OCA at 16:01, 18 October 2023

OCA — Wed, 18 Oct 2023 16:01:26 GMT

←Older revision		Revision as of 16:01, 18 October 2023
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-	====	+	==Crystal structure of the HCMV pentamer-specific antibody 2-25==
-	<StructureSection load='7lyw' size='340' side='right'caption='[[7lyw]]' scene=''>	+	<StructureSection load='7lyw' size='340' side='right'caption='[[7lyw]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lyw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LYW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyw OCA], [https://pdbe.org/7lyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyw RCSB], [https://www.ebi.ac.uk/pdbsum/7lyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyw OCA], [https://pdbe.org/7lyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyw RCSB], [https://www.ebi.ac.uk/pdbsum/7lyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyw ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human cytomegalovirus (HCMV) encodes multiple surface glycoprotein complexes to infect a variety of cell types. The HCMV Pentamer, composed of gH, gL, UL128, UL130, and UL131A, enhances entry into epithelial, endothelial, and myeloid cells by interacting with the cell surface receptor neuropilin 2 (NRP2). Despite the critical nature of this interaction, the molecular determinants that govern NRP2 recognition remain unclear. Here, we describe the cryo-EM structure of NRP2 bound to Pentamer. The high-affinity interaction between these proteins is calcium dependent and differs from the canonical carboxyl-terminal arginine (CendR) binding that NRP2 typically uses. We also determine the structures of four neutralizing human antibodies bound to the HCMV Pentamer to define susceptible epitopes. Two of these antibodies compete with NRP2 binding, but the two most potent antibodies recognize a previously unidentified epitope that does not overlap the NRP2-binding site. Collectively, these findings provide a structural basis for HCMV tropism and antibody-mediated neutralization.
		+
		+	Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies.,Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS Sci Adv. 2022 Mar 11;8(10):eabm2546. doi: 10.1126/sciadv.abm2546. Epub 2022 Mar , 11. PMID:35275718<ref>PMID:35275718</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7lyw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: McLellan JS]]
		+	[[Category: Mishra AK]]
		+	[[Category: Wrapp D]]

OCA at 06:07, 11 August 2021

OCA — Wed, 11 Aug 2021 06:07:39 GMT

←Older revision		Revision as of 06:07, 11 August 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7lyw ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7lyw' size='340' side='right'caption='[[7lyw]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyw OCA], [https://pdbe.org/7lyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyw RCSB], [https://www.ebi.ac.uk/pdbsum/7lyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 06:11, 21 April 2021

OCA — Wed, 21 Apr 2021 06:11:57 GMT

←Older revision		Revision as of 06:11, 21 April 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7lyw is ON HOLD	+	The entry 7lyw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7lyw" [edit=sysop:move=sysop]

OCA — Wed, 17 Mar 2021 05:25:20 GMT

Protected "7lyw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:25, 17 March 2021

OCA: New page: '''Unreleased structure''' The entry 7lyw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 17 Mar 2021 05:25:18 GMT

New page: '''Unreleased structure''' The entry 7lyw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7lyw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7lyw - Revision history

OCA at 16:01, 18 October 2023

OCA at 06:07, 11 August 2021

OCA at 06:11, 21 April 2021

OCA: Protected "7lyw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7lyw is ON HOLD Authors: Description: Category: Unreleased Structures