OCA at 19:40, 29 May 2024

OCA — Wed, 29 May 2024 19:40:31 GMT

←Older revision		Revision as of 19:40, 29 May 2024
Line 1:		Line 1:

-	====	+	==Bartonella henselae NrnC complexed with pAGG. D4 symmetry.==
-	<StructureSection load='7mqd' size='340' side='right'caption='[[7mqd]]' scene=''>	+	<StructureSection load='7mqd' size='340' side='right'caption='[[7mqd]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7mqd]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Bartonella_henselae Bartonella henselae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MQD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mqd OCA], [https://pdbe.org/7mqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mqd RCSB], [https://www.ebi.ac.uk/pdbsum/7mqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mqd ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.25Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mqd OCA], [https://pdbe.org/7mqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mqd RCSB], [https://www.ebi.ac.uk/pdbsum/7mqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mqd ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/X5MEI1_BARHN X5MEI1_BARHN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RNA degradation is fundamental for cellular homeostasis. The process is carried out by various classes of endolytic and exolytic enzymes that together degrade an RNA polymer to mono-ribonucleotides. Within the exoribonucleases, nano-RNases play a unique role as they act on the smallest breakdown products and hence catalyze the final steps in the process. We recently showed that oligoribonuclease (Orn) acts as a dedicated diribonucleotidase, defining the ultimate step in RNA degradation that is crucial for cellular fitness (Kim et al., 2019). Whether such a specific activity exists in organisms that lack Orn-type exoribonucleases remained unclear. Through quantitative structure-function analyses we show here that NrnC-type RNases share this narrow substrate length preference with Orn. Although NrnC employs similar structural features that distinguish these two classes as dinucleotidases from other exonucleases, the key determinants for dinucleotidase activity are realized through distinct structural scaffolds. The structures together with comparative genomic analyses of the phylogeny of DEDD-type exoribonucleases indicates convergent evolution as the mechanism of how dinucleotidase activity emerged repeatedly in various organisms. The evolutionary pressure to maintain dinucleotidase activity further underlines the important role these analogous proteins play for cell growth.
		+
		+	Structural characterization of NrnC identifies unifying features of dinucleotidases.,Lormand JD, Kim SK, Walters-Marrah GA, Brownfield BA, Fromme JC, Winkler WC, Goodson JR, Lee VT, Sondermann H Elife. 2021 Sep 17;10. pii: 70146. doi: 10.7554/eLife.70146. PMID:34533457<ref>PMID:34533457</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7mqd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bartonella henselae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: Brownfield B]]
		+	[[Category: Fromme JC]]
		+	[[Category: Lormand JD]]
		+	[[Category: Sondermann H]]

OCA at 09:27, 15 September 2021

OCA — Wed, 15 Sep 2021 09:27:18 GMT

←Older revision		Revision as of 09:27, 15 September 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7mqd ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7mqd' size='340' side='right'caption='[[7mqd]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mqd OCA], [https://pdbe.org/7mqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mqd RCSB], [https://www.ebi.ac.uk/pdbsum/7mqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mqd ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 13:36, 17 June 2021

OCA — Thu, 17 Jun 2021 13:36:36 GMT

←Older revision		Revision as of 13:36, 17 June 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7mqd is ON HOLD	+	The entry 7mqd is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7mqd" [edit=sysop:move=sysop]

OCA — Wed, 12 May 2021 08:16:28 GMT

Protected "7mqd" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:16, 12 May 2021

OCA: New page: '''Unreleased structure''' The entry 7mqd is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 May 2021 08:16:27 GMT

New page: '''Unreleased structure''' The entry 7mqd is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7mqd is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7mqd - Revision history

OCA at 19:40, 29 May 2024

OCA at 09:27, 15 September 2021

OCA at 13:36, 17 June 2021

OCA: Protected "7mqd" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7mqd is ON HOLD Authors: Description: Category: Unreleased Structures