OCA at 10:39, 22 May 2024

OCA — Wed, 22 May 2024 10:39:09 GMT

←Older revision		Revision as of 10:39, 22 May 2024
Line 1:		Line 1:

-	====	+	==Crystal structure of Drosophila Panoramix in complex with Sov NTD==
-	<StructureSection load='7mkk' size='340' side='right'caption='[[7mkk]]' scene=''>	+	<StructureSection load='7mkk' size='340' side='right'caption='[[7mkk]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7mkk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MKK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mkk OCA], [https://pdbe.org/7mkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mkk RCSB], [https://www.ebi.ac.uk/pdbsum/7mkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mkk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mkk OCA], [https://pdbe.org/7mkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mkk RCSB], [https://www.ebi.ac.uk/pdbsum/7mkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mkk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9W3W6_DROME Q9W3W6_DROME]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nuclear Argonaute proteins, guided by small RNAs, mediate sequence-specific heterochromatin formation. The molecular principles that link Argonaute-small RNA complexes to cellular heterochromatin effectors on binding to nascent target RNAs are poorly understood. Here, we explain the mechanism by which the PIWI-interacting RNA (piRNA) pathway connects to the heterochromatin machinery in Drosophila. We find that Panoramix, a corepressor required for piRNA-guided heterochromatin formation, is SUMOylated on chromatin in a Piwi-dependent manner. SUMOylation, together with an amphipathic LxxLL motif in Panoramix's intrinsically disordered repressor domain, are necessary and sufficient to recruit Small ovary (Sov), a multi-zinc-finger protein essential for general heterochromatin formation and viability. Structure-guided mutations that eliminate the Panoramix-Sov interaction or that prevent SUMOylation of Panoramix uncouple Sov from the piRNA pathway, resulting in viable but sterile flies in which Piwi-targeted transposons are derepressed. Thus, Piwi engages the heterochromatin machinery specifically at transposon loci by coupling recruitment of a corepressor to nascent transcripts with its SUMOylation.
		+
		+	Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.,Andreev VI, Yu C, Wang J, Schnabl J, Tirian L, Gehre M, Handler D, Duchek P, Novatchkova M, Baumgartner L, Meixner K, Sienski G, Patel DJ, Brennecke J Nat Struct Mol Biol. 2022 Feb;29(2):130-142. doi: 10.1038/s41594-022-00721-x. , Epub 2022 Feb 16. PMID:35173350<ref>PMID:35173350</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7mkk" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Patel DJ]]
		+	[[Category: Wang J]]

OCA at 06:59, 2 February 2022

OCA — Wed, 02 Feb 2022 06:59:35 GMT

←Older revision		Revision as of 06:59, 2 February 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7mkk ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7mkk' size='340' side='right'caption='[[7mkk]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mkk OCA], [https://pdbe.org/7mkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mkk RCSB], [https://www.ebi.ac.uk/pdbsum/7mkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mkk ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7mkk" [edit=sysop:move=sysop]

OCA — Wed, 05 May 2021 07:26:09 GMT

Protected "7mkk" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:26, 5 May 2021

OCA: New page: '''Unreleased structure''' The entry 7mkk is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 May 2021 07:26:07 GMT

New page: '''Unreleased structure''' The entry 7mkk is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7mkk is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7mkk - Revision history

OCA at 10:39, 22 May 2024

OCA at 06:59, 2 February 2022

OCA: Protected "7mkk" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7mkk is ON HOLD Authors: Description: Category: Unreleased Structures