7nup - Revision history

OCA at 12:40, 1 February 2024

OCA — Thu, 01 Feb 2024 12:40:09 GMT

←Older revision		Revision as of 12:40, 1 February 2024
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	==Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand==		==Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand==
-	<StructureSection load='7nup' size='340' side='right'caption='[[7nup]]' scene=''>	+	<StructureSection load='7nup' size='340' side='right'caption='[[7nup]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NUP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7nup]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NUP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nup OCA], [https://pdbe.org/7nup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nup RCSB], [https://www.ebi.ac.uk/pdbsum/7nup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nup ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=USK:(3~{S})-4-(4-hydroxyphenyl)-~{N}-oxidanyl-3-[5-[[(5-phenylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]butanamide'>USK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nup OCA], [https://pdbe.org/7nup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nup RCSB], [https://www.ebi.ac.uk/pdbsum/7nup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nup ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ERAP2_HUMAN ERAP2_HUMAN] Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.<ref>PMID:12799365</ref> <ref>PMID:15908954</ref> <ref>PMID:16286653</ref>
		+
		+	==See Also==
		+	*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Giastas P]]		[[Category: Giastas P]]
	[[Category: Mpakali A]]		[[Category: Mpakali A]]
	[[Category: Stratikos E]]		[[Category: Stratikos E]]

OCA at 09:44, 22 June 2022

OCA — Wed, 22 Jun 2022 09:44:03 GMT

←Older revision		Revision as of 09:44, 22 June 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7nup ~~is ON HOLD until Paper Publication~~	+	==Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand==
-		+	<StructureSection load='7nup' size='340' side='right'caption='[[7nup]]' scene=''>
-	~~Authors~~: ~~Mpakali~~, A., ~~Giastas~~, P., ~~Stratikos~~, E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NUP FirstGlance]. <br>
-	~~Description: Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nup OCA], [https://pdbe.org/7nup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nup RCSB], [https://www.ebi.ac.uk/pdbsum/7nup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nup ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Mpakali, A~~]]	+	__TOC__
-	[[Category: ~~Stratikos, E~~]]	+	</StructureSection>
-	[[Category: ~~Giastas, P~~]]	+	[[Category: Large Structures]]
		+	[[Category: Giastas P]]
		+	[[Category: Mpakali A]]
		+	[[Category: Stratikos E]]

OCA at 05:46, 14 April 2021

OCA — Wed, 14 Apr 2021 05:46:23 GMT

←Older revision		Revision as of 05:46, 14 April 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7nup is ON HOLD	+	The entry 7nup is ON HOLD until Paper Publication

	Authors: Mpakali, A., Giastas, P., Stratikos, E.		Authors: Mpakali, A., Giastas, P., Stratikos, E.

OCA: Protected "7nup" [edit=sysop:move=sysop]

OCA — Wed, 24 Mar 2021 05:38:35 GMT

Protected "7nup" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:38, 24 March 2021

OCA: New page: '''Unreleased structure''' The entry 7nup is ON HOLD Authors: Mpakali, A., Giastas, P., Stratikos, E. Description: Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxa...

OCA — Wed, 24 Mar 2021 05:38:33 GMT

New page: '''Unreleased structure''' The entry 7nup is ON HOLD Authors: Mpakali, A., Giastas, P., Stratikos, E. Description: Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxa...

New page

'''Unreleased structure'''

The entry 7nup is ON HOLD

Authors: Mpakali, A., Giastas, P., Stratikos, E.

Description: Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand
[[Category: Unreleased Structures]]
[[Category: Mpakali, A]]
[[Category: Stratikos, E]]
[[Category: Giastas, P]]