7m56 - Revision history

OCA at 16:05, 18 October 2023

OCA — Wed, 18 Oct 2023 16:05:44 GMT

←Older revision		Revision as of 16:05, 18 October 2023
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	==Structure of human endothelial nitric oxide synthase heme domain in complex with 7-((3-(3-aminophenethyl)phenoxy)methyl)quinolin-2-amine==		==Structure of human endothelial nitric oxide synthase heme domain in complex with 7-((3-(3-aminophenethyl)phenoxy)methyl)quinolin-2-amine==
-	<StructureSection load='7m56' size='340' side='right'caption='[[7m56]]' scene=''>	+	<StructureSection load='7m56' size='340' side='right'caption='[[7m56]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M56 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7m56]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M56 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m56 OCA], [https://pdbe.org/7m56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m56 RCSB], [https://www.ebi.ac.uk/pdbsum/7m56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m56 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.957Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=V5G:7-({3-[2-(6-aminopyridin-2-yl)ethyl]phenoxy}methyl)quinolin-2-amine'>V5G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m56 OCA], [https://pdbe.org/7m56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m56 RCSB], [https://www.ebi.ac.uk/pdbsum/7m56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m56 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref> Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref>
		+
		+	==See Also==
		+	*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li H]]		[[Category: Li H]]
	[[Category: Poulos TL]]		[[Category: Poulos TL]]

OCA at 10:44, 30 March 2022

OCA — Wed, 30 Mar 2022 10:44:47 GMT

←Older revision		Revision as of 10:44, 30 March 2022
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-	'''Unreleased structure'''

-	~~The entry 7m56 is ON HOLD until Paper Publication~~	+	==Structure of human endothelial nitric oxide synthase heme domain in complex with 7-((3-(3-aminophenethyl)phenoxy)methyl)quinolin-2-amine==
-		+	<StructureSection load='7m56' size='340' side='right'caption='[[7m56]]' scene=''>
-	~~Authors: Li, H., Poulos, T.L.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M56 FirstGlance]. <br>
-	~~Description:~~ Structure of human endothelial nitric oxide synthase heme domain in complex with 7-((3-(3-aminophenethyl)phenoxy)methyl)quinolin-2-amine	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m56 OCA], [https://pdbe.org/7m56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m56 RCSB], [https://www.ebi.ac.uk/pdbsum/7m56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m56 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Li, H]]	+	__TOC__
-	[[Category: Poulos~~, T.L~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Li H]]
		+	[[Category: Poulos TL]]

OCA at 04:36, 7 April 2021

OCA — Wed, 07 Apr 2021 04:36:02 GMT

←Older revision		Revision as of 04:36, 7 April 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7m56 is ON HOLD	+	The entry 7m56 is ON HOLD until Paper Publication

	Authors: Li, H., Poulos, T.L.		Authors: Li, H., Poulos, T.L.

OCA: Protected "7m56" [edit=sysop:move=sysop]

OCA — Wed, 31 Mar 2021 09:23:51 GMT

Protected "7m56" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:23, 31 March 2021

OCA: New page: '''Unreleased structure''' The entry 7m56 is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of human endothelial nitric oxide synthase heme domain in complex with 7-((3-(...

OCA — Wed, 31 Mar 2021 09:23:50 GMT

New page: '''Unreleased structure''' The entry 7m56 is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of human endothelial nitric oxide synthase heme domain in complex with 7-((3-(...

New page

'''Unreleased structure'''

The entry 7m56 is ON HOLD

Authors: Li, H., Poulos, T.L.

Description: Structure of human endothelial nitric oxide synthase heme domain in complex with 7-((3-(3-aminophenethyl)phenoxy)methyl)quinolin-2-amine
[[Category: Unreleased Structures]]
[[Category: Li, H]]
[[Category: Poulos, T.L]]