7lqg - Revision history

OCA at 11:00, 15 November 2023

OCA — Wed, 15 Nov 2023 11:00:29 GMT

←Older revision		Revision as of 11:00, 15 November 2023
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	<StructureSection load='7lqg' size='340' side='right'caption='[[7lqg]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='7lqg' size='340' side='right'caption='[[7lqg]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7lqg]] is a 144 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lqg]] is a 144 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LQG FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CR:N-ACETYL-L-PHENYLALANINE'>5CR</scene>, <scene name='pdbligand=GMA:4-AMIDO-4-CARBAMOYL-BUTYRIC+ACID'>GMA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CR:N-ACETYL-L-PHENYLALANINE'>5CR</scene>, <scene name='pdbligand=GMA:4-AMIDO-4-CARBAMOYL-BUTYRIC+ACID'>GMA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqg OCA], [https://pdbe.org/7lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqg RCSB], [https://www.ebi.ac.uk/pdbsum/7lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqg OCA], [https://pdbe.org/7lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqg RCSB], [https://www.ebi.ac.uk/pdbsum/7lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqg ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Conticello, V P~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Egelman, E H~~]]	+	[[Category: Conticello VP]]
-	[[Category: ~~Gnewou, O M~~]]	+	[[Category: Egelman EH]]
-	[[Category: ~~Wang, F~~]]	+	[[Category: Gnewou OM]]
-	[[Category: ~~Cryo-em]]~~	+	[[Category: Wang F]]
-	~~[[Category: Filament]]~~	+
-	~~[[Category: Nanotube]]~~	+
-	~~[[Category: Peptide fibril]]~~	+
-	~~[[Category: Protein fibril]]~~	+
-	~~[[Category: Self-assembly peptide filament~~]]	+

OCA at 15:51, 27 October 2021

OCA — Wed, 27 Oct 2021 15:51:20 GMT

←Older revision		Revision as of 15:51, 27 October 2021
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqg OCA], [https://pdbe.org/7lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqg RCSB], [https://www.ebi.ac.uk/pdbsum/7lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqg OCA], [https://pdbe.org/7lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqg RCSB], [https://www.ebi.ac.uk/pdbsum/7lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqg ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The self-assembly of designed peptides into filaments and other higher-order structures has been the focus of intense interest because of the potential for creating new biomaterials and biomedical devices. These peptide assemblies have also been used as models for understanding biological processes, such as the pathological formation of amyloid. We investigate the assembly of an octapeptide sequence, Ac-FKFEFKFE-NH2, motivated by prior studies that demonstrated that this amphipathic beta strand peptide self-assembled into fibrils and biocompatible hydrogels. Using high-resolution cryoelectron microscopy (cryo-EM), we are able to determine the atomic structure for two different coexisting forms of the fibrils, containing four and five beta sandwich protofilaments, respectively. Surprisingly, the inner walls in both forms are parallel beta sheets, while the outer walls are antiparallel beta sheets. Our results demonstrate the chaotic nature of peptide self-assembly and illustrate the importance of cryo-EM structural analysis to understand the complex phase behavior of these materials at near-atomic resolution.
		+
		+	Deterministic chaos in the self-assembly of beta sheet nanotubes from an amphipathic oligopeptide.,Wang F, Gnewou O, Wang S, Osinski T, Zuo X, Egelman EH, Conticello VP Matter. 2021 Oct 6;4(10):3217-3231. doi: 10.1016/j.matt.2021.06.037. Epub 2021, Jul 27. PMID:34632372<ref>PMID:34632372</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7lqg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:17, 11 August 2021

