7nxx - Revision history

OCA at 12:41, 1 February 2024

OCA — Thu, 01 Feb 2024 12:41:25 GMT

←Older revision		Revision as of 12:41, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7nxx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NXX FirstGlance]. <br>		<table><tr><td colspan='2'>[[7nxx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NXX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.189Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nxx OCA], [https://pdbe.org/7nxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nxx RCSB], [https://www.ebi.ac.uk/pdbsum/7nxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nxx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nxx OCA], [https://pdbe.org/7nxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nxx RCSB], [https://www.ebi.ac.uk/pdbsum/7nxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nxx ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[https://omim.org/entry/105400 105400]]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>	+	[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[https://omim.org/entry/105400 105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.	+	[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
		+
		+	==See Also==
		+	*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:11, 28 September 2022

OCA — Wed, 28 Sep 2022 06:11:32 GMT

←Older revision		Revision as of 06:11, 28 September 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7nxx is ~~ON HOLD until Paper Publication~~	+	==Structure of Superoxide Dismutase 1 (SOD1) in complex with nanobody 2 (Nb2).==
-		+	<StructureSection load='7nxx' size='340' side='right'caption='[[7nxx]], [[Resolution\|resolution]] 2.19Å' scene=''>
-	~~Authors~~: ~~Gallardo~~, R., ~~Rousseau~~, F., ~~Schymkowitz, J~~., ~~Ulens, C~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7nxx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NXX FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of ~~Superoxide Dismutase~~ 1 (~~SOD1~~) in ~~complex with nanobody~~ 2 ~~(Nb2)~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nxx OCA], [https://pdbe.org/7nxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nxx RCSB], [https://www.ebi.ac.uk/pdbsum/7nxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nxx ProSAT]</span></td></tr>
-	[[Category: ~~Rousseau, F~~]]	+	</table>
-	[[Category: Gallardo, R]]	+	== Disease ==
-	[[Category: ~~Ulens, C~~]]	+	[[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[https://omim.org/entry/105400 105400]]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>
-	[[Category: Schymkowitz, J]]	+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Camelus dromedarius]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Gallardo R]]
		+	[[Category: Rousseau F]]
		+	[[Category: Schymkowitz J]]
		+	[[Category: Ulens C]]

OCA at 05:27, 22 September 2021

OCA — Wed, 22 Sep 2021 05:27:22 GMT

←Older revision		Revision as of 05:27, 22 September 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7nxx is ON HOLD	+	The entry 7nxx is ON HOLD until Paper Publication

	Authors: Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C.		Authors: Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Rousseau, F]]		[[Category: Rousseau, F]]
		+	[[Category: Gallardo, R]]
	[[Category: Ulens, C]]		[[Category: Ulens, C]]
	[[Category: Schymkowitz, J]]		[[Category: Schymkowitz, J]]
-	[[Category: Gallardo, R]]

OCA at 07:25, 8 September 2021

OCA — Wed, 08 Sep 2021 07:25:15 GMT

←Older revision		Revision as of 07:25, 8 September 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7nxx is ON HOLD ~~until sometime in the future~~	+	The entry 7nxx is ON HOLD

	Authors: Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C.		Authors: Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C.
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	Description: Structure of Superoxide Dismutase 1 (SOD1) in complex with nanobody 2 (Nb2).		Description: Structure of Superoxide Dismutase 1 (SOD1) in complex with nanobody 2 (Nb2).
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Schymkowitz, J]]
	[[Category: Rousseau, F]]		[[Category: Rousseau, F]]
	[[Category: Ulens, C]]		[[Category: Ulens, C]]
		+	[[Category: Schymkowitz, J]]
	[[Category: Gallardo, R]]		[[Category: Gallardo, R]]

OCA at 09:10, 4 August 2021

OCA — Wed, 04 Aug 2021 09:10:29 GMT

←Older revision		Revision as of 09:10, 4 August 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7nxx is ON HOLD until ~~Paper Publication~~	+	The entry 7nxx is ON HOLD until sometime in the future

	Authors: Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C.		Authors: Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C.

OCA at 06:32, 21 April 2021

OCA — Wed, 21 Apr 2021 06:32:02 GMT

←Older revision		Revision as of 06:32, 21 April 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7nxx is ON HOLD	+	The entry 7nxx is ON HOLD until Paper Publication

	Authors: Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C.		Authors: Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C.

OCA: Protected "7nxx" [edit=sysop:move=sysop]

OCA — Wed, 31 Mar 2021 09:31:59 GMT

Protected "7nxx" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:31, 31 March 2021

OCA: New page: '''Unreleased structure''' The entry 7nxx is ON HOLD Authors: Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C. Description: Structure of Superoxide Dismutase 1 (SOD1) in complex ...

OCA — Wed, 31 Mar 2021 09:31:58 GMT

New page: '''Unreleased structure''' The entry 7nxx is ON HOLD Authors: Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C. Description: Structure of Superoxide Dismutase 1 (SOD1) in complex ...

New page

'''Unreleased structure'''

The entry 7nxx is ON HOLD

Authors: Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C.

Description: Structure of Superoxide Dismutase 1 (SOD1) in complex with nanobody 2 (Nb2).
[[Category: Unreleased Structures]]
[[Category: Schymkowitz, J]]
[[Category: Rousseau, F]]
[[Category: Ulens, C]]
[[Category: Gallardo, R]]