7met - Revision history

OCA at 19:39, 29 May 2024

OCA — Wed, 29 May 2024 19:39:25 GMT

←Older revision		Revision as of 19:39, 29 May 2024
Line 3:		Line 3:
	<StructureSection load='7met' size='340' side='right'caption='[[7met]], [[Resolution\|resolution]] 3.97Å' scene=''>		<StructureSection load='7met' size='340' side='right'caption='[[7met]], [[Resolution\|resolution]] 3.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[7met]] is a 2 chain structure.~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MET FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MET FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=Z5G:2-(4-chlorobenzamido)-4~~,~~5,6,7-tetrahydro-1-benzothiophene-~~3~~-carboxylic+acid'>Z5G</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.97Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks'>[https~~:~~//en.wikipedia.org/wiki/ABC~~-~~type_lipid_A~~-~~core_oligosaccharide_transporter ABC~~-~~type lipid A-core oligosaccharide transporter]~~, ~~with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=7.~~5~~.2.~~6 7~~.5.2.6]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Z5G:2-(4-chlorobenzamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic+acid'>Z5G</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7met FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7met OCA], [https://pdbe.org/7met PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7met RCSB], [https://www.ebi.ac.uk/pdbsum/7met PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7met ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7met FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7met OCA], [https://pdbe.org/7met PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7met RCSB], [https://www.ebi.ac.uk/pdbsum/7met PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7met ProSAT]</span></td></tr>
	</table>		</table>
-	== Function ==
-	[[https://www.uniprot.org/uniprot/A0A0B9X4I2_ACIBA A0A0B9X4I2_ACIBA]] Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.[HAMAP-Rule:MF_01703]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ABC-type lipid A-core oligosaccharide transporter]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liao, M]]	+	[[Category: Liao M]]
-	[[Category: Thelot, F]]	+	[[Category: Thelot F]]
-	~~[[Category: Membrane protein~~]]	+

OCA at 07:58, 10 November 2021

OCA — Wed, 10 Nov 2021 07:58:59 GMT

←Older revision		Revision as of 07:58, 10 November 2021
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	==A. baumannii MsbA in complex with TBT1 decoupler==		==A. baumannii MsbA in complex with TBT1 decoupler==
-	<StructureSection load='7met' size='340' side='right'caption='[[7met]]' scene=''>	+	<StructureSection load='7met' size='340' side='right'caption='[[7met]], [[Resolution\|resolution]] 3.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MET FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7met]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MET FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7met FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7met OCA], [https://pdbe.org/7met PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7met RCSB], [https://www.ebi.ac.uk/pdbsum/7met PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7met ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Z5G:2-(4-chlorobenzamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic+acid'>Z5G</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ABC-type_lipid_A-core_oligosaccharide_transporter ABC-type lipid A-core oligosaccharide transporter], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=7.5.2.6 7.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7met FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7met OCA], [https://pdbe.org/7met PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7met RCSB], [https://www.ebi.ac.uk/pdbsum/7met PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7met ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/A0A0B9X4I2_ACIBA A0A0B9X4I2_ACIBA]] Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.[HAMAP-Rule:MF_01703]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ATP-binding cassette (ABC) transporters couple ATP hydrolysis to substrate transport across biological membranes. Although many are promising drug targets, their mechanisms of modulation by small molecule inhibitors remain largely unknown. Intriguingly, two first-generation inhibitors of the MsbA transporter, TBT1 and G247, induce opposite effects on ATP hydrolysis. Using single-particle cryo-electron microscopy and functional assays, we show that TBT1 and G247 bind adjacent yet separate pockets in the MsbA transmembrane domains. Two TBT1 molecules asymmetrically occupy the substrate binding site, leading to a collapsed inward-facing conformation with decreased distance between the nucleotide-binding domains (NBDs). In contrast, two G247 molecules symmetrically increases NBD distance in a wide inward-open state of MsbA. The divergent mechanisms of action of these MsbA inhibitors provide important insights into ABC transporter pharmacology.
		+
		+	Distinct allosteric mechanisms of first-generation MsbA inhibitors.,Thelot FA, Zhang W, Song K, Xu C, Huang J, Liao M Science. 2021 Sep 23. doi: 10.1126/science.abi9009. PMID:34554829<ref>PMID:34554829</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7met" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: ABC-type lipid A-core oligosaccharide transporter]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liao M]]	+	[[Category: Liao, M]]
-	[[Category: Thelot F]]	+	[[Category: Thelot, F]]
		+	[[Category: Membrane protein]]

OCA at 05:31, 6 October 2021

OCA — Wed, 06 Oct 2021 05:31:22 GMT

←Older revision		Revision as of 05:31, 6 October 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7met ~~is ON HOLD~~	+	==A. baumannii MsbA in complex with TBT1 decoupler==
-		+	<StructureSection load='7met' size='340' side='right'caption='[[7met]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MET FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7met FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7met OCA], [https://pdbe.org/7met PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7met RCSB], [https://www.ebi.ac.uk/pdbsum/7met PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7met ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Liao M]]
		+	[[Category: Thelot F]]

OCA at 05:27, 22 September 2021

OCA — Wed, 22 Sep 2021 05:27:03 GMT

←Older revision		Revision as of 05:27, 22 September 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7met is ON HOLD ~~until Paper Publication~~	+	The entry 7met is ON HOLD

	Authors:		Authors:

OCA at 08:09, 12 May 2021

OCA — Wed, 12 May 2021 08:09:11 GMT

←Older revision		Revision as of 08:09, 12 May 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7met is ON HOLD	+	The entry 7met is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7met" [edit=sysop:move=sysop]

OCA — Wed, 14 Apr 2021 05:44:35 GMT

Protected "7met" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:44, 14 April 2021

OCA: New page: '''Unreleased structure''' The entry 7met is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Apr 2021 05:44:34 GMT

New page: '''Unreleased structure''' The entry 7met is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7met is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]