OCA at 16:09, 18 October 2023

OCA — Wed, 18 Oct 2023 16:09:23 GMT

←Older revision		Revision as of 16:09, 18 October 2023
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	==Crystal structure of Staphylococcus aureus Cystathionine gamma lyase, AOAA-bound enzyme in dimeric form==		==Crystal structure of Staphylococcus aureus Cystathionine gamma lyase, AOAA-bound enzyme in dimeric form==
-	<StructureSection load='7mcq' size='340' side='right'caption='[[7mcq]]' scene=''>	+	<StructureSection load='7mcq' size='340' side='right'caption='[[7mcq]], [[Resolution\|resolution]] 2.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MCQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7mcq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MCQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mcq OCA], [https://pdbe.org/7mcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mcq RCSB], [https://www.ebi.ac.uk/pdbsum/7mcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mcq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.84Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IK2:4-DEOXY-4-ACETYLYAMINO-PYRIDOXAL-5-PHOSPHATE'>IK2</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mcq OCA], [https://pdbe.org/7mcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mcq RCSB], [https://www.ebi.ac.uk/pdbsum/7mcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mcq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H3K724_STAAE A0A0H3K724_STAAE]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Emergent resistance to all clinical antibiotics calls for the next generation of therapeutics. Here we report an effective antimicrobial strategy targeting the bacterial hydrogen sulfide (H2S)-mediated defense system. We identified cystathionine gamma-lyase (CSE) as the primary generator of H2S in two major human pathogens, Staphylococcus aureus and Pseudomonas aeruginosa, and discovered small molecules that inhibit bacterial CSE. These inhibitors potentiate bactericidal antibiotics against both pathogens in vitro and in mouse models of infection. CSE inhibitors also suppress bacterial tolerance, disrupting biofilm formation and substantially reducing the number of persister bacteria that survive antibiotic treatment. Our results establish bacterial H2S as a multifunctional defense factor and CSE as a drug target for versatile antibiotic enhancers.
		+
		+	Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance.,Shatalin K, Nuthanakanti A, Kaushik A, Shishov D, Peselis A, Shamovsky I, Pani B, Lechpammer M, Vasilyev N, Shatalina E, Rebatchouk D, Mironov A, Fedichev P, Serganov A, Nudler E Science. 2021 Jun 11;372(6547):1169-1175. doi: 10.1126/science.abd8377. PMID:34112687<ref>PMID:34112687</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7mcq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cystathionine beta-lyase\|Cystathionine beta-lyase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Staphylococcus aureus]]
	[[Category: Kaushik A]]		[[Category: Kaushik A]]
	[[Category: Nuthanakanti A]]		[[Category: Nuthanakanti A]]
	[[Category: Serganov A]]		[[Category: Serganov A]]

OCA at 07:32, 25 June 2021

OCA — Fri, 25 Jun 2021 07:32:54 GMT

←Older revision		Revision as of 07:32, 25 June 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7mcq is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of Staphylococcus aureus Cystathionine gamma lyase, AOAA-bound enzyme in dimeric form==
-		+	<StructureSection load='7mcq' size='340' side='right'caption='[[7mcq]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MCQ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mcq OCA], [https://pdbe.org/7mcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mcq RCSB], [https://www.ebi.ac.uk/pdbsum/7mcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mcq ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kaushik A]]
		+	[[Category: Nuthanakanti A]]
		+	[[Category: Serganov A]]

OCA at 08:08, 12 May 2021

OCA — Wed, 12 May 2021 08:08:03 GMT

←Older revision		Revision as of 08:08, 12 May 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7mcq is ON HOLD	+	The entry 7mcq is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7mcq" [edit=sysop:move=sysop]

OCA — Wed, 14 Apr 2021 05:40:34 GMT

Protected "7mcq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:40, 14 April 2021

OCA: New page: '''Unreleased structure''' The entry 7mcq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Apr 2021 05:40:33 GMT

New page: '''Unreleased structure''' The entry 7mcq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7mcq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7mcq - Revision history

OCA at 16:09, 18 October 2023

OCA at 07:32, 25 June 2021

OCA at 08:08, 12 May 2021

OCA: Protected "7mcq" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7mcq is ON HOLD Authors: Description: Category: Unreleased Structures