OCA at 10:54, 28 July 2021

OCA — Wed, 28 Jul 2021 10:54:35 GMT

←Older revision		Revision as of 10:54, 28 July 2021
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	==Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius==		==Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius==
-	<StructureSection load='7mij' size='340' side='right'caption='[[7mij]]' scene=''>	+	<StructureSection load='7mij' size='340' side='right'caption='[[7mij]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MIJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7mij]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MIJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mij OCA], [https://pdbe.org/7mij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mij RCSB], [https://www.ebi.ac.uk/pdbsum/7mij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mij ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Trpv3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mij OCA], [https://pdbe.org/7mij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mij RCSB], [https://www.ebi.ac.uk/pdbsum/7mij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mij ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Numerous physiological functions rely on distinguishing temperature through temperature-sensitive transient receptor potential channels (thermo-TRPs). Although the function of thermo-TRPs has been studied extensively, structural determination of their heat- and cold-activated states has remained a challenge. Here, we present cryo-EM structures of the nanodisc-reconstituted wild-type mouse TRPV3 in three distinct conformations: closed, heat-activated sensitized and open states. The heat-induced transformations of TRPV3 are accompanied by changes in the secondary structure of the S2-S3 linker and the N and C termini and represent a conformational wave that links these parts of the protein to a lipid occupying the vanilloid binding site. State-dependent differences in the behavior of bound lipids suggest their active role in thermo-TRP temperature-dependent gating. Our structural data, supported by physiological recordings and molecular dynamics simulations, provide an insight for understanding the molecular mechanism of temperature sensing.
		+
		+	Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.,Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI Nat Struct Mol Biol. 2021 Jul;28(7):564-572. doi: 10.1038/s41594-021-00615-4., Epub 2021 Jul 8. PMID:34239124<ref>PMID:34239124</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7mij" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Nadezhdin KD]]	+	[[Category: Lk3 transgenic mice]]
-	[[Category: Neuberger A]]	+	[[Category: Nadezhdin, K D]]
-	[[Category: Sobolevsky AI]]	+	[[Category: Neuberger, A]]
		+	[[Category: Sobolevsky, A I]]
		+	[[Category: Closed state at 4 degrees celsius]]
		+	[[Category: Membrane protein]]
		+	[[Category: Msp2n2]]
		+	[[Category: Transient receptor potential v family member 3]]
		+	[[Category: Trp channel]]
		+	[[Category: Trpv3]]

OCA at 08:58, 21 July 2021

OCA — Wed, 21 Jul 2021 08:58:38 GMT

←Older revision		Revision as of 08:58, 21 July 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7mij is ~~ON HOLD until Paper Publication~~	+	==Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius==
-		+	<StructureSection load='7mij' size='340' side='right'caption='[[7mij]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MIJ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mij OCA], [https://pdbe.org/7mij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mij RCSB], [https://www.ebi.ac.uk/pdbsum/7mij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mij ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Nadezhdin KD]]
		+	[[Category: Neuberger A]]
		+	[[Category: Sobolevsky AI]]

OCA at 07:54, 26 May 2021

OCA — Wed, 26 May 2021 07:54:18 GMT

←Older revision		Revision as of 07:54, 26 May 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7mij is ON HOLD	+	The entry 7mij is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7mij" [edit=sysop:move=sysop]

OCA — Wed, 28 Apr 2021 04:19:12 GMT

Protected "7mij" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:19, 28 April 2021

OCA: New page: '''Unreleased structure''' The entry 7mij is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Apr 2021 04:19:12 GMT

New page: '''Unreleased structure''' The entry 7mij is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7mij is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7mij - Revision history

OCA at 10:54, 28 July 2021

OCA at 08:58, 21 July 2021

OCA at 07:54, 26 May 2021

OCA: Protected "7mij" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7mij is ON HOLD Authors: Description: Category: Unreleased Structures