OCA — Wed, 11 Aug 2021 06:17:32 GMT

←Older revision		Revision as of 06:17, 11 August 2021
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	==Cryo-EM of the KFE8 thinner nanotube (class 1, C2)==		==Cryo-EM of the KFE8 thinner nanotube (class 1, C2)==
-	<StructureSection load='7lqg' size='340' side='right'caption='[[7lqg]]' scene=''>	+	<StructureSection load='7lqg' size='340' side='right'caption='[[7lqg]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lqg]] is a 144 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LQG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqg OCA], [https://pdbe.org/7lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqg RCSB], [https://www.ebi.ac.uk/pdbsum/7lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqg ProSAT]</span></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CR:N-ACETYL-L-PHENYLALANINE'>5CR</scene>, <scene name='pdbligand=GMA:4-AMIDO-4-CARBAMOYL-BUTYRIC+ACID'>GMA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqg OCA], [https://pdbe.org/7lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqg RCSB], [https://www.ebi.ac.uk/pdbsum/7lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqg ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Conticello VP]]	+	[[Category: Conticello, V P]]
-	[[Category: Egelman EH]]	+	[[Category: Egelman, E H]]
-	[[Category: Gnewou OM]]	+	[[Category: Gnewou, O M]]
-	[[Category: Wang F]]	+	[[Category: Wang, F]]
		+	[[Category: Cryo-em]]
		+	[[Category: Filament]]
		+	[[Category: Nanotube]]
		+	[[Category: Peptide fibril]]
		+	[[Category: Protein fibril]]
		+	[[Category: Self-assembly peptide filament]]

OCA at 03:34, 2 July 2021

OCA — Fri, 02 Jul 2021 03:34:13 GMT

←Older revision		Revision as of 03:34, 2 July 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7lqg ~~is ON HOLD until Paper Publication~~	+	==Cryo-EM of the KFE8 thinner nanotube (class 1, C2)==
-		+	<StructureSection load='7lqg' size='340' side='right'caption='[[7lqg]]' scene=''>
-	~~Authors~~: ~~Wang~~, F., ~~Gnewou~~, O.M., ~~Egelman, E~~.H., ~~Conticello, V~~.P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LQG FirstGlance]. <br>
-	~~Description: Cryo-EM of the KFE8 thinner nanotube (class 1, C2)~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqg OCA], [https://pdbe.org/7lqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqg RCSB], [https://www.ebi.ac.uk/pdbsum/7lqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqg ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Egelman, E.H~~]]	+	__TOC__
-	[[Category: ~~Wang, F~~]]	+	</StructureSection>
-	[[Category: ~~Conticello, V.P~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Gnewou, O.M~~]]	+	[[Category: Conticello VP]]
		+	[[Category: Egelman EH]]
		+	[[Category: Gnewou OM]]
		+	[[Category: Wang F]]

OCA at 05:23, 17 March 2021

OCA — Wed, 17 Mar 2021 05:23:04 GMT

←Older revision		Revision as of 05:23, 17 March 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7lqg is ON HOLD	+	The entry 7lqg is ON HOLD until Paper Publication

	Authors: Wang, F., Gnewou, O.M., Egelman, E.H., Conticello, V.P.		Authors: Wang, F., Gnewou, O.M., Egelman, E.H., Conticello, V.P.
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	Description: Cryo-EM of the KFE8 thinner nanotube (class 1, C2)		Description: Cryo-EM of the KFE8 thinner nanotube (class 1, C2)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Conticello, V.P]]
-	[[Category: Gnewou, O.M]]
	[[Category: Egelman, E.H]]		[[Category: Egelman, E.H]]
	[[Category: Wang, F]]		[[Category: Wang, F]]
		+	[[Category: Conticello, V.P]]
		+	[[Category: Gnewou, O.M]]

OCA: Protected "7lqg" [edit=sysop:move=sysop]

OCA — Wed, 24 Feb 2021 05:40:34 GMT

Protected "7lqg" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:40, 24 February 2021

OCA: New page: '''Unreleased structure''' The entry 7lqg is ON HOLD Authors: Wang, F., Gnewou, O.M., Egelman, E.H., Conticello, V.P. Description: Cryo-EM of the KFE8 thinner nanotube (class 1, C2) [[...

OCA — Wed, 24 Feb 2021 05:40:33 GMT

New page: '''Unreleased structure''' The entry 7lqg is ON HOLD Authors: Wang, F., Gnewou, O.M., Egelman, E.H., Conticello, V.P. Description: Cryo-EM of the KFE8 thinner nanotube (class 1, C2) [[...

New page

'''Unreleased structure'''

The entry 7lqg is ON HOLD

Authors: Wang, F., Gnewou, O.M., Egelman, E.H., Conticello, V.P.

Description: Cryo-EM of the KFE8 thinner nanotube (class 1, C2)
[[Category: Unreleased Structures]]
[[Category: Conticello, V.P]]
[[Category: Gnewou, O.M]]
[[Category: Egelman, E.H]]
[[Category: Wang, F]]