7mdn - Revision history

OCA at 13:11, 30 August 2023

OCA — Wed, 30 Aug 2023 13:11:52 GMT

←Older revision		Revision as of 13:11, 30 August 2023
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	==Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a==		==Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a==
-	<StructureSection load='7mdn' size='340' side='right'caption='[[7mdn]]' scene=''>	+	<StructureSection load='7mdn' size='340' side='right'caption='[[7mdn]], [[Resolution\|resolution]] 2.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MDN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7mdn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MDN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mdn OCA], [https://pdbe.org/7mdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mdn RCSB], [https://www.ebi.ac.uk/pdbsum/7mdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mdn ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.42Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=Y6V:~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide'>Y6V</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mdn OCA], [https://pdbe.org/7mdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mdn RCSB], [https://www.ebi.ac.uk/pdbsum/7mdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mdn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/NSD2_HUMAN NSD2_HUMAN] Wolf-Hirschhorn syndrome. A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH. WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NSD2_HUMAN NSD2_HUMAN] Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.<ref>PMID:11152655</ref> <ref>PMID:16115125</ref> <ref>PMID:18172012</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith CH]]		[[Category: Arrowsmith CH]]

OCA at 08:54, 5 May 2021

OCA — Wed, 05 May 2021 08:54:40 GMT

←Older revision		Revision as of 08:54, 5 May 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7mdn ~~is ON HOLD~~	+	==Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a==
-		+	<StructureSection load='7mdn' size='340' side='right'caption='[[7mdn]]' scene=''>
-	~~Authors~~: ~~Lei, M~~.~~, Freitas, R~~.F.~~, Dong, A~~.~~, Schapira, M~~., ~~Arrowsmith, C~~.H., ~~Edwards~~, A.M., ~~Min, J~~., ~~Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MDN FirstGlance]. <br>
-	~~Description~~: ~~Histone-lysine N-methyltransferase NSD2~~-~~PWWP1 with compound MRT10241866a~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mdn OCA], [https://pdbe.org/7mdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mdn RCSB], [https://www.ebi.ac.uk/pdbsum/7mdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mdn ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Freitas, R.F~~]]	+	__TOC__
-	[[Category: ~~Schapira, M]]~~	+	</StructureSection>
-	~~[[Category: Min, J~~]]	+	[[Category: Large Structures]]
-	[[Category: Edwards~~, A.M~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: ~~Arrowsmith, C.H~~]]	+	[[Category: Dong A]]
-	[[Category: ~~Dong, A~~]]	+	[[Category: Edwards AM]]
-	[[Category: ~~Structural Genomics Consortium (Sgc)~~]]	+	[[Category: Freitas RF]]
-	[[Category: ~~Lei,~~ M]]	+	[[Category: Lei M]]
		+	[[Category: Min J]]
		+	[[Category: Schapira M]]

OCA: Protected "7mdn" [edit=sysop:move=sysop]

OCA — Wed, 14 Apr 2021 05:42:30 GMT

Protected "7mdn" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 14 April 2021

OCA: New page: '''Unreleased structure''' The entry 7mdn is ON HOLD Authors: Lei, M., Freitas, R.F., Dong, A., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (S...

OCA — Wed, 14 Apr 2021 05:42:29 GMT

New page: '''Unreleased structure''' The entry 7mdn is ON HOLD Authors: Lei, M., Freitas, R.F., Dong, A., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (S...

New page

'''Unreleased structure'''

The entry 7mdn is ON HOLD

Authors: Lei, M., Freitas, R.F., Dong, A., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)

Description: Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a
[[Category: Unreleased Structures]]
[[Category: Freitas, R.F]]
[[Category: Schapira, M]]
[[Category: Min, J]]
[[Category: Edwards, A.M]]
[[Category: Arrowsmith, C.H]]
[[Category: Dong, A]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Lei, M]]