='7lfb' size='340' side='right'caption='[[7lfb]]' scene=''>	+	<StructureSection load='7lfb' size='340' side='right'caption='[[7lfb]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lfb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LFB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lfb OCA], [https://pdbe.org/7lfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lfb RCSB], [https://www.ebi.ac.uk/pdbsum/7lfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lfb ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.913Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lfb OCA], [https://pdbe.org/7lfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lfb RCSB], [https://www.ebi.ac.uk/pdbsum/7lfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lfb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN] Genetic steroid-resistant nephrotic syndrome. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN] May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Apolipoprotein L1 (ApoL1) is a circulating innate immunity protein protecting against trypanosome infection. However, two ApoL1 coding variants are associated with a highly increased risk of chronic kidney disease. Here we present X-ray and NMR structures of the N-terminal domain (NTD) of ApoL1 and of its closest relative ApoL2. In both proteins, four of the five NTD helices form a four-helix core structure which is different from the classical four-helix bundle and from the pore-forming domain of colicin A. The reactivity with a conformation-specific antibody and structural models predict that this four-helix motif is also present in the NTDs of ApoL3 and ApoL4, suggesting related functions within the small ApoL family. The long helix 5 of ApoL1 is conformationally flexible and contains the BH3-like region. This BH3-like alpha-helix resembles true BH3 domains only in sequence and structure but not in function, since it does not bind to the pro-survival members of the Bcl-2 family, suggesting a Bcl-2-independent role in cytotoxicity. These findings should expedite a more comprehensive structural and functional understanding of the ApoL immune protein family.
		+
		+	Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif.,Ultsch M, Holliday MJ, Gerhardy S, Moran P, Scales SJ, Gupta N, Oltrabella F, Chiu C, Fairbrother W, Eigenbrot C, Kirchhofer D Commun Biol. 2021 Jul 27;4(1):916. doi: 10.1038/s42003-021-02387-5. PMID:34316015<ref>PMID:34316015</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7lfb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Kirchhofer D]]
		+	[[Category: Ultsch M]]

OCA at 10:20, 4 August 2021

OCA — Wed, 04 Aug 2021 10:20:01 GMT

←Older revision		Revision as of 10:20, 4 August 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7lfb ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7lfb' size='340' side='right'caption='[[7lfb]]' scene=''>
-	~~Authors~~: ~~Ultsch, M~~.~~, Kirchhofer, D~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Fab 7D6 bound to ApoL1 NTD~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lfb OCA], [https://pdbe.org/7lfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lfb RCSB], [https://www.ebi.ac.uk/pdbsum/7lfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lfb ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Ultsch, M~~]]	+	__TOC__
-	[[Category: ~~Kirchhofer, D~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7lfb" [edit=sysop:move=sysop]

OCA — Wed, 27 Jan 2021 06:47:26 GMT

Protected "7lfb" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:47, 27 January 2021

OCA: New page: '''Unreleased structure''' The entry 7lfb is ON HOLD until Paper Publication Authors: Ultsch, M., Kirchhofer, D. Description: Fab 7D6 bound to ApoL1 NTD [[Category: Unreleased Structur...

OCA — Wed, 27 Jan 2021 06:47:25 GMT

New page: '''Unreleased structure''' The entry 7lfb is ON HOLD until Paper Publication Authors: Ultsch, M., Kirchhofer, D. Description: Fab 7D6 bound to ApoL1 NTD [[Category: Unreleased Structur...

New page

'''Unreleased structure'''

The entry 7lfb is ON HOLD until Paper Publication

Authors: Ultsch, M., Kirchhofer, D.

Description: Fab 7D6 bound to ApoL1 NTD
[[Category: Unreleased Structures]]
[[Category: Ultsch, M]]
[[Category: Kirchhofer, D]]

7lfb - Revision history

OCA at 15:46, 18 October 2023

OCA at 10:20, 4 August 2021

OCA: Protected "7lfb" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7lfb is ON HOLD until Paper Publication Authors: Ultsch, M., Kirchhofer, D. Description: Fab 7D6 bound to ApoL1 NTD [[Category: Unreleased Structur...