7lk9 - Revision history

OCA at 15:52, 18 October 2023

OCA — Wed, 18 Oct 2023 15:52:38 GMT

←Older revision		Revision as of 15:52, 18 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7lk9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LK9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7lk9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LK9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lk9 OCA], [https://pdbe.org/7lk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lk9 RCSB], [https://www.ebi.ac.uk/pdbsum/7lk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lk9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lk9 OCA], [https://pdbe.org/7lk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lk9 RCSB], [https://www.ebi.ac.uk/pdbsum/7lk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lk9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:43, 9 November 2022

OCA — Wed, 09 Nov 2022 07:43:02 GMT

←Older revision		Revision as of 07:43, 9 November 2022
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-	====	+	==Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HC + COVD21-C8 LC==
-	<StructureSection load='7lk9' size='340' side='right'caption='[[7lk9]]' scene=''>	+	<StructureSection load='7lk9' size='340' side='right'caption='[[7lk9]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lk9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LK9 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lk9 OCA], [https://pdbe.org/7lk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lk9 RCSB], [https://www.ebi.ac.uk/pdbsum/7lk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lk9 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lk9 OCA], [https://pdbe.org/7lk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lk9 RCSB], [https://www.ebi.ac.uk/pdbsum/7lk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lk9 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Since the COVID-19 pandemic onset, the antibody response to SARS-CoV-2 has been extensively characterized. Antibodies to the receptor binding domain (RBD) on the spike protein are frequently encoded by IGHV3-53/3-66 with a short complementarity-determining region (CDR) H3. Germline-encoded sequence motifs in heavy chain CDRs H1 and H2 have a major function, but whether any common motifs are present in CDR H3, which is often critical for binding specificity, is not clear. Here, we identify two public clonotypes of IGHV3-53/3-66 RBD antibodies with a 9-residue CDR H3 that pair with different light chains. Distinct sequence motifs on CDR H3 are present in the two public clonotypes that seem to be related to differential light chain pairing. Additionally, we show that Y58F is a common somatic hypermutation that results in increased binding affinity of IGHV3-53/3-66 RBD antibodies with a short CDR H3. These results advance understanding of the antibody response to SARS-CoV-2.
		+
		+	Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain.,Tan TJC, Yuan M, Kuzelka K, Padron GC, Beal JR, Chen X, Wang Y, Rivera-Cardona J, Zhu X, Stadtmueller BM, Brooke CB, Wilson IA, Wu NC Nat Commun. 2021 Jun 21;12(1):3815. doi: 10.1038/s41467-021-24123-7. PMID:34155209<ref>PMID:34155209</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7lk9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Wilson IA]]
		+	[[Category: Wu NC]]
		+	[[Category: Yuan M]]
		+	[[Category: Zhu X]]

OCA at 10:02, 17 February 2021

OCA — Wed, 17 Feb 2021 10:02:44 GMT

←Older revision		Revision as of 10:02, 17 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7lk9 ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7lk9' size='340' side='right'caption='[[7lk9]]' scene=''>
-	~~Authors~~: ~~Yuan, M~~.~~, Zhu, X~~.~~, Wilson, I~~.A.~~, Wu, N~~.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HC + COVD21-C8 LC~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lk9 OCA], [https://pdbe.org/7lk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lk9 RCSB], [https://www.ebi.ac.uk/pdbsum/7lk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lk9 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Wilson~~, I.A]]	+	__TOC__
-	[~~[Category~~: ~~Zhu~~, X]]	+	</StructureSection>
-	[[Category: ~~Wu, N.C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Yuan, M~~]]	+	[[Category: Z-disk]]

OCA: Protected "7lk9" [edit=sysop:move=sysop]

OCA — Wed, 10 Feb 2021 09:19:10 GMT

Protected "7lk9" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:19, 10 February 2021

OCA: New page: '''Unreleased structure''' The entry 7lk9 is ON HOLD Authors: Yuan, M., Zhu, X., Wilson, I.A., Wu, N.C. Description: Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HC...

OCA — Wed, 10 Feb 2021 09:19:08 GMT

New page: '''Unreleased structure''' The entry 7lk9 is ON HOLD Authors: Yuan, M., Zhu, X., Wilson, I.A., Wu, N.C. Description: Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HC...

New page

'''Unreleased structure'''

The entry 7lk9 is ON HOLD

Authors: Yuan, M., Zhu, X., Wilson, I.A., Wu, N.C.

Description: Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HC + COVD21-C8 LC
[[Category: Unreleased Structures]]
[[Category: Wilson, I.A]]
[[Category: Zhu, X]]
[[Category: Wu, N.C]]
[[Category: Yuan, M]]