7lh8 - Revision history

OCA at 09:20, 25 October 2023

OCA — Wed, 25 Oct 2023 09:20:51 GMT

←Older revision		Revision as of 09:20, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7lh8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LH8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7lh8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LH8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XZG:(5R)-1-ethyl-5-(4-methylphenyl)-7-({1-[(4-nitrophenyl)methyl]piperidin-4-yl}methyl)-5,7,8,9-tetrahydro-1H-pyrrolo[3,4 5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione'>XZG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XZG:(5R)-1-ethyl-5-(4-methylphenyl)-7-({1-[(4-nitrophenyl)methyl]piperidin-4-yl}methyl)-5,7,8,9-tetrahydro-1H-pyrrolo[3,4 5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione'>XZG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lh8 OCA], [https://pdbe.org/7lh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lh8 RCSB], [https://www.ebi.ac.uk/pdbsum/7lh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lh8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lh8 OCA], [https://pdbe.org/7lh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lh8 RCSB], [https://www.ebi.ac.uk/pdbsum/7lh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lh8 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:04, 1 February 2023

OCA — Wed, 01 Feb 2023 12:04:41 GMT

←Older revision		Revision as of 12:04, 1 February 2023
Line 8:		Line 8:
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:38, 8 September 2022

OCA — Thu, 08 Sep 2022 06:38:33 GMT

←Older revision		Revision as of 06:38, 8 September 2022
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	==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR JJ-II-131==		==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR JJ-II-131==
-	<StructureSection load='7lh8' size='340' side='right'caption='[[7lh8]]' scene=''>	+	<StructureSection load='7lh8' size='340' side='right'caption='[[7lh8]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LH8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lh8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LH8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lh8 OCA], [https://pdbe.org/7lh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lh8 RCSB], [https://www.ebi.ac.uk/pdbsum/7lh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lh8 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XZG:(5R)-1-ethyl-5-(4-methylphenyl)-7-({1-[(4-nitrophenyl)methyl]piperidin-4-yl}methyl)-5,7,8,9-tetrahydro-1H-pyrrolo[3,4 5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione'>XZG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lh8 OCA], [https://pdbe.org/7lh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lh8 RCSB], [https://www.ebi.ac.uk/pdbsum/7lh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lh8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chan A]]		[[Category: Chan A]]
	[[Category: Schonbrunn E]]		[[Category: Schonbrunn E]]

OCA at 16:11, 6 July 2022

OCA — Wed, 06 Jul 2022 16:11:28 GMT

←Older revision		Revision as of 16:11, 6 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7lh8 is ON HOLD until Paper Publication~~	+	==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR JJ-II-131==
-		+	<StructureSection load='7lh8' size='340' side='right'caption='[[7lh8]]' scene=''>
-	~~Authors: Schonbrunn, E., Chan, A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LH8 FirstGlance]. <br>
-	~~Description:~~ CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR JJ-II-131	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lh8 OCA], [https://pdbe.org/7lh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lh8 RCSB], [https://www.ebi.ac.uk/pdbsum/7lh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lh8 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Schonbrunn~~, E]]	+	__TOC__
-	[[Category: Chan, A]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chan A]]
		+	[[Category: Schonbrunn E]]

OCA at 09:28, 3 February 2021

OCA — Wed, 03 Feb 2021 09:28:11 GMT

←Older revision		Revision as of 09:28, 3 February 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7lh8 is ON HOLD	+	The entry 7lh8 is ON HOLD until Paper Publication

	Authors: Schonbrunn, E., Chan, A.		Authors: Schonbrunn, E., Chan, A.

OCA: Protected "7lh8" [edit=sysop:move=sysop]

OCA — Wed, 27 Jan 2021 06:50:27 GMT

Protected "7lh8" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:50, 27 January 2021

OCA: New page: '''Unreleased structure''' The entry 7lh8 is ON HOLD Authors: Schonbrunn, E., Chan, A. Description: CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR J...

OCA — Wed, 27 Jan 2021 06:50:26 GMT

New page: '''Unreleased structure''' The entry 7lh8 is ON HOLD Authors: Schonbrunn, E., Chan, A. Description: CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR J...

New page

'''Unreleased structure'''

The entry 7lh8 is ON HOLD

Authors: Schonbrunn, E., Chan, A.

Description: CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR JJ-II-131
[[Category: Unreleased Structures]]
[[Category: Schonbrunn, E]]
[[Category: Chan, A]]