OCA at 17:37, 1 November 2023

OCA — Wed, 01 Nov 2023 17:37:29 GMT

←Older revision		Revision as of 17:37, 1 November 2023
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-	====	+	==Structure of the SARS-CoV-2 Spike trimer with all RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6==
-	<StructureSection load='7mw2' size='340' side='right'caption='[[7mw2]]' scene=''>	+	<StructureSection load='7mw2' size='340' side='right'caption='[[7mw2]], [[Resolution\|resolution]] 2.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7mw2]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MW2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mw2 OCA], [https://pdbe.org/7mw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mw2 RCSB], [https://www.ebi.ac.uk/pdbsum/7mw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mw2 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.97Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mw2 OCA], [https://pdbe.org/7mw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mw2 RCSB], [https://www.ebi.ac.uk/pdbsum/7mw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mw2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Hu Y]]
		+	[[Category: Xiong Y]]

OCA at 06:14, 16 March 2022

OCA — Wed, 16 Mar 2022 06:14:04 GMT

←Older revision		Revision as of 06:14, 16 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7mw2 ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7mw2' size='340' side='right'caption='[[7mw2]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mw2 OCA], [https://pdbe.org/7mw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mw2 RCSB], [https://www.ebi.ac.uk/pdbsum/7mw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mw2 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7mw2" [edit=sysop:move=sysop]

OCA — Wed, 26 May 2021 07:59:40 GMT

Protected "7mw2" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:59, 26 May 2021

OCA: New page: '''Unreleased structure''' The entry 7mw2 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 May 2021 07:59:39 GMT

New page: '''Unreleased structure''' The entry 7mw2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7mw2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7mw2 - Revision history

OCA at 17:37, 1 November 2023

OCA at 06:14, 16 March 2022

OCA: Protected "7mw2" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7mw2 is ON HOLD Authors: Description: Category: Unreleased Structures