7lzs - Revision history

OCA at 09:21, 25 October 2023

OCA — Wed, 25 Oct 2023 09:21:21 GMT

←Older revision		Revision as of 09:21, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7lzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LZS FirstGlance]. <br>		<table><tr><td colspan='2'>[[7lzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LZS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YJS:3-chloro-5-{7-[2-({5-chloro-2-[(3S)-3-methylmorpholin-4-yl]pyridin-4-yl}amino)-2-oxoethyl]-3-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-hydroxybenzamide'>YJS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.49Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YJS:3-chloro-5-{7-[2-({5-chloro-2-[(3S)-3-methylmorpholin-4-yl]pyridin-4-yl}amino)-2-oxoethyl]-3-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-hydroxybenzamide'>YJS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lzs OCA], [https://pdbe.org/7lzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lzs RCSB], [https://www.ebi.ac.uk/pdbsum/7lzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lzs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lzs OCA], [https://pdbe.org/7lzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lzs RCSB], [https://www.ebi.ac.uk/pdbsum/7lzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lzs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:53, 25 January 2023

OCA — Wed, 25 Jan 2023 06:53:21 GMT

←Older revision		Revision as of 06:53, 25 January 2023
Line 1:		Line 1:

	==Crystal structure of the BCL6 BTB domain in complex with OICR-11029==		==Crystal structure of the BCL6 BTB domain in complex with OICR-11029==
-	<StructureSection load='7lzs' size='340' side='right'caption='[[7lzs]]' scene=''>	+	<StructureSection load='7lzs' size='340' side='right'caption='[[7lzs]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LZS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LZS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lzs OCA], [https://pdbe.org/7lzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lzs RCSB], [https://www.ebi.ac.uk/pdbsum/7lzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lzs ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YJS:3-chloro-5-{7-[2-({5-chloro-2-[(3S)-3-methylmorpholin-4-yl]pyridin-4-yl}amino)-2-oxoethyl]-3-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-hydroxybenzamide'>YJS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lzs OCA], [https://pdbe.org/7lzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lzs RCSB], [https://www.ebi.ac.uk/pdbsum/7lzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lzs ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kuntz DA]]		[[Category: Kuntz DA]]
	[[Category: Prive GG]]		[[Category: Prive GG]]

OCA at 06:13, 16 March 2022

OCA — Wed, 16 Mar 2022 06:13:31 GMT

←Older revision		Revision as of 06:13, 16 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7lzs ~~is ON HOLD~~	+	==Crystal structure of the BCL6 BTB domain in complex with OICR-11029==
-		+	<StructureSection load='7lzs' size='340' side='right'caption='[[7lzs]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LZS FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lzs OCA], [https://pdbe.org/7lzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lzs RCSB], [https://www.ebi.ac.uk/pdbsum/7lzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lzs ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kuntz DA]]
		+	[[Category: Prive GG]]

OCA: Protected "7lzs" [edit=sysop:move=sysop]

OCA — Wed, 17 Mar 2021 05:26:54 GMT

Protected "7lzs" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:26, 17 March 2021

OCA: New page: '''Unreleased structure''' The entry 7lzs is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 17 Mar 2021 05:26:53 GMT

New page: '''Unreleased structure''' The entry 7lzs is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7lzs is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]