7n8j - Revision history

OCA at 16:25, 18 October 2023

OCA — Wed, 18 Oct 2023 16:25:40 GMT

←Older revision		Revision as of 16:25, 18 October 2023
Line 1:		Line 1:

-	====	+	==Human importin alpha 1 in complex with Bimax2 peptide==
-	<StructureSection load='7n8j' size='340' side='right'caption='[[7n8j]]' scene=''>	+	<StructureSection load='7n8j' size='340' side='right'caption='[[7n8j]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7n8j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N8J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n8j OCA], [https://pdbe.org/7n8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n8j RCSB], [https://www.ebi.ac.uk/pdbsum/7n8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n8j ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n8j OCA], [https://pdbe.org/7n8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n8j RCSB], [https://www.ebi.ac.uk/pdbsum/7n8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n8j ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IMA1_HUMAN IMA1_HUMAN] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
		+
		+	==See Also==
		+	*[[Importin 3D structures\|Importin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: Cross EM]]
		+	[[Category: Donnelly CM]]
		+	[[Category: Forwood JK]]
		+	[[Category: Tsimbalyuk S]]

OCA at 03:34, 2 July 2021

OCA — Fri, 02 Jul 2021 03:34:52 GMT

←Older revision		Revision as of 03:34, 2 July 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7n8j ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7n8j' size='340' side='right'caption='[[7n8j]]' scene=''>
-	~~Authors~~: ~~Donnelly, C~~.M.~~, Cross, E~~.M.~~, Tsimbalyuk, S~~.~~, Forwood, J~~.K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Human importin alpha 1 in complex with Bimax2 peptide~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n8j OCA], [https://pdbe.org/7n8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n8j RCSB], [https://www.ebi.ac.uk/pdbsum/7n8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n8j ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Forwood~~, J.K]]	+	__TOC__
-	[~~[Category~~: ~~Tsimbalyuk, S~~]]	+	</StructureSection>
-	[[Category: ~~Cross, E.M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Donnelly, C.M~~]]	+	[[Category: Z-disk]]

OCA: Protected "7n8j" [edit=sysop:move=sysop]

OCA — Fri, 25 Jun 2021 06:15:40 GMT

Protected "7n8j" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:15, 25 June 2021

OCA: New page: '''Unreleased structure''' The entry 7n8j is ON HOLD Authors: Donnelly, C.M., Cross, E.M., Tsimbalyuk, S., Forwood, J.K. Description: Human importin alpha 1 in complex with Bimax2 pept...

OCA — Fri, 25 Jun 2021 06:15:39 GMT

New page: '''Unreleased structure''' The entry 7n8j is ON HOLD Authors: Donnelly, C.M., Cross, E.M., Tsimbalyuk, S., Forwood, J.K. Description: Human importin alpha 1 in complex with Bimax2 pept...

New page

'''Unreleased structure'''

The entry 7n8j is ON HOLD

Authors: Donnelly, C.M., Cross, E.M., Tsimbalyuk, S., Forwood, J.K.

Description: Human importin alpha 1 in complex with Bimax2 peptide
[[Category: Unreleased Structures]]
[[Category: Forwood, J.K]]
[[Category: Tsimbalyuk, S]]
[[Category: Cross, E.M]]
[[Category: Donnelly, C.M]]