7mpt - Revision history

OCA at 16:18, 18 October 2023

OCA — Wed, 18 Oct 2023 16:18:13 GMT

←Older revision		Revision as of 16:18, 18 October 2023
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	<StructureSection load='7mpt' size='340' side='right'caption='[[7mpt]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='7mpt' size='340' side='right'caption='[[7mpt]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7mpt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MPT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7mpt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_melitensis Brucella melitensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MPT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https:~~/~~/en.wikipedia.org/wiki/Ribonuclease_D Ribonuclease D]~~, ~~with EC number [https~~:~~//www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.5 3.1.13.5]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mpt OCA], [https://pdbe.org/7mpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mpt RCSB], [https://www.ebi.ac.uk/pdbsum/7mpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mpt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mpt OCA], [https://pdbe.org/7mpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mpt RCSB], [https://www.ebi.ac.uk/pdbsum/7mpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mpt ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2X1C2S7_BRUML A0A2X1C2S7_BRUML]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7mpt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7mpt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brucella melitensis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Ribonuclease D]]~~	+	[[Category: Lormand JD]]
-	[[Category: Lormand~~, J D~~]]	+	[[Category: Sondermann H]]
-	[[Category: Sondermann, H]]	+
-	~~[[Category: Bacteria]]~~	+
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rnase~~]]	+

OCA at 09:02, 29 September 2021

OCA — Wed, 29 Sep 2021 09:02:50 GMT

←Older revision		Revision as of 09:02, 29 September 2021
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	==Brucella melitensis NrnC with bound Mg2+==		==Brucella melitensis NrnC with bound Mg2+==
-	<StructureSection load='7mpt' size='340' side='right'caption='[[7mpt]]' scene=''>	+	<StructureSection load='7mpt' size='340' side='right'caption='[[7mpt]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MPT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7mpt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MPT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mpt OCA], [https://pdbe.org/7mpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mpt RCSB], [https://www.ebi.ac.uk/pdbsum/7mpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mpt ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribonuclease_D Ribonuclease D], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.5 3.1.13.5] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mpt OCA], [https://pdbe.org/7mpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mpt RCSB], [https://www.ebi.ac.uk/pdbsum/7mpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mpt ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RNA degradation is fundamental for cellular homeostasis. The process is carried out by various classes of endolytic and exolytic enzymes that together degrade an RNA polymer to mono-ribonucleotides. Within the exoribonucleases, nano-RNases play a unique role as they act on the smallest breakdown products and hence catalyze the final steps in the process. We recently showed that oligoribonuclease (Orn) acts as a dedicated diribonucleotidase, defining the ultimate step in RNA degradation that is crucial for cellular fitness (Kim et al., 2019). Whether such a specific activity exists in organisms that lack Orn-type exoribonucleases remained unclear. Through quantitative structure-function analyses we show here that NrnC-type RNases share this narrow substrate length preference with Orn. Although NrnC employs similar structural features that distinguish these two classes as dinucleotidases from other exonucleases, the key determinants for dinucleotidase activity are realized through distinct structural scaffolds. The structures together with comparative genomic analyses of the phylogeny of DEDD-type exoribonucleases indicates convergent evolution as the mechanism of how dinucleotidase activity emerged repeatedly in various organisms. The evolutionary pressure to maintain dinucleotidase activity further underlines the important role these analogous proteins play for cell growth.
		+
		+	Structural characterization of NrnC identifies unifying features of dinucleotidases.,Lormand JD, Kim SK, Walters-Marrah GA, Brownfield BA, Fromme JC, Winkler WC, Goodson JR, Lee VT, Sondermann H Elife. 2021 Sep 17;10. pii: 70146. doi: 10.7554/eLife.70146. PMID:34533457<ref>PMID:34533457</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7mpt" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lormand JD]]	+	[[Category: Ribonuclease D]]
-	[[Category: Sondermann H]]	+	[[Category: Lormand, J D]]
		+	[[Category: Sondermann, H]]
		+	[[Category: Bacteria]]
		+	[[Category: Enzyme]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rnase]]

OCA at 09:27, 15 September 2021

OCA — Wed, 15 Sep 2021 09:27:14 GMT

←Older revision		Revision as of 09:27, 15 September 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7mpt ~~is ON HOLD~~	+	==Brucella melitensis NrnC with bound Mg2+==
-		+	<StructureSection load='7mpt' size='340' side='right'caption='[[7mpt]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MPT FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mpt OCA], [https://pdbe.org/7mpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mpt RCSB], [https://www.ebi.ac.uk/pdbsum/7mpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mpt ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lormand JD]]
		+	[[Category: Sondermann H]]

OCA at 07:24, 8 September 2021

OCA — Wed, 08 Sep 2021 07:24:19 GMT

←Older revision		Revision as of 07:24, 8 September 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7mpt is ON HOLD ~~until Paper Publication~~	+	The entry 7mpt is ON HOLD

	Authors:		Authors:

OCA at 13:36, 17 June 2021

OCA — Thu, 17 Jun 2021 13:36:26 GMT

←Older revision		Revision as of 13:36, 17 June 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7mpt is ON HOLD	+	The entry 7mpt is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7mpt" [edit=sysop:move=sysop]

OCA — Wed, 12 May 2021 08:15:30 GMT

Protected "7mpt" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:15, 12 May 2021

OCA: New page: '''Unreleased structure''' The entry 7mpt is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 May 2021 08:15:29 GMT

New page: '''Unreleased structure''' The entry 7mpt is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7mpt is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]