7oj7 - Revision history

OCA at 12:51, 1 February 2024

OCA — Thu, 01 Feb 2024 12:51:04 GMT

←Older revision		Revision as of 12:51, 1 February 2024
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	==Crystal structure of human coxsackievirus A24v in complex with a pentavalent N-acetylneuraminic acid conjugate==		==Crystal structure of human coxsackievirus A24v in complex with a pentavalent N-acetylneuraminic acid conjugate==
-	<StructureSection load='7oj7' size='340' side='right'caption='[[7oj7]]' scene=''>	+	<StructureSection load='7oj7' size='340' side='right'caption='[[7oj7]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OJ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7oj7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A24 Coxsackievirus A24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OJ7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oj7 OCA], [https://pdbe.org/7oj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oj7 RCSB], [https://www.ebi.ac.uk/pdbsum/7oj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oj7 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0H0:Carbohydrate+component+from+a+pentavalent+N-acetylneuraminic+acid+conjugate'>0H0</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oj7 OCA], [https://pdbe.org/7oj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oj7 RCSB], [https://www.ebi.ac.uk/pdbsum/7oj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oj7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/V9VEF3_9ENTO V9VEF3_9ENTO]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Coxsackievirus A24 variant (CVA24v) is the primary causative agent of the highly contagious eye infection designated acute hemorrhagic conjunctivitis (AHC). It is solely responsible for two pandemics and several recurring outbreaks of the disease over the last decades, thus affecting millions of individuals throughout the world. To date, no antiviral agents or vaccines are available for combating this disease, and treatment is mainly supportive. CVA24v utilizes Neu5Ac-containing glycans as attachment receptors facilitating entry into host cells. We have previously reported that pentavalent Neu5Ac conjugates based on a glucose-scaffold inhibit CVA24v infection of human corneal epithelial cells. In this study, we report on the design and synthesis of scaffold-replaced pentavalent Neu5Ac conjugates and their effect on CVA24v cell transduction and the use of cryogenic electron microscopy (cryo-EM) to study the binding of these multivalent conjugates to CVA24v. The results presented here provide insights into the development of Neu5Ac-based inhibitors of CVA24v and, most significantly, the first application of cryo-EM to study the binding of a multivalent ligand to a lectin.
		+
		+	Exploring the Effect of Structure-Based Scaffold Hopping on the Inhibition of Coxsackievirus A24v Transduction by Pentavalent N-Acetylneuraminic Acid Conjugates.,Johansson E, Caraballo R, Hurdiss DL, Mistry N, Andersson CD, Thompson RF, Ranson NA, Zocher G, Stehle T, Arnberg N, Elofsson M Int J Mol Sci. 2021 Aug 5;22(16). pii: ijms22168418. doi: 10.3390/ijms22168418. PMID:34445134<ref>PMID:34445134</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7oj7" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Coxsackievirus A24]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Stehle T]]		[[Category: Stehle T]]
	[[Category: Zocher G]]		[[Category: Zocher G]]

OCA at 14:47, 31 August 2022

OCA — Wed, 31 Aug 2022 14:47:06 GMT

←Older revision		Revision as of 14:47, 31 August 2022
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-	====	+	==Crystal structure of human coxsackievirus A24v in complex with a pentavalent N-acetylneuraminic acid conjugate==
	<StructureSection load='7oj7' size='340' side='right'caption='[[7oj7]]' scene=''>		<StructureSection load='7oj7' size='340' side='right'caption='[[7oj7]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OJ7 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oj7 OCA], [https://pdbe.org/7oj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oj7 RCSB], [https://www.ebi.ac.uk/pdbsum/7oj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oj7 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oj7 OCA], [https://pdbe.org/7oj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oj7 RCSB], [https://www.ebi.ac.uk/pdbsum/7oj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oj7 ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Stehle T]]
		+	[[Category: Zocher G]]

OCA at 11:44, 13 October 2021

OCA — Wed, 13 Oct 2021 11:44:18 GMT

←Older revision		Revision as of 11:44, 13 October 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7oj7 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7oj7' size='340' side='right'caption='[[7oj7]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oj7 OCA], [https://pdbe.org/7oj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oj7 RCSB], [https://www.ebi.ac.uk/pdbsum/7oj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oj7 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 07:52, 21 July 2021

OCA — Wed, 21 Jul 2021 07:52:10 GMT

←Older revision		Revision as of 07:52, 21 July 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7oj7 is ON HOLD	+	The entry 7oj7 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7oj7" [edit=sysop:move=sysop]

OCA — Wed, 26 May 2021 08:07:30 GMT

Protected "7oj7" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:07, 26 May 2021

OCA: New page: '''Unreleased structure''' The entry 7oj7 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 May 2021 08:07:29 GMT

New page: '''Unreleased structure''' The entry 7oj7 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7oj7 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]