7lwg - Revision history

OCA at 09:21, 25 October 2023

OCA — Wed, 25 Oct 2023 09:21:16 GMT

←Older revision		Revision as of 09:21, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7lwg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LWG FirstGlance]. <br>		<table><tr><td colspan='2'>[[7lwg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LWG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=YN7:5-{(5S)-1-[2-({3-chloro-6-[(2S)-2,4-dimethylpiperazin-1-yl]-2-fluoropyridin-4-yl}amino)-2-oxoethyl]-4-oxo-4,6,7,8-tetrahydro-1H-dipyrrolo[1,2-a 2,3-d]pyrimidin-3-yl}-3,4-difluoro-2-hydroxybenzamide'>YN7</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=YN7:5-{(5S)-1-[2-({3-chloro-6-[(2S)-2,4-dimethylpiperazin-1-yl]-2-fluoropyridin-4-yl}amino)-2-oxoethyl]-4-oxo-4,6,7,8-tetrahydro-1H-dipyrrolo[1,2-a 2,3-d]pyrimidin-3-yl}-3,4-difluoro-2-hydroxybenzamide'>YN7</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lwg OCA], [https://pdbe.org/7lwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lwg RCSB], [https://www.ebi.ac.uk/pdbsum/7lwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lwg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lwg OCA], [https://pdbe.org/7lwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lwg RCSB], [https://www.ebi.ac.uk/pdbsum/7lwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lwg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:53, 25 January 2023

OCA — Wed, 25 Jan 2023 06:53:15 GMT

←Older revision		Revision as of 06:53, 25 January 2023
Line 1:		Line 1:

	==Crystal structure of the BCL6 BTB domain in complex with OICR-12694==		==Crystal structure of the BCL6 BTB domain in complex with OICR-12694==
-	<StructureSection load='7lwg' size='340' side='right'caption='[[7lwg]]' scene=''>	+	<StructureSection load='7lwg' size='340' side='right'caption='[[7lwg]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LWG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lwg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LWG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lwg OCA], [https://pdbe.org/7lwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lwg RCSB], [https://www.ebi.ac.uk/pdbsum/7lwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lwg ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=YN7:5-{(5S)-1-[2-({3-chloro-6-[(2S)-2,4-dimethylpiperazin-1-yl]-2-fluoropyridin-4-yl}amino)-2-oxoethyl]-4-oxo-4,6,7,8-tetrahydro-1H-dipyrrolo[1,2-a 2,3-d]pyrimidin-3-yl}-3,4-difluoro-2-hydroxybenzamide'>YN7</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lwg OCA], [https://pdbe.org/7lwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lwg RCSB], [https://www.ebi.ac.uk/pdbsum/7lwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lwg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kuntz DA]]		[[Category: Kuntz DA]]
	[[Category: Prive GG]]		[[Category: Prive GG]]

OCA at 06:05, 9 March 2022

OCA — Wed, 09 Mar 2022 06:05:32 GMT

←Older revision		Revision as of 06:05, 9 March 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7lwg is ON HOLD until Paper Publication~~	+	==Crystal structure of the BCL6 BTB domain in complex with OICR-12694==
-		+	<StructureSection load='7lwg' size='340' side='right'caption='[[7lwg]]' scene=''>
-	~~Authors: Kuntz, D.A., Prive, G.G.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LWG FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the BCL6 BTB domain in complex with OICR-12694	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lwg OCA], [https://pdbe.org/7lwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lwg RCSB], [https://www.ebi.ac.uk/pdbsum/7lwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lwg ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Prive~~, G.G]]	+	__TOC__
-	[[Category: Kuntz~~, D.A~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kuntz DA]]
		+	[[Category: Prive GG]]

OCA at 05:30, 24 March 2021

OCA — Wed, 24 Mar 2021 05:30:22 GMT

←Older revision		Revision as of 05:30, 24 March 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7lwg is ON HOLD	+	The entry 7lwg is ON HOLD until Paper Publication

	Authors: Kuntz, D.A., Prive, G.G.		Authors: Kuntz, D.A., Prive, G.G.

OCA: Protected "7lwg" [edit=sysop:move=sysop]

OCA — Wed, 10 Mar 2021 14:46:23 GMT

Protected "7lwg" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:46, 10 March 2021

OCA: New page: '''Unreleased structure''' The entry 7lwg is ON HOLD Authors: Kuntz, D.A., Prive, G.G. Description: Crystal structure of the BCL6 BTB domain in complex with OICR-12694 [[Category: Unre...

OCA — Wed, 10 Mar 2021 14:46:21 GMT

New page: '''Unreleased structure''' The entry 7lwg is ON HOLD Authors: Kuntz, D.A., Prive, G.G. Description: Crystal structure of the BCL6 BTB domain in complex with OICR-12694 [[Category: Unre...

New page

'''Unreleased structure'''

The entry 7lwg is ON HOLD

Authors: Kuntz, D.A., Prive, G.G.

Description: Crystal structure of the BCL6 BTB domain in complex with OICR-12694
[[Category: Unreleased Structures]]
[[Category: Prive, G.G]]
[[Category: Kuntz, D.A]]