7nqb - Revision history

OCA at 12:38, 1 February 2024

OCA — Thu, 01 Feb 2024 12:38:19 GMT

←Older revision		Revision as of 12:38, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7nqb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NQB FirstGlance]. <br>		<table><tr><td colspan='2'>[[7nqb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NQB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.01Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nqb OCA], [https://pdbe.org/7nqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nqb RCSB], [https://www.ebi.ac.uk/pdbsum/7nqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nqb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nqb OCA], [https://pdbe.org/7nqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nqb RCSB], [https://www.ebi.ac.uk/pdbsum/7nqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nqb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN]] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.	+	[https://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7nqb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7nqb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactoglobulin 3D structures\|Beta-lactoglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ferraro, G]]	+	[[Category: Ferraro G]]
-	[[Category: Loreto, D]]	+	[[Category: Loreto D]]
-	[[Category: Merlino, A]]	+	[[Category: Merlino A]]
-	~~[[Category: Beta-lactoglobulin]]~~	+
-	~~[[Category: Drug delivery]]~~	+
-	~~[[Category: Metal-based drug]]~~	+
-	~~[[Category: Oxaliplatin]]~~	+
-	~~[[Category: Protein-metalation]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 13:05, 4 May 2022

OCA — Wed, 04 May 2022 13:05:05 GMT

←Older revision		Revision as of 13:05, 4 May 2022
Line 1:		Line 1:

	==X.ray structure of the oxaliplatin/beta-lactoglobulin adduct==		==X.ray structure of the oxaliplatin/beta-lactoglobulin adduct==
-	<StructureSection load='7nqb' size='340' side='right'caption='[[7nqb]]' scene=''>	+	<StructureSection load='7nqb' size='340' side='right'caption='[[7nqb]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NQB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7nqb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NQB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nqb OCA], [https://pdbe.org/7nqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nqb RCSB], [https://www.ebi.ac.uk/pdbsum/7nqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nqb ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nqb OCA], [https://pdbe.org/7nqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nqb RCSB], [https://www.ebi.ac.uk/pdbsum/7nqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nqb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN]] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	beta-lactoglobulin is the major component of whey. Here, the adduct formed upon the reaction of the protein with oxaliplatin (OXA) has been prepared, structurally characterized by X-ray crystallography and electrospray ionization-mass spectrometry, and evaluated as a cytotoxic agent. The data demonstrate that OXA rapidly binds beta-lactoglobulin via coordination with a Met7 side chain upon release of the oxalate ligand. The adduct is significantly more cytotoxic than the free drug and induces apoptosis in cancer cells. Overall, our results suggest that metallodrug/beta-lactoglobulin adducts can be used as anticancer agents and that the protein can be used as a metallodrug delivery system.
		+
		+	Protein-Based Delivery Systems for Anticancer Metallodrugs: Structure and Biological Activity of the Oxaliplatin/beta-Lactoglobulin Adduct.,Monti DM, Loreto D, Iacobucci I, Ferraro G, Pratesi A, D'Elia L, Monti M, Merlino A Pharmaceuticals (Basel). 2022 Mar 30;15(4). pii: ph15040425. doi:, 10.3390/ph15040425. PMID:35455422<ref>PMID:35455422</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7nqb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ferraro G]]	+	[[Category: Ferraro, G]]
-	[[Category: Loreto D]]	+	[[Category: Loreto, D]]
-	[[Category: Merlino A]]	+	[[Category: Merlino, A]]
		+	[[Category: Beta-lactoglobulin]]
		+	[[Category: Drug delivery]]
		+	[[Category: Metal-based drug]]
		+	[[Category: Oxaliplatin]]
		+	[[Category: Protein-metalation]]
		+	[[Category: Transport protein]]

OCA at 11:17, 23 March 2022

OCA — Wed, 23 Mar 2022 11:17:48 GMT

←Older revision		Revision as of 11:17, 23 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7nqb is ~~ON HOLD until Paper Publication~~	+	==X.ray structure of the oxaliplatin/beta-lactoglobulin adduct==
-		+	<StructureSection load='7nqb' size='340' side='right'caption='[[7nqb]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NQB FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nqb OCA], [https://pdbe.org/7nqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nqb RCSB], [https://www.ebi.ac.uk/pdbsum/7nqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nqb ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ferraro G]]
		+	[[Category: Loreto D]]
		+	[[Category: Merlino A]]

OCA at 09:29, 31 March 2021

OCA — Wed, 31 Mar 2021 09:29:53 GMT

←Older revision		Revision as of 09:29, 31 March 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7nqb is ON HOLD	+	The entry 7nqb is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7nqb" [edit=sysop:move=sysop]

OCA — Wed, 10 Mar 2021 15:03:41 GMT

Protected "7nqb" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:03, 10 March 2021

OCA: New page: '''Unreleased structure''' The entry 7nqb is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 Mar 2021 15:03:40 GMT

New page: '''Unreleased structure''' The entry 7nqb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7nqb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]