7npo - Revision history

OCA at 12:38, 1 February 2024

OCA — Thu, 01 Feb 2024 12:38:07 GMT

←Older revision		Revision as of 12:38, 1 February 2024
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-	====	+	==Branched K48-K63-Ub3==
-	<StructureSection load='7npo' size='340' side='right'caption='[[7npo]]' scene=''>	+	<StructureSection load='7npo' size='340' side='right'caption='[[7npo]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7npo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NPO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7npo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7npo OCA], [https://pdbe.org/7npo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7npo RCSB], [https://www.ebi.ac.uk/pdbsum/7npo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7npo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.19Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7npo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7npo OCA], [https://pdbe.org/7npo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7npo RCSB], [https://www.ebi.ac.uk/pdbsum/7npo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7npo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/UBB_HUMAN UBB_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Kulathu Y]]
		+	[[Category: Kwasna D]]
		+	[[Category: Lange SM]]

OCA at 04:58, 10 August 2022

OCA — Wed, 10 Aug 2022 04:58:28 GMT

←Older revision		Revision as of 04:58, 10 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7npo ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7npo' size='340' side='right'caption='[[7npo]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7npo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7npo OCA], [https://pdbe.org/7npo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7npo RCSB], [https://www.ebi.ac.uk/pdbsum/7npo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7npo ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 09:29, 31 March 2021

OCA — Wed, 31 Mar 2021 09:29:29 GMT

←Older revision		Revision as of 09:29, 31 March 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7npo is ON HOLD	+	The entry 7npo is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7npo" [edit=sysop:move=sysop]

OCA — Wed, 10 Mar 2021 15:01:59 GMT

Protected "7npo" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:01, 10 March 2021

OCA: New page: '''Unreleased structure''' The entry 7npo is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 Mar 2021 15:01:57 GMT

New page: '''Unreleased structure''' The entry 7npo is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7npo is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]