7nrn - Revision history

OCA at 11:17, 14 June 2023

OCA — Wed, 14 Jun 2023 11:17:42 GMT

←Older revision		Revision as of 11:17, 14 June 2023
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	<StructureSection load='7nrn' size='340' side='right'caption='[[7nrn]]' scene=''>		<StructureSection load='7nrn' size='340' side='right'caption='[[7nrn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NRN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7nrn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NRN FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nrn OCA], [https://pdbe.org/7nrn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nrn RCSB], [https://www.ebi.ac.uk/pdbsum/7nrn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nrn ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nrn OCA], [https://pdbe.org/7nrn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nrn RCSB], [https://www.ebi.ac.uk/pdbsum/7nrn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nrn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GIPC1_MOUSE GIPC1_MOUSE] Inhibits endothelial cell migration (in vitro). May be involved in G protein-linked signaling (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	When combined with NMR spectroscopy, high hydrostatic pressure is an alternative perturbation method used to destabilize globular proteins that has proven to be particularly well suited for exploring the unfolding energy landscape of small single-domain proteins. To date, investigations of the unfolding landscape of all-beta or mixed-alpha/beta protein scaffolds are well documented, whereas such data are lacking for all-alpha protein domains. Here we report the NMR study of the unfolding pathways of GIPC1-GH2, a small alpha-helical bundle domain made of four antiparallel alpha-helices. High-pressure perturbation was combined with NMR spectroscopy to unravel the unfolding landscape at three different temperatures. The results were compared to those obtained from classical chemical denaturation. Whatever the perturbation used, the loss of secondary and tertiary contacts within the protein scaffold is almost simultaneous. The unfolding transition appeared very cooperative when using high pressure at high temperature, as was the case for chemical denaturation, whereas it was found more progressive at low temperature, suggesting the existence of a complex folding pathway.
		+
		+	Pressure and Chemical Unfolding of an alpha-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1.,Dubois C, Planelles-Herrero VJ, Tillatte-Tripodi C, Delbecq S, Mammri L, Sirkia EM, Ropars V, Roumestand C, Barthe P Int J Mol Sci. 2021 Mar 30;22(7). pii: ijms22073597. doi: 10.3390/ijms22073597. PMID:33808390<ref>PMID:33808390</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7nrn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
	[[Category: Barthe P]]		[[Category: Barthe P]]
	[[Category: Roumestand C]]		[[Category: Roumestand C]]

OCA at 06:48, 14 April 2021

OCA — Wed, 14 Apr 2021 06:48:48 GMT

←Older revision		Revision as of 06:48, 14 April 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7nrn ~~is ON HOLD until Paper Publication~~	+	==NMR structure of GIPC1-GH2 domain==
-		+	<StructureSection load='7nrn' size='340' side='right'caption='[[7nrn]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NRN FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nrn OCA], [https://pdbe.org/7nrn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nrn RCSB], [https://www.ebi.ac.uk/pdbsum/7nrn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nrn ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Barthe P]]
		+	[[Category: Roumestand C]]

OCA at 04:44, 7 April 2021

OCA — Wed, 07 Apr 2021 04:44:46 GMT

←Older revision		Revision as of 04:44, 7 April 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7nrn is ON HOLD	+	The entry 7nrn is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7nrn" [edit=sysop:move=sysop]

OCA — Wed, 10 Mar 2021 15:07:00 GMT

Protected "7nrn" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:07, 10 March 2021

OCA: New page: '''Unreleased structure''' The entry 7nrn is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 Mar 2021 15:06:58 GMT

New page: '''Unreleased structure''' The entry 7nrn is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7nrn is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]