7ljr - Revision history

OCA at 14:59, 6 March 2024

OCA — Wed, 06 Mar 2024 14:59:42 GMT

←Older revision		Revision as of 14:59, 6 March 2024
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-	====	+	==SARS-CoV-2 Spike Protein Trimer bound to DH1043 fab==
-	<StructureSection load='7ljr' size='340' side='right'caption='[[7ljr]]' scene=''>	+	<StructureSection load='7ljr' size='340' side='right'caption='[[7ljr]], [[Resolution\|resolution]] 3.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ljr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LJR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ljr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ljr OCA], [https://pdbe.org/7ljr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ljr RCSB], [https://www.ebi.ac.uk/pdbsum/7ljr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ljr ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.66Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ljr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ljr OCA], [https://pdbe.org/7ljr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ljr RCSB], [https://www.ebi.ac.uk/pdbsum/7ljr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ljr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Spike protein 3D structures\|Spike protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Acharya P]]
		+	[[Category: Gobeil S]]

OCA at 10:33, 31 March 2021

OCA — Wed, 31 Mar 2021 10:33:58 GMT

←Older revision		Revision as of 10:33, 31 March 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7ljr ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7ljr' size='340' side='right'caption='[[7ljr]]' scene=''>
-	~~Authors~~: ~~Gobeil, S~~.~~, Acharya, P~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~SARS-CoV~~-~~2 Spike Protein Trimer bound to DH1043 fab~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ljr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ljr OCA], [https://pdbe.org/7ljr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ljr RCSB], [https://www.ebi.ac.uk/pdbsum/7ljr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ljr ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Acharya, P~~]]	+	__TOC__
-	[[Category: ~~Gobeil, S~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 14:39, 10 March 2021

OCA — Wed, 10 Mar 2021 14:39:22 GMT

←Older revision		Revision as of 14:39, 10 March 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ljr is ON HOLD	+	The entry 7ljr is ON HOLD until Paper Publication

	Authors: Gobeil, S., Acharya, P.		Authors: Gobeil, S., Acharya, P.

OCA: Protected "7ljr" [edit=sysop:move=sysop]

OCA — Wed, 10 Feb 2021 09:17:53 GMT

Protected "7ljr" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:17, 10 February 2021

OCA: New page: '''Unreleased structure''' The entry 7ljr is ON HOLD Authors: Gobeil, S., Acharya, P. Description: SARS-CoV-2 Spike Protein Trimer bound to DH1043 fab [[Category: Unreleased Structures...

OCA — Wed, 10 Feb 2021 09:17:52 GMT

New page: '''Unreleased structure''' The entry 7ljr is ON HOLD Authors: Gobeil, S., Acharya, P. Description: SARS-CoV-2 Spike Protein Trimer bound to DH1043 fab [[Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 7ljr is ON HOLD

Authors: Gobeil, S., Acharya, P.

Description: SARS-CoV-2 Spike Protein Trimer bound to DH1043 fab
[[Category: Unreleased Structures]]
[[Category: Acharya, P]]
[[Category: Gobeil, S]]