7n03 - Revision history

OCA at 16:22, 18 October 2023

OCA — Wed, 18 Oct 2023 16:22:22 GMT

←Older revision		Revision as of 16:22, 18 October 2023
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	<StructureSection load='7n03' size='340' side='right'caption='[[7n03]], [[Resolution\|resolution]] 1.13Å' scene=''>		<StructureSection load='7n03' size='340' side='right'caption='[[7n03]], [[Resolution\|resolution]] 1.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7n03]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N03 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7n03]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N03 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZRP:4-anilino-6-(hexylamino)-N-methylquinoline-3-carboxamide'>ZRP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.13Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZRP:4-anilino-6-(hexylamino)-N-methylquinoline-3-carboxamide'>ZRP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n03 OCA], [https://pdbe.org/7n03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n03 RCSB], [https://www.ebi.ac.uk/pdbsum/7n03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n03 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n03 OCA], [https://pdbe.org/7n03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n03 RCSB], [https://www.ebi.ac.uk/pdbsum/7n03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n03 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>	+	[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eron~~, S J]]~~	+	[[Category: Eron SJ]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inhibitor~~]]	+

OCA at 10:04, 12 January 2022

OCA — Wed, 12 Jan 2022 10:04:05 GMT

←Older revision		Revision as of 10:04, 12 January 2022
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	==Crystal structure of MTH1 in complex with compound 31==		==Crystal structure of MTH1 in complex with compound 31==
-	<StructureSection load='7n03' size='340' side='right'caption='[[7n03]]' scene=''>	+	<StructureSection load='7n03' size='340' side='right'caption='[[7n03]], [[Resolution\|resolution]] 1.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N03 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7n03]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N03 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n03 OCA], [https://pdbe.org/7n03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n03 RCSB], [https://www.ebi.ac.uk/pdbsum/7n03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n03 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZRP:4-anilino-6-(hexylamino)-N-methylquinoline-3-carboxamide'>ZRP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n03 OCA], [https://pdbe.org/7n03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n03 RCSB], [https://www.ebi.ac.uk/pdbsum/7n03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n03 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eron SJ]]	+	[[Category: Eron, S J]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Inhibitor]]

OCA at 14:30, 3 November 2021

OCA — Wed, 03 Nov 2021 14:30:53 GMT

←Older revision		Revision as of 14:30, 3 November 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7n03 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of MTH1 in complex with compound 31==
-		+	<StructureSection load='7n03' size='340' side='right'caption='[[7n03]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N03 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n03 OCA], [https://pdbe.org/7n03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n03 RCSB], [https://www.ebi.ac.uk/pdbsum/7n03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n03 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Eron SJ]]

OCA: Protected "7n03" [edit=sysop:move=sysop]

OCA — Wed, 02 Jun 2021 13:31:56 GMT

Protected "7n03" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:31, 2 June 2021

OCA: New page: '''Unreleased structure''' The entry 7n03 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Jun 2021 13:31:55 GMT

New page: '''Unreleased structure''' The entry 7n03 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7n03 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]