OCA at 15:50, 18 October 2023

OCA — Wed, 18 Oct 2023 15:50:26 GMT

←Older revision		Revision as of 15:50, 18 October 2023
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-	====	+	==Human Prx1-Srx Decameric Complex==
-	<StructureSection load='7lj1' size='340' side='right'caption='[[7lj1]]' scene=''>	+	<StructureSection load='7lj1' size='340' side='right'caption='[[7lj1]], [[Resolution\|resolution]] 2.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lj1]] is a 40 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LJ1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lj1 OCA], [https://pdbe.org/7lj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lj1 RCSB], [https://www.ebi.ac.uk/pdbsum/7lj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lj1 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.97Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lj1 OCA], [https://pdbe.org/7lj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lj1 RCSB], [https://www.ebi.ac.uk/pdbsum/7lj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lj1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PRDX1_HUMAN PRDX1_HUMAN] Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human peroxiredoxins (Prx) are a family of antioxidant enzymes involved in a myriad of cellular functions and diseases. During the reaction with peroxides (e.g., H(2)O(2)), the typical 2-Cys Prxs change oligomeric structure between higher order (do)decamers and disulfide-linked dimers, with the hyperoxidized inactive state (-SO(2)H) favoring the multimeric structure of the reduced enzyme. Here, we present a study on the structural requirements for the repair of hyperoxidized 2-Cys Prxs by human sulfiredoxin (Srx) and the relative efficacy of physiological reductants hydrogen sulfide (H(2)S) and glutathione (GSH) in this reaction. The crystal structure of the toroidal Prx1-Srx complex shows an extended active site interface. The loss of this interface within engineered Prx2 and Prx3 dimers yielded variants more resistant to hyperoxidation and repair by Srx. Finally, we reveal for the first time Prx isoform-dependent use of and potential cooperation between GSH and H(2)S in supporting Srx activity.
		+
		+	Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State.,Forshaw TE, Reisz JA, Nelson KJ, Gumpena R, Lawson JR, Jonsson TJ, Wu H, Clodfelter JE, Johnson LC, Furdui CM, Lowther WT Antioxidants (Basel). 2021 Jun 11;10(6):946. doi: 10.3390/antiox10060946. PMID:34208049<ref>PMID:34208049</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7lj1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Peroxiredoxin 3D structures\|Peroxiredoxin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Clodfelter JE]]
		+	[[Category: Forshaw TE]]
		+	[[Category: Furdui CM]]
		+	[[Category: Gumpena R]]
		+	[[Category: Johnson L]]
		+	[[Category: Jonsson T]]
		+	[[Category: Lawson JR]]
		+	[[Category: Lowther WT]]
		+	[[Category: Nelson KJ]]
		+	[[Category: Reisz JA]]
		+	[[Category: Wu H]]

OCA at 09:54, 14 July 2021

OCA — Wed, 14 Jul 2021 09:54:38 GMT

←Older revision		Revision as of 09:54, 14 July 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7lj1 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7lj1' size='340' side='right'caption='[[7lj1]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lj1 OCA], [https://pdbe.org/7lj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lj1 RCSB], [https://www.ebi.ac.uk/pdbsum/7lj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lj1 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 09:16, 10 February 2021

OCA — Wed, 10 Feb 2021 09:16:37 GMT

←Older revision		Revision as of 09:16, 10 February 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7lj1 is ON HOLD	+	The entry 7lj1 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7lj1" [edit=sysop:move=sysop]

OCA — Wed, 03 Feb 2021 09:32:34 GMT

Protected "7lj1" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:32, 3 February 2021

OCA: New page: '''Unreleased structure''' The entry 7lj1 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Feb 2021 09:32:33 GMT

New page: '''Unreleased structure''' The entry 7lj1 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7lj1 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7lj1 - Revision history

OCA at 15:50, 18 October 2023

OCA at 09:54, 14 July 2021

OCA at 09:16, 10 February 2021

OCA: Protected "7lj1" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7lj1 is ON HOLD Authors: Description: Category: Unreleased Structures