7o0p - Revision history

OCA at 12:42, 1 February 2024

OCA — Thu, 01 Feb 2024 12:42:55 GMT

←Older revision		Revision as of 12:42, 1 February 2024
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-	====	+	==Crystal structure of the human METTL3-METTL14 complex bound to Compound 10 (ADO_AD_022)==
-	<StructureSection load='7o0p' size='340' side='right'caption='[[7o0p]]' scene=''>	+	<StructureSection load='7o0p' size='340' side='right'caption='[[7o0p]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7o0p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O0P FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o0p OCA], [https://pdbe.org/7o0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o0p RCSB], [https://www.ebi.ac.uk/pdbsum/7o0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o0p ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=UXZ:4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one'>UXZ</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o0p OCA], [https://pdbe.org/7o0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o0p RCSB], [https://www.ebi.ac.uk/pdbsum/7o0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o0p ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MTA70_HUMAN MTA70_HUMAN] N6-methyltransferase that methylates adenosine residues of some RNAs and acts as a regulator of the circadian clock, differentiation of embryonic stem cells and primary miRNA processing. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:9409616). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998).[UniProtKB:Q8C3P7]<ref>PMID:22575960</ref> <ref>PMID:24284625</ref> <ref>PMID:25719671</ref> <ref>PMID:25799998</ref> <ref>PMID:26321680</ref> <ref>PMID:26593424</ref> <ref>PMID:9409616</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Bedi RK]]
		+	[[Category: Caflisch A]]
		+	[[Category: Dolbois A]]

OCA at 09:27, 15 September 2021

OCA — Wed, 15 Sep 2021 09:27:57 GMT

←Older revision		Revision as of 09:27, 15 September 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7o0p ~~is ON HOLD until Mar 26 2023~~	+	====
-		+	<StructureSection load='7o0p' size='340' side='right'caption='[[7o0p]]' scene=''>
-	~~Authors~~: ~~Bedi, R~~.K.~~, Dolbois, A~~.~~, Caflisch, A~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description: Crystal structure of~~ the ~~human METTL3-METTL14 complex bound to Compound 10 (ADO_AD_022)~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o0p OCA], [https://pdbe.org/7o0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o0p RCSB], [https://www.ebi.ac.uk/pdbsum/7o0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o0p ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Dolbois~~, A]]	+	__TOC__
-	[[Category: ~~Caflisch, A~~]]	+	</StructureSection>
-	[[Category: ~~Bedi, R.K~~]]	+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:23, 28 April 2021

OCA — Wed, 28 Apr 2021 04:23:49 GMT

←Older revision		Revision as of 04:23, 28 April 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7o0p is ON HOLD	+	The entry 7o0p is ON HOLD until Mar 26 2023

	Authors: Bedi, R.K., Dolbois, A., Caflisch, A.		Authors: Bedi, R.K., Dolbois, A., Caflisch, A.

OCA: Protected "7o0p" [edit=sysop:move=sysop]

OCA — Wed, 07 Apr 2021 04:49:04 GMT

Protected "7o0p" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:49, 7 April 2021

OCA: New page: '''Unreleased structure''' The entry 7o0p is ON HOLD Authors: Bedi, R.K., Dolbois, A., Caflisch, A. Description: Crystal structure of the human METTL3-METTL14 complex bound to Compound...

OCA — Wed, 07 Apr 2021 04:49:03 GMT

New page: '''Unreleased structure''' The entry 7o0p is ON HOLD Authors: Bedi, R.K., Dolbois, A., Caflisch, A. Description: Crystal structure of the human METTL3-METTL14 complex bound to Compound...

New page

'''Unreleased structure'''

The entry 7o0p is ON HOLD

Authors: Bedi, R.K., Dolbois, A., Caflisch, A.

Description: Crystal structure of the human METTL3-METTL14 complex bound to Compound 10 (ADO_AD_022)
[[Category: Unreleased Structures]]
[[Category: Dolbois, A]]
[[Category: Caflisch, A]]
[[Category: Bedi, R.K]]